Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB

Potential Networks Regulated by MSCs in Acute-On-Chronic Liver Failure: Exosomal miRNAs and Intracellular Target Genes

(2021) Jing Zhang et al.   Frontiers in Genetics

FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis

(2020) Katrin Panzitt et al.   JOURNAL OF HEPATOLOGY

Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities

(2020) Amy Y. Clark et al.   Nature Communications

MicroRNA profiles in serum samples from Acute-On-Chronic Liver Failure patients and miR-25-3p as a potential biomarker for survival prediction

(2020) Júlia Cisilotto et al.   Scientific Reports

Reduced Let-7f in Bone Marrow-Derived Mesenchymal Stem Cells Triggers Treg/Th17 Imbalance in Patients With Systemic Lupus Erythematosus

(2020) Linyu Geng et al.   Frontiers in Immunology

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

(2020) Chuanbin Yang et al.   Redox Biology

MSCs ameliorate hepatocellular apoptosis mediated by PINK1-dependent mitophagy in liver ischemia/reperfusion injury through AMPKα activation

(2020) Jun Zheng et al.   Cell Death & Disease

Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR

(2019) Bin Ye et al.   Autophagy

Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders

(2019) Milad Riazifar et al.   ACS Nano

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update

(2019) Shiv Kumar Sarin et al.   Hepatology International

Mitofusin2, as a Protective Target in the Liver, Controls the Balance of Apoptosis and Autophagy in Acute-on-Chronic Liver Failure

(2019) Ran Xue et al.   Frontiers in Pharmacology

Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

(2019) Yoda Yaghoubi et al.   LIFE SCIENCES

Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b

(2018) Changchen Xiao et al.   CIRCULATION RESEARCH

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

(2018) Yufang Shi et al.   Nature Reviews Nephrology

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

(2018) Cynthia L. Hsu et al.   Nature Communications

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Identification and Modulation of Microenvironment is Crucial for Effective MSC Therapy in Acute Lung Injury

(2018) Diana Islam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Activation of autophagy, observed in liver tissues from patients with Wilson disease and from Atp7b-deficient animals, protects hepatocytes from copper-induced apoptosis

(2018) Elena V. Polishchuk et al.   GASTROENTEROLOGY

A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD

(2018) Peilong Lai et al.   Journal of Hematology & Oncology

Acute-on-chronic liver failure: an update

(2017) Ruben Hernaez et al.   GUT

Allogeneic bone marrow-derived mesenchymal stromal cells for hepatitis B virus-related acute-on-chronic liver failure: A randomized controlled trial

(2017) Bing-liang Lin et al.   HEPATOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α

(2016) F Ren et al.   Cell Death & Disease

FoxO1-mediated autophagy is required for NK cell development and innate immunity

(2016) Shuo Wang et al.   Nature Communications

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Acute-on-chronic liver failure

(2015) William Bernal et al.   LANCET

Annexin A2 promotes phagophore assembly by enhancing Atg16L+ vesicle biogenesis and homotypic fusion

(2015) Kateryna Morozova et al.   Nature Communications

Aging Mesenchymal Stem Cells Fail to Protect Because of Impaired Migration and Antiinflammatory Response

(2014) Martha L. Bustos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Let-7 Coordinately Suppresses Components of the Amino Acid Sensing Pathway to Repress mTORC1 and Induce Autophagy

(2014) Amy N. Dubinsky et al.   Cell Metabolism

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Entecavir improves the outcome of acute-on-chronic liver failure due to the acute exacerbation of chronic hepatitis B

(2013) Bingliang Lin et al.   Hepatology International

Human Placenta-Derived Mesenchymal Stem Cells Promote Hepatic Regeneration in CCl4-Injured Rat Liver Model via Increased Autophagic Mechanism

(2013) Jieun Jung et al.   STEM CELLS

Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

(2012) Sudhir H. Ranganath et al.   Cell Stem Cell

Systematic review and meta-analysis of survival following extracorporeal liver support

(2011) B. M. Stutchfield et al.   BRITISH JOURNAL OF SURGERY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

(2010) Satoshi Shimizu et al.   JOURNAL OF HEPATOLOGY

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT