Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogenBurkholderia pseudomallei

Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors

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A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity

(2016) Jung H. Suh et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival ofBurkholderia pseudomallei

(2016) Rafael Custódio et al.   MOLECULAR MICROBIOLOGY

Legionella pneumophilaS1P-lyase targets host sphingolipid metabolism and restrains autophagy

(2016) Monica Rolando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orally Active 7-Substituted (4-Benzylphthalazin-1-yl)-2-methylpiperazin-1-yl]nicotinonitriles as Active-Site Inhibitors of Sphingosine 1-Phosphate Lyase for the Treatment of Multiple Sclerosis

(2014) Sven Weiler et al.   JOURNAL OF MEDICINAL CHEMISTRY

A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase

(2014) Markus A. Keller et al.   Nature Communications

The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin

(2013) John M. Wadsworth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

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(2013) María A Martínez et al.   Revista Chilena de Infectologia

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

(2013) Laura C. Wieland Brown et al.   PLOS BIOLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement

(2012) Anja Lüth et al.   ANALYTICA CHIMICA ACTA

Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry

(2012) Ester Reina et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Mechanisms of antibiotic resistance inBurkholderia pseudomallei: implications for treatment of melioidosis

(2012) Herbert P Schweizer   Future Microbiology

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis

(2011) Matthew E Wand et al.   BMC MICROBIOLOGY

Extracellular and intracellular sphingosine-1-phosphate in cancer

(2011) Jessie W. Yester et al.   CANCER AND METASTASIS REVIEWS

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Unusual Outer Membrane Lipid Composition of the Gram-negative, Lipopolysaccharide-lacking MyxobacteriumSorangium cellulosumSo ce56

(2011) Matthias Keck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization–liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal

(2010) Evgeny V. Berdyshev et al.   ANALYTICAL BIOCHEMISTRY

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

An improved two-step synthetic route to primary allylic alcohols from aldehydes

(2010) Zheng Liu et al.   NEW JOURNAL OF CHEMISTRY

Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

(2010) D. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism

(2010) Florence Bourquin et al.   STRUCTURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate

(2009) Padmavathi Bandhuvula et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol

(2009) Huanting Liu et al.   BMC BIOTECHNOLOGY

ALegionellaeffector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria

(2009) Elena Degtyar et al.   CELLULAR MICROBIOLOGY

Synthesis of a Fluorogenic Analogue of Sphingosine-1-Phosphate and Its Use to Determine Sphingosine-1-Phosphate Lyase Activity

(2009) Carmen Bedia et al.   CHEMBIOCHEM

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

The Burkholderia Genome Database: facilitating flexible queries and comparative analyses

(2008) G. L. Winsor et al.   BIOINFORMATICS

Burkholderia thailandensis as a Model System for the Study of the Virulence-Associated Type III Secretion System of Burkholderia pseudomallei

(2008) A. Haraga et al.   INFECTION AND IMMUNITY

CHAINSAW: a program for mutating pdb files used as templates in molecular replacement

(2008) Norman Stein   JOURNAL OF APPLIED CRYSTALLOGRAPHY