期刊
ORGANIC LETTERS
卷 24, 期 34, 页码 6292-6297出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02500
关键词
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资金
- Guangxi Natural Science Foundation of China [2020GXNSFAA297213]
- Guangxi Science and Technology Base and Special Talents [AD21075017]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources [CMEMR2020-A12]
- Natural Science Foundation of China [22171124]
This paper describes a mechanistically distinctive copper-catalyzed radical annulation reaction that can synthesize valuable 2-(trifluoromethyl)pyrazolo[1,5a]pyridines and their benzo analogues. This complementary process allows the synthesis of 4- or 6-substituted target molecules as a single product, which was previously challenging to access.
A mechanistically distinctive copper-catalyzed radical annulation to valuable 2-(trifluoromethyl)pyrazolo[1,5a]pyridines and their benzo analogues has been described for the first time. Notably, the newly developed complementary process allows the synthesis of 4-or 6-substituted target molecular entities as a single product, which was previously challenging to access by existing methods. The utility of this process is further demonstrated by the facile construction of four different ring systems, a gram scale synthesis, and the late-stage functionalization of bioactive molecules.
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