The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms

Control of coronary vascular resistance by eicosanoids via a novel GPCR

(2022) Nabil J. Alkayed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections

(2021) Cindy B. McReynolds et al.   Frontiers in Physiology

Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss

(2021) Shinichiro Koike et al.   FREE RADICAL BIOLOGY AND MEDICINE

New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation

(2021) Nalin Singh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer’s Disease

(2020) Christian Griñán-Ferré et al.   Neurotherapeutics

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

(2020) Kelsey M. Pinckard et al.   CIRCULATION

Cytochrome P450 Metabolism of Polyunsaturated Fatty Acids and Neurodegeneration

(2020) Morteza Sarparast et al.   Nutrients

Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection

(2019) Antonia Alexandra Evripioti et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2

(2019) Amy A. Rand et al.   JOURNAL OF LIPID RESEARCH

Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases

(2019) Jogen Atone et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

(2018) Kristin I. Stanford et al.   Cell Metabolism

GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells

(2018) Sang-Kyu Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson’s disease

(2018) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132

(2018) Jamie L. Lahvic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t -TUCB in horses with experimentally induced radiocarpal synovitis

(2017) A. G. P. Guedes et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling

(2017) Bing-Qing Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid

(2017) Xuehong Liu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Detection of omega-3 oxylipins in human plasma and response to treatment with omega-3 acid ethyl esters

(2017) Gregory C. Shearer et al.   JOURNAL OF LIPID RESEARCH

Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis

(2016) A. Guedes et al.   EQUINE VETERINARY JOURNAL

Epoxy fatty acids mediate analgesia in murine diabetic neuropathy

(2016) K. Wagner et al.   EUROPEAN JOURNAL OF PAIN

Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress

(2016) Qian Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

(2016) Verena Katharina Raker et al.   Frontiers in Immunology

Protein kinase inhibitor β enhances the constitutive activity of G-protein-coupled zinc receptor GPR39

(2014) Zsuzsa Kovacs et al.   BIOCHEMICAL JOURNAL

Müller glia cells regulate Notch signaling and retinal angiogenesis via the generation of 19,20-dihydroxydocosapentaenoic acid

(2014) Jiong Hu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Universal Real-Time PCR-Based Assay for Lentiviral Titration

(2014) Wojciech Barczak et al.   MOLECULAR BIOTECHNOLOGY

Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis

(2014) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue

(2013) Ahmed Bettaieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts

(2013) Garrett J. Gross et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis

(2013) G. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

(2012) Christophe Morisseau et al.   Annual Review of Pharmacology and Toxicology

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2

(2012) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs

(2011) Marijn PA Sanders et al.   BMC BIOINFORMATICS

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

(2011) Brady K Atwood et al.   BMC GENOMICS

Regulation of forskolin-induced cAMP production by cytochrome P450 epoxygenase metabolites of arachidonic acid in HEK293 cells

(2011) Mohamed Abukhashim et al.   CELL BIOLOGY AND TOXICOLOGY

Development of a semi-automated LC/MS/MS method for the simultaneous quantitation of 14,15-epoxyeicosatrienoic acid, 14,15-dihydroxyeicosatrienoic acid, leukotoxin and leukotoxin diol in human plasma as biomarkers of soluble epoxide hydrolase activity in vivo

(2011) Penny Zhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Soluble Epoxide Hydrolase Deficiency Attenuates Neointima Formation in the Femoral Cuff Model of Hyperlipidemic Mice

(2010) Marc Revermann et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids

(2010) Christophe Morisseau et al.   JOURNAL OF LIPID RESEARCH

14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP2 receptors in rat mesenteric artery

(2010) Cui Yang et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Novel Genetically Encoded Biosensors Using Firefly Luciferase

(2008) Frank Fan et al.   ACS Chemical Biology