Article
Chemistry, Multidisciplinary
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Summary: Multidrug resistance (MDR) reduces the efficacy of chemotherapy by inducing drug efflux pumps and altering the tumor microenvironment (TME) composition, limiting drug delivery. Multidrug-resistant tumors displayed a more mesenchymal phenotype, increased collagen production, enriched TME, and enhanced vascular perfusion. Drug carriers accumulated more efficiently in resistant tumors but had a limited ability to penetrate the interstitium. Microenvironmental drug resistance affected liposomal doxorubicin performance more than free doxorubicin.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Engineering, Biomedical
Ju Huang, Xiaojing Leng, Tao Jiang, Lihong Xu, Jun Zheng, Mingxiao Fang, Jingxue Wang, Zhigang Wang, Liang Zhang
Summary: Immunotherapy has great potential for treating tumors, but antigen exposure and immuno-suppressive tumor microenvironment (TME) caused by hypoxia limit its effectiveness. This study developed an oxygen-carrying nanoplatform to reprogram the immunosuppressive TME and enhance photothermal-immunotherapy. The nanoplatform showed efficient oxygen release behavior and excellent hyperthermia performance, attenuating tumor hypoxia and exposing tumor-associated antigens. The combination of photothermal therapy with anti-PD-1 immunotherapy induced a strong antitumor immune response and suppressed tumor growth.
MATERIALS TODAY BIO
(2023)
Review
Pharmacology & Pharmacy
Qiu-Ping Liu, Jia-Yi Lin, Pei An, Yu-Ying Chen, Xin Luan, Hong Zhang
Summary: Abnormal expression of lncRNAs in the tumor microenvironment typically leads to increased proliferation, migration, and drug resistance of tumor cells, however, regulating the expression of lncRNAs in TME can significantly inhibit tumor progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xinyuan Shen, Chaojie Zhu, Qing Wu, Jiaqi Shi, Wei Wu, Xiao Zhao, Jie Sun, Hongjun Li, Zhen Gu
Summary: This review explores the rational design of nanomodulators to target tumor-resident immunosuppressive cells and provides an overview of the basic functions and therapeutic strategies for each cell type. Challenges and future research perspectives are also discussed.
Review
Pharmacology & Pharmacy
Ting Jiang, Xisha Chen, Xingcong Ren, Jin-Ming Yang, Yan Cheng
Summary: This article discusses the important roles of autophagy in tumor cells, immune cells, and stromal cells in the context of tumor immunity, as well as the potential of combining autophagy-based therapy with immunotherapy as novel therapeutic approaches against cancer.
DRUG RESISTANCE UPDATES
(2021)
Article
Chemistry, Multidisciplinary
Xin Liu, Ningbing Ye, Chen Xiao, Xiaoxian Wang, Shiyou Li, Yihan Deng, Xiaoquan Yang, Zifu Li, Xiangliang Yang
Summary: This study demonstrated for the first time the successful combination of hyperbaric oxygen (HBO) therapy with commercialized nanomedicines in eliminating cancer stem-like cells (CSCs) in solid tumors, showing efficient anticancer effects in treating tumors such as triple negative breast cancer and pancreatic ductal adenocarcinoma.
Article
Immunology
Shuheng Bai, Ling Chen, Yanli Yan, Rong Li, Yun Zhou, Xuan Wang, Haojing Kang, Zhaode Feng, Guangzu Li, Shuling Zhou, Emmanuel Kwateng Drokow, Juan Ren
Summary: Hypoxia has significant impact on the prognosis and clinical response to ICI therapy in COAD by inducing different biological processes and immune characteristics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yejiao Ruan, Lingyun He, Jiamin Chen, Jinfeng Wang, Shujing Zhao, Xiaoling Guo, Yao Xie, Zhenzhai Cai, Xian Shen, Chao Li
Summary: There is still a lack of convenient ways to simulate the in vivo hypoxic tumor microenvironment (TME) under normoxia in vitro. In this study, a three-dimensional culture system with a core-shell structure (3d-ACS) was established to simulate the hypoxic TME. The gastric cancer cells formed organoid-like structures in the 3d-ACS and showed more aggressive growth and decreased drug responses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Wenlu Yan, Tianqun Lang, Runqi Zhu, Xiao Zhu, Yu Li, Ting Wu, Qi Yin, Yaping Li
Summary: This review summarizes the latest research progress on improving cancer therapy using anti-hypoxia nanosized drug delivery systems (NDDSs), including mechanisms such as increasing oxygen supply, reducing oxygen consumption, and inhibiting hypoxia-related signaling pathways.
Review
Immunology
Stefan Forster, Ramin Radpour, Adrian F. Ochsenbein
Summary: Multiple myeloma (MM) is a hematologic malignancy characterized by the proliferation of clonal plasma cells in the bone marrow. The interaction between myeloma cells and the tumor microenvironment (TME) plays a crucial role in MM progression. Understanding the molecular mechanisms that drive MM and therapy resistance is essential for developing successful therapies and preventing MM recurrence. This review summarizes key mechanisms and emerging therapies in MM, including autocrine signaling, interactions with TME, and drug-resistance mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
H. Lee, D. K. Dey, K. Kim, S. Kim, E. Kim, S. C. Kang, V. K. Bajpai, Y. S. Huh
Summary: Hypoxia-responsive nanoparticles were developed to selectively release anticancer drugs under hypoxic conditions, enhancing the antitumor activity. This strategy demonstrates effective control of drug distribution within a hypoxic tumor microenvironment, improving treatment outcomes.
MATERIALS TODAY ADVANCES
(2022)
Review
Chemistry, Multidisciplinary
Shaojun Peng, Fengfeng Xiao, Meiwan Chen, Huile Gao
Summary: Cancer immunotherapy has made great progress in the past decades, but challenges such as low patient response rates and potential immune-related adverse events persist. Tumor-microenvironment (TME)-responsive nanomedicine has shown promise in amplifying immune responses in a specific and localized manner within tumor tissue, leading to increased patient response rates and reduced immune-related side effects.
Review
Oncology
R. F. Zaarour, M. Ribeiro, B. Azzarone, S. Kapoor, S. Chouaib
Summary: The interaction between tumor hypoxic stress and its role in stemness acquisition and maintenance is crucial for cancer treatment approaches. Hypoxia is associated with tumor aggressiveness and impacts susceptibility and resistance to different treatments. Hypoxia influences tumor heterogeneity and plasticity, but its significance in cancer stem cell development is still poorly understood. Evidence shows that cancer stem cells in a hypoxic tumor microenvironment have a role in cancer progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Geraldine Luis, Adrien Godfroid, Shin Nishiumi, Jonathan Cimino, Silvia Blacher, Erik Maquoi, Coline Wery, Alice Collignon, Remi Longuespee, Laetitia Montero-Ruiz, Isabelle Dassoul, Naima Maloujahmoum, Charles Pottier, Gabriel Mazzucchelli, Edwin Depauw, Akeila Bellahcene, Masaru Yoshida, Agnes Noel, Nor Eddine Sounni
Summary: The study revealed that SCD1 and FABP4 play essential roles in tumor recurrence by enhancing antioxidant and anti-ferroptotic resources. Inhibiting lipid transport and targeting SCD1 can effectively reduce tumor regrowth.
Review
Biochemistry & Molecular Biology
Mariaconcetta Cariello, Angela Squilla, Martina Piacente, Giorgia Venutolo, Alessio Fasano
Summary: Extracellular vesicles (EVs), specifically exosomes, play a crucial role in the communication and information exchange between tumor cells and the tumor microenvironment (TME), as well as in the development of anti-cancer drug resistance (DR). The release of exosomes by cancer cells is triggered by the alteration of oxygen levels due to increased cancer cell proliferation. This review focuses on discussing the role and mechanism of exosomal miRNA in DR in hematological tumors, namely leukemia, lymphoma, and multiple myeloma. In conclusion, understanding the cargo of exosomes highlights their potential as targeted drug delivery vehicles, allowing for personalized therapy.