E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis

Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes

(2015) Xin Tong et al.   PLoS One

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy

(2015) Carolina Simioni et al.   Oncotarget

Ring finger protein20 regulates hepatic lipid metabolism through protein kinase A-dependent sterol regulatory element binding protein1c degradation

(2014) Jae Ho Lee et al.   HEPATOLOGY

Liver Clock Protein BMAL1 Promotesde NovoLipogenesis through Insulin-mTORC2-AKT Signaling

(2014) Deqiang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Nfil3Is a Glucocorticoid-Regulated Gene Required for Glucocorticoid-Induced Apoptosis in Male Murine T Cells

(2013) Kirstyn T. Carey et al.   ENDOCRINOLOGY

Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice

(2013) Heidi L. Kenerson et al.   GASTROENTEROLOGY

Recruitment of Histone Methyltransferase G9a Mediates Transcriptional Repression ofFgf21Gene by E4BP4 Protein

(2013) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 and energy metabolism

(2012) X. Li   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

USP2a Protein Deubiquitinates and Stabilizes the Circadian Protein CRY1 in Response to Inflammatory Signals

(2012) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

(2011) Jessica L. Yecies et al.   Cell Metabolism

Insulin signaling to hepatic lipid metabolism in health and disease

(2011) Karla F. Leavens et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Lipocalin 13 Protein Protects against Hepatic Steatosis by Both Inhibiting Lipogenesis and Stimulating Fatty Acid β-Oxidation

(2011) Liang Sheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways

(2011) M. Hatori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-term inhibition of SREBP-1c expression reverses diet-induced non-alcoholic fatty liver disease in mice

(2011) Marisa JS Frederico et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

E4BP4: an unexpected player in the immune response

(2011) Victoria Male et al.   TRENDS IN IMMUNOLOGY

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP

(2010) A. K. Walker et al.   GENES & DEVELOPMENT

Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding

(2010) Xin Tong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism

(2010) Bhaskar Ponugoti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives

(2009) B. Viollet et al.   Acta Physiologica

Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance

(2009) Karla F. Leavens et al.   Cell Metabolism

The role of the lipogenic pathway in the development of hepatic steatosis

(2009) C. Postic et al.   DIABETES & METABOLISM

Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c Complex

(2009) Chandrahasa R. Yellaturu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice

(2009) Hélène L. Kammoun et al.   JOURNAL OF CLINICAL INVESTIGATION

Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif

(2009) Y.-K. Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism