Suppression of NADPH oxidase 4 inhibits PM2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway

Transforming growth factor-β in myocardial disease

(2022) Nikolaos G. Frangogiannis   Nature Reviews Cardiology

CXCL4 drives fibrosis by promoting several key cellular and molecular processes

(2022) Alsya J. Affandi et al.   Cell Reports

PM2.5 increases mouse blood pressure by activating toll-like receptor 3

(2022) Jinna Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Fine particulate matter air pollution and subclinical cardiovascular outcomes: A longitudinal study in 15 Chinese cities

(2022) Jialu Hu et al.   ENVIRONMENT INTERNATIONAL

Reactive Oxygen Species Induced Pathways in Heart Failure Pathogenesis and Potential Therapeutic Strategies

(2022) Aušra Mongirdienė et al.   Biomedicines

Ceramide metabolism mediates the impaired glucose homeostasis following short-term black carbon exposure: A targeted lipidomic analysis

(2022) Yifan Xu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Comparative studies on regional variations in PM2.5 in the induction of myocardial hypertrophy in mice

(2021) Qisong Xing et al.   SCIENCE OF THE TOTAL ENVIRONMENT

N-Acetylcysteine Slows Down Cardiac Pathological Remodeling by Inhibiting Cardiac Fibroblast Proliferation and Collagen Synthesis

(2021) Jin Zhou et al.   DISEASE MARKERS

Cardiac Remodeling and Repair: Recent Approaches, Advancements, and Future Perspective

(2021) Perwez Alam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spatial Distribution of PM 2.5 ‐Related Premature Mortality in China

(2021) Sheng Zheng et al.   GeoHealth

NADPH Oxidase Inhibition in Fibrotic Pathologies

(2020) Karen Bernard et al.   ANTIOXIDANTS & REDOX SIGNALING

Combined exposure of fine particulate matter and high-fat diet aggravate the cardiac fibrosis in C57BL/6J mice

(2020) Jinjin Jiang et al.   JOURNAL OF HAZARDOUS MATERIALS

Long-Term Exposure to Fine Particulate Matter and Cardiovascular Disease in China

(2020) Fengchao Liang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Regulators of Cardiac Fibroblast Cell State

(2020) Ross Bretherton et al.   MATRIX BIOLOGY

Association Between Cardiovascular Disease and Long-term Exposure to Air Pollution With the Risk of Dementia

(2020) Giulia Grande et al.   JAMA Neurology

HA-Modified R8-Based Bola-Amphiphile Nanocomplexes for Effective Improvement of siRNA Delivery Efficiency

(2020) Nan Jia et al.   ACS Biomaterials-Science & Engineering

Melatonin ameliorates PM 2.5 ‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

(2020) Jinjin Jiang et al.   JOURNAL OF PINEAL RESEARCH

ANO1 regulates cardiac fibrosis via ATI-mediated MAPK pathway

(2020) Xiangqin Tian et al.   CELL CALCIUM

Right Ventricular Fibrosis

(2019) Stine Andersen et al.   CIRCULATION

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice

(2019) Kah Yong Goh et al.   Redox Biology

HIMF (Hypoxia-Induced Mitogenic Factor)-IL (Interleukin)-6 Signaling Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Hypertrophy and Fibrosis

(2019) Santosh Kumar et al.   HYPERTENSION

Protocatechuic acid attenuates angiotensin II‐induced cardiac fibrosis in cardiac fibroblasts through inhibiting the NOX4/ROS/p38 signaling pathway

(2019) Hui Song et al.   PHYTOTHERAPY RESEARCH

Cardiovascular effects of airborne particulate matter: A review of rodent model studies

(2019) Mostafa Hadei et al.   CHEMOSPHERE

The Acute Effects of Age and Particulate Matter Exposure on Heart Rate and Heart Rate Variability in Mice

