Modular Access to 2-(Trifluoromethyl)pyrazolo[1,5-a]pyridines and Their Benzo Analogues through a Copper(I)-Catalyzed Radical Annulation

Copper(I)-Catalyzed Direct Oxidative Annulation of 1,3-Dicarbonyl Compounds with Maleimides: Access to Polysubstituted Dihydrofuran Derivatives

(2022) Wen-Kang Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO-Mediated [3 + 2] Annulation–Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds

(2022) Amu Wang et al.   ORGANIC LETTERS

2,2,2-Trifluoroacetaldehyde O-(Aryl)oxime: A Precursor of Trifluoroacetonitrile

(2022) Bo Lin et al.   ORGANIC LETTERS

Radical philicity and its role in selective organic transformations

(2021) Faeze Parsaee et al.   Nature Reviews Chemistry

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Pyrazolo[1,5-a]pyridine: Recent synthetic view on crucial heterocycles

(2020) Duraipandi Devi Priya et al.   SYNTHETIC COMMUNICATIONS

Current Contributions of Organofluorine Compounds to the Agrochemical Industry

(2020) Yuta Ogawa et al.   iScience

Tandem Aza Michael Addition–Vinylogous Nitroaldol Condensation: Construction of Highly Substituted N-Fused 3-Nitropyrazolopyridines

(2018) Owk Obulesu et al.   JOURNAL OF ORGANIC CHEMISTRY

[3+2] Cycloaddition of N-Aminopyridines and Perfluoroalkynylphosphonates: Facile Synthesis of Perfluoroalkylated Pyrazolo[1,5-a]pyridines Containing a Phosphonate Moiety

(2018) Hui Zhang et al.   SYNTHESIS-STUTTGART

Design, synthesis and cytotoxicity studies of novel pyrazolo[1, 5-a]pyridine derivatives

(2017) Chitrakar Ravi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders

(2017) Satoshi Mikami et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

(2017) Ujjini H. Manjunatha et al.   NATURE

Copper-Promoted Double Oxidative C–H Amination Cascade for the Synthesis of Imidazo[1,5-a]quinolines

(2016) Zhong Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Iodine-catalyzed [3+2] cyclization of 2-pyridylesters and chalcones: metal-free approach for the synthesis of substituted indolizines

(2016) N. Naresh Kumar Reddy et al.   TETRAHEDRON LETTERS

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

(2015) Han-Jie Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

(2015) Claire Le Manach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Copper-mediated synthesis of pyrazolo[1,5-a]pyridines through oxidative linkage of C–C/N–N bonds

(2015) Darapaneni Chandra Mohan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-catalyzed aerobic oxidative amination of C(sp3)–H bonds: synthesis of imidazo[1,5-a]pyridines

(2015) Darapaneni Chandra Mohan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

(2015) Jian Tang et al.   ACS Medicinal Chemistry Letters

An I2-catalyzed oxidative cyclization for the synthesis of indolizines from aromatic/aliphatic olefins and α-picoline derivatives

(2015) Likui Xiang et al.   RSC Advances

Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction

(2014) Xiaoli Zhou et al.   Beilstein Journal of Organic Chemistry

Design and synthesis of spirocyclic compounds as HCV replication inhibitors by targeting viral NS4B protein

(2014) Vincent W.-F. Tai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphodiesterase inhibitors. Part 6: Design, synthesis, and structure–activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity

(2013) Akihiko Kojima et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Novel pyrazolo[1,5-a]pyridines as PI3K inhibitors: variation of the central linker group

(2013) Jackie D. Kendall et al.   MedChemComm

Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia

(2012) Yifeng Xiong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phosphodiesterase inhibitors. Part 4: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones

(2012) Koji Ochiai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant

(2012) Mamta Suri et al.   GREEN CHEMISTRY

Synthesis and Reactions of Pyrazolo[1,5-a]pyridines and Related Heterocycles

(2011) Jackie D. Kendall   CURRENT ORGANIC CHEMISTRY

Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as Melatonin Receptor (MT1/MT2) Ligands

(2011) Tatsuki Koike et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2- and 2,3-Substituted Pyrazolo[1,5-a]pyridines: Scope and Mechanistic Considerations of a Domino Direct Alkynylation and Cyclization ofN-Iminopyridinium Ylides Using Alkenyl Bromides, Alkenyl Iodides, and Alkynes

(2011) James J. Mousseau et al.   JOURNAL OF ORGANIC CHEMISTRY

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents

(2008) Zhonghui Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS