Zinc-free, Scalable Reductive Cross-Electrophile Coupling Driven by Electrochemistry in an Undivided Cell

Synthesis of gem-Difluoroalkenes through Nickel-Promoted Electrochemical Reductive Cross-Coupling

(2022) Zhe Chang et al.   CHINESE JOURNAL OF ORGANIC CHEMISTRY

Modular terpene synthesis enabled by mild electrochemical couplings

(2022) Stephen J. Harwood et al.   SCIENCE

Synergistic Catalyst–Mediator Pairings for Electroreductive Cross-Electrophile Coupling Reactions

(2022) Jordan L. S. Zackasee et al.   ACS Catalysis

Controlling Ni redox states by dynamic ligand exchange for electroreductive Csp3–Csp2 coupling

(2022) Taylor B. Hamby et al.   SCIENCE

Homogeneous Organic Electron Donors in Nickel-Catalyzed Reductive Transformations

(2022) David J. Charboneau et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry

(2022) Chen Zhu et al.   Nature Communications

Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis

(2022) Maximilian D. Palkowitz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides

(2021) Zijian Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereoselective Preparation of C‐Aryl Glycosides via Visible‐Light‐Induced Nickel‐Catalyzed Reductive Cross‐Coupling of Glycosyl Chlorides and Aryl Bromides

(2021) Ze-Dong Mou et al.   ADVANCED SYNTHESIS & CATALYSIS

Controlled Single-Electron Transfer via Metal–Ligand Cooperativity Drives Divergent Nickel-Electrocatalyzed Radical Pathways

(2021) Anna Wuttig et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Process Chemistry Benchmark for sp2–sp3 Cross Couplings

(2021) Gregory L. Beutner et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

(2021) Tomer M. Faraggi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology

(2021) María González-Esguevillas et al.   ACS Central Science

The application of modern reactions in large-scale synthesis

(2021) Kaitlyn Lovato et al.   Nature Reviews Chemistry

Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis

(2021) Amy Y. Chan et al.   CHEMICAL REVIEWS

Tunable and Practical Homogeneous Organic Reductants for Cross-Electrophile Coupling

(2021) David J. Charboneau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Chain-Walking Cross-Electrophile Coupling of Alkyl and Aryl Halides and Olefin Hydroarylation Enabled by Electrochemical Reduction

(2020) Gadde Sathish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

General C(sp2)-C(sp3) Cross-Electrophile Coupling Reactions Enabled by Overcharge Protection of Homogeneous Electrocatalysts

(2020) Blaise L. Truesdell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multifunctional Building Blocks Compatible with Photoredox-Mediated Alkylation for DNA-Encoded Library Synthesis

(2020) Shorouk O. Badir et al.   ORGANIC LETTERS

Photoredox cross-electrophile coupling in DNA-encoded chemistry

(2020) Dominik K. Kölmel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development and Execution of an Ni(II)-Catalyzed Reductive Cross-Coupling of Substituted 2-Chloropyridine and Ethyl 3-Chloropropanoate

(2020) Sri Krishna Nimmagadda et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Electrode Materials in Modern Organic Electrochemistry

(2020) David Heard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross-Electrophile Coupling of Unactivated Alkyl Chlorides

(2020) Holt A. Sakai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Widely Applicable Dual Catalytic System for Cross-Electrophile Coupling Enabled by Mechanistic Studies

(2020) David J. Charboneau et al.   ACS Catalysis

Synergistic Dual Transition Metal Catalysis

(2020) U Bin Kim et al.   CHEMICAL REVIEWS

Recent Advances in Metal-Catalyzed, Electrochemical Coupling Reactions of sp2 Halides/Boronic Acids and sp3 Centers

(2020) Zachary J. Gale-Day   SYNTHESIS-STUTTGART

One-Pot Electrochemical Nickel-Catalyzed Decarboxylative Sp2–Sp3 Cross-Coupling

(2019) Takaoki Koyanagi et al.   ORGANIC LETTERS

Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile

(2019) Robert J. Perkins et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enantioselective Electroreductive Coupling of Alkenyl and Benzyl Halides via Nickel Catalysis

(2019) Travis J. DeLano et al.   ACS Catalysis

Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners

(2019) Atsushi Umehara et al.   CHEMISTRY LETTERS

A Metallaphotoredox Strategy for the Cross-Electrophile Coupling of α-Chloro Carbonyls with Aryl Halides

(2019) Tiffany Q. Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N,C-Disubstituted Biarylpalladacycles as Precatalysts for ppm Pd-Catalyzed Cross Couplings in Water under Mild Conditions

(2019) Ruchita R. Thakore et al.   ACS Catalysis

Nickel-Catalyzed Electrochemical Reductive Relay Cross-Coupling of Alkyl Halides to Aryl Halides

(2019) Ke-Jin Jiao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters

(2019) Eiichi Watanabe et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow

(2018) Hui Li et al.   ORGANIC LETTERS

Metallaphotoredox Difluoromethylation of Aryl Bromides

(2018) Vlad Bacauanu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoredox-Assisted Reductive Cross-Coupling: Mechanistic Insight into Catalytic Aryl–Alkyl Cross-Couplings