(2018) Blake A. Bennett et al.   Cardiovascular Toxicology

Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice

(2018) Guohua Qin et al.   Particle and Fibre Toxicology

Long-Term Exposure to Ultrafine Particles and Incidence of Cardiovascular and Cerebrovascular Disease in a Prospective Study of a Dutch Cohort

(2018) George S. Downward et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Mass spectrometry-based metabolomics reveals the mechanism of ambient fine particulate matter and its components on energy metabolic reprogramming in BEAS-2B cells

(2018) Yuanyuan Song et al.   SCIENCE OF THE TOTAL ENVIRONMENT

PM2.5-induced alteration of DNA methylation and RNA-transcription are associated with inflammatory response and lung injury

(2018) Yanfeng Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Identification of mRNA-miRNA crosstalk in human endothelial cells after exposure of PM2.5 through integrative transcriptome analysis

(2018) Yan Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p/ transforming growth factor β type II receptor axis

(2018) Meiqiong Wu et al.   CHEMOSPHERE

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration

(2017) Tingting Ku et al.   Particle and Fibre Toxicology

Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice

(2017) Koustav Ganguly et al.   Particle and Fibre Toxicology

MicroRNA-29a suppresses cardiac fibroblasts proliferation via targeting VEGF-A/MAPK signal pathway

(2016) Hui Tao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sulfur Dioxide Contributes to the Cardiac and Mitochondrial Dysfunction in Rats

(2016) Guohua Qin et al.   TOXICOLOGICAL SCIENCES

Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation

(2016) Qi Zhang et al.   Scientific Reports

N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition

(2015) Cong Liu et al.   BMC Cardiovascular Disorders

A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway

(2015) Qian Yin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Function and Therapeutic Potential of Noncoding RNAs in Cardiac Fibrosis

(2015) Esther E. Creemers et al.   CIRCULATION RESEARCH

Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β

(2015) Sonsoles Piera-Velazquez et al.   Arthritis & Rheumatology

Danshensu Inhibits β-Adrenergic Receptors-Mediated Cardiac Fibrosis by ROS/p38 MAPK Axis

(2014) Haiyan Lu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tumor Necrosis Factor-α-Induced Colitis Increases NADPH Oxidase 1 Expression, Oxidative Stress, and Neutrophil Recruitment in the Colon: Preventive Effect of Apocynin

(2014) Souad Mouzaoui et al.   MEDIATORS OF INFLAMMATION

NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses

(2014) Fan Jiang et al.   Redox Biology

TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves

(2013) Michael A. Hagler et al.   CARDIOVASCULAR RESEARCH

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Mediates the Differential Responsiveness of Atrial Versus Ventricular Fibroblasts to Transforming Growth Factor-β

(2013) Yung-Hsin Yeh et al.   Circulation-Arrhythmia and Electrophysiology

Cardiovascular Remodeling in Response to Long-Term Exposure to Fine Particulate Matter Air Pollution

(2012) Loren E. Wold et al.   Circulation-Heart Failure

A TRPC6-Dependent Pathway for Myofibroblast Transdifferentiation and Wound Healing In Vivo

(2012) Jennifer Davis et al.   DEVELOPMENTAL CELL

Exosome-mediated delivery of siRNA in vitro and in vivo

(2012) Samir El-Andaloussi et al.   Nature Protocols

Particulate Matter Induces Translocation of IL-6 from the Lung to the Systemic Circulation

(2010) Takashi Kido et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

NADPH Oxidase and Cardiac Failure

(2010) Junya Kuroda et al.   Journal of Cardiovascular Translational Research

Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

(2009) Florian H. Seeger et al.   BASIC RESEARCH IN CARDIOLOGY

Induction of IL-6 and inhibition of IL-8 secretion in the human airway cell line Calu-3 by urban particulate matter collected with a modified method of PM sampling

(2009) Ernesto Alfaro-Moreno et al.   ENVIRONMENTAL RESEARCH

Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter

(2009) Joanna Shoenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Renal, vascular and cardiac fibrosis in rats exposed to passive smoking and industrial dust fibre amosite

(2008) Peter Boor et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE