Development of intravenously administered synthetic RNA virus immunotherapy for the treatment of cancer

Small-cell lung cancer

(2021) Charles M. Rudin et al.   Nature Reviews Disease Primers

A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus

(2021) Allison August et al.   NATURE MEDICINE

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma

(2020) Lidia Franco-Luzón et al.   Oncotarget

Association Between Response to Nivolumab Treatment and Peripheral Blood Lymphocyte Subsets in Patients With Non-small Cell Lung Cancer

(2020) Selene Ottonello et al.   Frontiers in Immunology

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Oncolytic Viruses and the Immune System: The Dynamic Duo

(2020) Ana Lemos de Matos et al.   Molecular Therapy-Methods & Clinical Development

ONCR-177, an Oncolytic HSV-1 Designed to Potently Activate Systemic Antitumor Immunity

(2020) Brian B Haines et al.   Cancer Immunology Research

Liposome Encapsulation of Oncolytic Virus M1 To Reduce Immunogenicity and Immune Clearance in Vivo

(2019) Yalong Wang et al.   MOLECULAR PHARMACEUTICS

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

A phase 1 dose escalation study of the oncolytic adenovirus enadenotucirev, administered intravenously to patients with epithelial solid tumors (EVOLVE)

(2019) Jean-Pascal Machiels et al.   Journal for ImmunoTherapy of Cancer

Oncolytic viruses: overcoming translational challenges

(2019) Jordi Martinez-Quintanilla et al.   JOURNAL OF CLINICAL INVESTIGATION

Developing Picornaviruses for Cancer Therapy

(2019) McCarthy et al.   Cancers

Viral targeting of non-muscle invasive bladder cancer and priming of anti-tumour immunity following intravesical Coxsackievirus A21

(2019) Nicola E Annels et al.   CLINICAL CANCER RESEARCH

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

(2019) Nurgun Kose et al.   Science Immunology

Intratumoral Immunotherapy—Update 2019

(2019) Omid Hamid et al.   ONCOLOGIST

A Randomized Double-Blind Phase II Study of the Seneca Valley Virus (NTX-010) versus Placebo for Patients with Extensive-Stage SCLC (ES SCLC) Who Were Stable or Responding after at Least Four Cycles of Platinum-Based Chemotherapy: North Central Cancer Treatment Group (Alliance) N0923 Study

(2019) Erin L. Schenk et al.   Journal of Thoracic Oncology

Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology

(2019) Yuhua Weng et al.   Molecular Therapy-Nucleic Acids

Oncolytic Viruses for Cancer Therapy: Barriers and Recent Advances

(2019) Meijun Zheng et al.   Molecular Therapy-Oncolytics

HSV as A Platform for the Generation of Retargeted, Armed, and Reporter-Expressing Oncolytic Viruses

(2018) Laura Menotti et al.   Viruses-Basel

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts

(2018) Benjamin J. Drapkin et al.   Cancer Discovery

Antibody-Neutralized Reovirus Is Effective in Oncolytic Virotherapy

(2018) Robert A. Berkeley et al.   Cancer Immunology Research

Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1

(2018) Lin Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome wide analysis of the evolution of Senecavirus A from swine clinical material and assembly yard environmental samples

(2017) Wanhong Xu et al.   PLoS One

Recommendations of the Oligonucleotide Safety Working Group's Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based Therapeutics

(2017) Jennifer L. Marlowe et al.   Nucleic Acid Therapeutics

Liposome-encapsulated plasmid DNA of telomerase-specific oncolytic adenovirus with stealth effect on the immune system

(2017) Katsuyuki Aoyama et al.   Scientific Reports

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

Polymeric oncolytic adenovirus for cancer gene therapy

(2015) Joung-Woo Choi et al.   JOURNAL OF CONTROLLED RELEASE

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma

(2015) Peng-Peng Zhu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

PEGylation of Vesicular Stomatitis Virus Extends Virus Persistence in Blood Circulation of Passively Immunized Mice

(2013) M. Z. Tesfay et al.   JOURNAL OF VIROLOGY

Intravenous administration of Reolysin®, a live replication competent RNA virus is safe in patients with advanced solid tumors

(2009) Radharani Gollamudi et al.   INVESTIGATIONAL NEW DRUGS

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

(2009) Marc T Abrams et al.   MOLECULAR THERAPY

Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus

(2008) L. M. Hales et al.   JOURNAL OF GENERAL VIROLOGY