(2017) Avishek Paul et al.   JOURNAL OF ORGANIC CHEMISTRY

Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling

(2017) Eric C. Hansen et al.   JOURNAL OF ORGANIC CHEMISTRY

Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides

(2017) Robert J. Perkins et al.   ORGANIC LETTERS

Nickel-Catalyzed Enantioselective Cross-Coupling of N-Hydroxyphthalimide Esters with Vinyl Bromides

(2017) Naoyuki Suzuki et al.   ORGANIC LETTERS

Recent Advances in Nickel Catalysis Enabled by Stoichiometric Metallic Reducing Agents

(2017) Edward Richmond et al.   SYNTHESIS-STUTTGART

Cross-Electrophile Coupling of Vinyl Halides with Alkyl Halides

(2016) Keywan A. Johnson et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nickel-Catalyzed Cross-Electrophile Coupling with Organic Reductants in Non-Amide Solvents

(2016) Lukiana L. Anka-Lufford et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applicability of a Polymerized Ionic Liquid/Carbon Nanoparticle Composite Electrolyte to Reductive Cyclization and Dimerization Reactions

(2016) Sebastian Herold et al.   ELECTROCHIMICA ACTA

Silyl Radical Activation of Alkyl Halides in Metallaphotoredox Catalysis: A Unique Pathway for Cross-Electrophile Coupling

(2016) Patricia Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

(2016) Eric C. Hansen et al.   Nature Chemistry

Electrosynthesis Using a Recyclable Mediator–Electrolyte System Based on Ionically Tagged Phenyl Iodide and 1,1,1,3,3,3-Hexafluoroisopropanol

(2016) Timo Broese et al.   ORGANIC LETTERS

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Alkyl Bromides: Et3N as the Terminal Reductant

(2016) Zhengli Duan et al.   ORGANIC LETTERS

Toward a More Holistic Framework for Solvent Selection

(2016) Louis J. Diorazio et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Recent Developments in Negishi Cross-Coupling Reactions

(2016) Diana Haas et al.   ACS Catalysis

Nickel-Catalyzed Reductive Couplings

(2016) Xuan Wang et al.   Topics in Current Chemistry

Polymeric Ionic Liquid and Carbon Black Composite as a Reusable Supporting Electrolyte: Modification of the Electrode Surface

(2015) Seung Joon Yoo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Improved System for the Aqueous Lipshutz-Negishi Cross-Coupling of Alkyl Halides with Aryl Electrophiles

(2015) Vasudev R. Bhonde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cobalt co-catalysis for cross-electrophile coupling: diarylmethanes from benzyl mesylates and aryl halides

(2015) Laura K. G. Ackerman et al.   Chemical Science

Reductive Cross-Coupling Reactions between Two Electrophiles

(2014) Christiane E. I. Knappke et al.   CHEMISTRY-A EUROPEAN JOURNAL

4,4′,4″-Trimethyl-2,2′:6′,2″-terpyridine by Oxidative Coupling of 4-Picoline

(2014) Michael T. Robo et al.   JOURNAL OF ORGANIC CHEMISTRY

Nickel-Catalyzed Regiodivergent Opening of Epoxides with Aryl Halides: Co-Catalysis Controls Regioselectivity

(2013) Yang Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Cross-Electrophile Coupling of 2-Chloropyridines with Alkyl Bromides

(2013) Daniel Weix et al.   SYNLETT

Bimetallic Catalysis using Transition and Group 11 Metals: An Emerging Tool for CC Coupling and Other Reactions

(2012) Mónica H. Pérez-Temprano et al.   CHEMISTRY-A EUROPEAN JOURNAL

Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides

(2012) Daniel A. Everson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic catalysis: A powerful synthetic strategy for new reaction development

(2012) Anna E. Allen et al.   Chemical Science

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

(2011) Javier Magano et al.   CHEMICAL REVIEWS

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

(2011) Stephen D. Roughley et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contemporaneous Dual Catalysis by Coupling Highly Transient Nucleophilic and Electrophilic Intermediates Generated in Situ

(2011) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Some mechanistic aspects of a nickel-catalyzed electrochemical cross-coupling between aryl halides and substituted chloropyridazines

(2010) Karène Urgin et al.   ELECTROCHIMICA ACTA

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides with Alkyl Halides

(2010) Daniel A. Everson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zn-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room TemperatureWithoutPrior Formation of Organozinc Reagents

(2009) Arkady Krasovskiy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Domino Iron Catalysis: Direct Aryl-Alkyl Cross-Coupling

(2008) Waldemar Maximilian Czaplik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modern Strategies in Electroorganic Synthesis

(2008) Jun-ichi Yoshida et al.   CHEMICAL REVIEWS

One-Pot Negishi Cross-Coupling Reactions of In Situ Generated Zinc Reagents with Aryl Chlorides, Bromides, and Triflates

(2008) Shohei Sase et al.   JOURNAL OF ORGANIC CHEMISTRY