Arsenic Induces GSK3β-Dependent p-Tau, Neuronal Apoptosis, and Cognitive Impairment via an Interdependent Hippocampal ERα and IL-1/IL-1R1 Mechanism in Female Rats

Arsenic Induces Differential Neurotoxicity in Male, Female, and E2-Deficient Females: Comparative Effects on Hippocampal Neurons and Cognition in Adult Rats

(2022) Rukmani Pandey et al.   MOLECULAR NEUROBIOLOGY

Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and targeted treatment of autoimmune and inflammatory diseases

(2021) Giulio Cavalli et al.   AUTOIMMUNITY REVIEWS

Role of metallic pollutants in neurodegeneration: effects of aluminum, lead, mercury, and arsenic in mediating brain impairment events and autism spectrum disorder

(2021) Ishnoor Kaur et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2

(2021) Churaibhon Wisessaowapak et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Resveratrol attenuates arsenic-induced cognitive deficits via modulation of Estrogen-NMDAR-BDNF signalling pathway in female mouse hippocampus

(2021) Kamakshi Mehta et al.   PSYCHOPHARMACOLOGY

Exposure to Environmental Arsenic and Emerging Risk of Alzheimer’s Disease: Perspective Mechanisms, Management Strategy, and Future Directions

(2021) Md. Ataur Rahman et al.   Toxics

Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats

(2021) Heba M. Mansour et al.   NEUROCHEMISTRY INTERNATIONAL

Neurotoxic Mechanism of Arsenic: Synergistic Effect of Mitochondrial Instability, Oxidative Stress, and Hormonal-Neurotransmitter Impairment

(2020) Nandita Medda et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense

(2020) Ning Bai et al.   Journal of Neuroinflammation

Trigeminal neuralgia causes neurodegeneration in rats associated with upregulation of the CD95/CD95L pathway

(2020) Lu Wang et al.   Molecular Pain

Glycogen synthase kinase-3 signaling in Alzheimer's disease

(2020) Elisabetta Lauretti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of environmental toxicants on neuronal functions

(2020) Supriya Sharma et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Learning and memory deficits and Alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR

(2019) Jing Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Estradiol and selective estrogen receptor agonists differentially affect brain monoamines and amino acids levels in transitional and surgical menopausal rat models

(2019) Tao Long et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Estrogen deficiency induces memory loss via altered hippocampal HB-EGF and autophagy

(2019) Rukmani Pandey et al.   JOURNAL OF ENDOCRINOLOGY

Rutin attenuates cerebral ischemia/reperfusion injury in ovariectomized rats via estrogen receptor-mediated BDNF-TrkB and NGF-TrkA signaling

(2018) Hong Liu et al.   Biochemistry and Cell Biology

Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer’s Disease Model

(2018) Sandra Aurora Niño et al.   ACS Chemical Neuroscience

Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K/Akt/mTOR signaling pathway: involvement of blood–brain barrier’s tight junction proteins

(2018) Ram Kumar Manthari et al.   ARCHIVES OF TOXICOLOGY

Rosiglitazone up-regulates glial fibrillary acidic protein via HB-EGF secreted from astrocytes and neurons through PPARγ pathway and reduces apoptosis in high-fat diet-fed mice

(2018) Rajesh Kushwaha et al.   JOURNAL OF NEUROCHEMISTRY

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Amyloid-Beta and Phosphorylated Tau Accumulations Cause Abnormalities at Synapses of Alzheimer’s disease Neurons

(2017) Ravi Rajmohan et al.   JOURNAL OF ALZHEIMERS DISEASE

Apoptosis Induced by the UV Filter Benzophenone-3 in Mouse Neuronal Cells Is Mediated via Attenuation of Erα/Pparγ and Stimulation of Erβ/Gpr30 Signaling

(2017) A. Wnuk et al.   MOLECULAR NEUROBIOLOGY

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

From the Cover: Arsenic Induces Hippocampal Neuronal Apoptosis and Cognitive Impairments via an Up-Regulated BMP2/Smad-Dependent Reduced BDNF/TrkB Signaling in Rats

(2017) Rukmani Pandey et al.   TOXICOLOGICAL SCIENCES

Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus

(2017) Hongna Sun et al.   Frontiers in Molecular Neuroscience

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice

(2015) Liangru Zhu et al.   ENDOCRINOLOGY

Contribution of estrogen receptor subtypes, ERα, ERβ, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice

(2015) Ashok Kumar et al.   HIPPOCAMPUS

Cypermethrin Stimulates GSK3β-Dependent Aβ and p-tau Proteins and Cognitive Loss in Young Rats: Reduced HB-EGF Signaling and Downstream Neuroinflammation as Critical Regulators

(2015) Shailendra Kumar Maurya et al.   MOLECULAR NEUROBIOLOGY

Brain-borne IL-1 adjusts glucoregulation and provides fuel support to astrocytes and neurons in an autocrine/paracrine manner

(2015) A del Rey et al.   MOLECULAR PSYCHIATRY

Inhibition of hippocampal estrogen synthesis by reactive microglia leads to down-regulation of synaptic protein expression

(2015) Siriporn Chamniansawat et al.   NEUROTOXICOLOGY

Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression

(2015) Chia-Yu Chang et al.   Biomed Research International

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Lentivirus-mediated estrogen receptor α overexpression in the central nervous system ameliorates experimental autoimmune encephalomyelitis in mice

(2013) XIAO HU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Targeting Estrogen Receptors for the Treatment of Alzheimer’s Disease

(2013) Jung Hoon Lee et al.   MOLECULAR NEUROBIOLOGY

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Developmental Exposure to As, Cd, and Pb Mixture Diminishes Skeletal Growth and Causes Osteopenia at Maturity via Osteoblast and Chondrocyte Malfunctioning in Female Rats

(2013) Sabiya Abbas et al.   TOXICOLOGICAL SCIENCES

Exposure to As, Cd and Pb-mixture impairs myelin and axon development in rat brain, optic nerve and retina

(2013) Nagendra Kumar Rai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A Lack of Ovarian Function Increases Neuroinflammation in Aged Mice

(2012) Valeria Benedusi et al.   ENDOCRINOLOGY

Oestrogen receptor α agonist improved long-term ovariectomy-induced spatial cognition deficit in young rats

(2012) Na Qu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Tau protein is involved in morphological plasticity in hippocampal neurons in response to BDNF

(2012) Qian Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Purple sweet potato color attenuates domoic acid-induced cognitive deficits by promoting estrogen receptor-α-mediated mitochondrial biogenesis signaling in mice

(2011) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging

(2011) Thomas C. Foster   HIPPOCAMPUS

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

The Arsenic Exposure Hypothesis for Alzheimer Disease

(2010) Gordon Gong et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Estrogen receptor agonists and estrogen attenuate TNF- -induced apoptosis in VSC4.1 motoneurons

(2010) A. Das et al.   JOURNAL OF ENDOCRINOLOGY

Characterization of Developmental Neurotoxicity of As, Cd, and Pb Mixture: Synergistic Action of Metal Mixture in Glial and Neuronal Functions

(2010) Asit Rai et al.   TOXICOLOGICAL SCIENCES

Connection between inflammatory processes and transmittor function—Modulatory effects of interleukin-1

(2009) Stefan Spulber et al.   PROGRESS IN NEUROBIOLOGY

Arsenic-induced neurotoxicity in relation to toxicokinetics: Effects on sciatic nerve proteins

(2008) A. Vahidnia et al.   CHEMICO-BIOLOGICAL INTERACTIONS