Article
Biochemistry & Molecular Biology
Le He, Marie-Pierre Valignat, Lichen Zhang, Lena Gelard, Fanghui Zhang, Valentin Le Guen, Stephane Audebert, Luc Camoin, Even Fossum, Bjarne Bogen, Hui Wang, Sandrine Henri, Romain Roncagalli, Olivier Theodoly, Yinming Liang, Marie Malissen, Bernard Malissen
Summary: The study reveals that ARHGAP45 GAP plays a key role in the lifecycle of T and B cells, controlling cell deformability and motility which affect the entry of cells into lymph nodes and engraftment in the bone marrow.
Article
Cell Biology
Lennis Beatriz Orduna-Castillo, Jorge Eduardo del-Rio-Robles, Irving Garcia-Jimenez, Cesar Zavala-Barrera, Yarely Mabell Beltran-Navarro, Joseline Janai Hidalgo-Moyle, Iliana Ramirez-Rangel, Marco A. Hernandez-Bedolla, Alma P. Reyes-Ibarra, Margarita Valadez-Sanchez, Jose Vazquez-Prado, Guadalupe Reyes-Cruz
Summary: The study found that different CaSR mutants identified in breast cancer patients vary in their ability to activate Rac and the mitogenic ERK pathway. Through investigation, it was revealed that CaSR activates Rac and cell migration through the G beta gamma-PI3K-mTORC2 pathway. These findings further support the validation of CaSR as a relevant therapeutic target in metastatic cancer.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemical Research Methods
Miao Guo, Yan Zhang, Lehao Wu, Ye Sheng, Jiaqi Zhao, Zeyuan Wang, Huiyu Wang, Lu Zhang, Hua Xiao
Summary: In this study, a quantitative phosphoproteomics approach was used to investigate the signal transductions upon intracellular BRS3 activation. The results revealed that BRS3 activation downregulates the Hippo signaling pathway, leading to cell migration.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Oncology
Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Takanobu Nakazawa, Hitoshi Hashimoto, James A. A. Waschek, Yukio Ago
Summary: Phosphoinositide metabolism plays a critical role in human cancer cell migration and metastatic growth. This study demonstrates that VIPR2 regulates WAVE2-mediated actin nucleation and elongation for lamellipodium formation through the synthesis of PI(3,4,5)P-3, thereby controlling cancer cell migration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuhong Jiang, Junxian Lim, Kai-Chen Wu, Weijun Xu, Jacky Y. Suen, David P. Fairlie
Summary: This study reveals a novel shared signalling cascade involving Gα(q/11), Gα(12/13), and beta-arrestin1/2 for PAR2-induced ovarian cancer cell migration and invasion, resulting in downstream serial activation of Src kinases, transactivation of EGFR, and subsequent MEK-ERK1/2-FOS/MYC/STAT3-COX2 signalling, which is not dependent on a single G protein or beta-arrestin-mediated pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Virology
Nicholas Davis-Poynter, Helen E. Farrell
Summary: UL33 and US28, encoded by human cytomegalovirus (HCMV), have been found to play a role in placental physiology. They activate trophoblasts through constitutive signaling, promoting migration. UL33 also stimulates the expression of p38 MAP kinase and JNK, with p38 MAP kinase activating CREB and JNK inhibiting CREB activation.
Review
Cell Biology
Shubham Kumar Rai, Divya Singh, Pranita P. P. Sarangi
Summary: RhoG, a member of the Rho family of small GTPases, plays a central role in regulating immune cell functions. Recent research has shown that alterations in RhoG-specific signaling can lead to various diseases. This review highlights the cellular functions of RhoG, interconnections with different signaling pathways, and the potential importance of targeting RhoG in treating pathological conditions.
INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Alan Le Mercier, Remy Bonnavion, Weijia Yu, Mohamad Wessam Alnouri, Sophie Ramas, Yang Zhang, Yannick Jaeger, Kenneth Anthony Roquid, Hyun-Woo Jeong, Kishor Kumar Sivaraj, Haaglim Cho, Xinyi Chen, Boris Strilic, Tjeerd Sijmonsma, Ralf Adams, Timm Schroeder, Michael A. Rieger, Stefan Offemanns
Summary: GPR182 is a new atypical chemokine receptor for CXCL10, CXCL12, and CXCL13, involved in regulating hematopoietic stem cell homeostasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Zeheng Lv, Yan Ding, Wenxin Cao, Shuyun Wang, Kun Gao
Summary: RHO family interacting cell polarization regulators (RIPORs) are a recently discovered protein family that regulate cell functions by suppressing RHO activity. They are phosphorylated by upstream protein kinases, affecting their subcellular localization and interaction with RHO proteins, ultimately impacting cell polarity and migration.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Patrycja Przygodzka, Ewelina Sochacka, Kamila Soboska, Marcin Pacholczyk, Izabela Papiewska-Pajak, Tomasz Przygodzki, Przemyslaw Plocinski, Steven Ballet, An De Prins, Joanna Boncela
Summary: The study found elevated expression of NMU and NMUR2 in CRC tissue samples and variable expression in CRC cell lines. It was shown for the first time that NMUR2 activation induces signaling in CRC cells, and NMU increases motility and invasiveness in NMUR2-positive CRC cells, as well as promoting prometastatic integrin receptor subunit expression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Feng Gao, Panpan Yin, Yanlin Wu, Jinlin Wen, Ying Su, Xinyan Zhang
Summary: The study demonstrated that knockdown of RhoC inhibited OSCC cells invasion and migration in vitro, as well as suppressed OSCC cell growth and lymph node metastasis in vivo. The potential therapeutic target of RhoC in OSCCs may be related to the regulation of HMGA2 expression.
JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sandra A. Hemkemeyer, Veith Vollmer, Vera Schwarz, Birgit Lohmann, Ulrike Honnert, Muna Taha, Hans-Joachim Schnittler, Martin Baehler
Summary: The migration of cells depends on the coordination between Rac-induced actin polymerization and the recruitment of Myo9b, which locally inhibits Rho activity to enhance directional cell migration.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ming-Chieh Lin, Chia-Jung Yu, Fang-Jen S. Lee
Summary: This study reveals that Arl4A/D proteins are stabilized by fibronectin stimulation, promoting their function in cell migration. Phosphorylation modifications and the chaperone protein HYPK are shown to play important roles in the stability and plasma membrane localization of Arl4A/D.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Manuel Delpero, Danny Arends, Aimee Freiberg, Gudrun A. Brockmann, Deike Hesse
Summary: This study used the obese mouse model BFMI861-S1 to identify genetic variants associated with liver weight, body weight, and subcutaneous adipose tissue weight. Through QTL analysis and prioritization, several candidate genes were identified.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Marcello Scala, Masashi Nishikawa, Hidenori Ito, Hidenori Tabata, Tayyaba Khan, Andrea Accogli, Laura Davids, Anna Ruiz, Pietro Chiurazzi, Gabriella Cericola, Bjoern Schulte, Kristin G. Monaghan, Amber Begtrup, Annalaura Torella, Michele Pinelli, Anne Sophie Denomme-Pichon, Antonio Vitobello, Caroline Racine, Maria Margherita Mancardi, Courtney Kiss, Andrea Guerin, Wendy Wu, Elisabeth Gabau Vila, Bryan C. Mak, Julian A. Martinez-Agosto, Michael B. Gorin, Bugrahan Duz, Yavuz Bayram, Claudia M. B. Carvalho, Jaime E. Vengoechea, David Chitayat, Tiong Yang Tan, Bert Callewaert, Bernd Kruse, Lynne M. Bird, Laurence Faivre, Marcella Zollino, Saskia Biskup, Pasquale Striano, Vincenzo Nigro, Mariasavina Severino, Valeria Capra, Gregory Costain, Koh-ichi Nagata
Summary: Variants in RAC3 gene are associated with neurodevelopmental disorder with brain anomalies and facial dysmorphisms. We studied a cohort of 10 patients with various symptoms and found eight distinct de novo RAC3 variants. In vitro analysis showed that these variants have different affinities to downstream effectors and can cause defects in cortical neuron morphology and migration. Our study highlights the significance of RAC3 variants in cortical neuron development.