CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology

DPP4 in Cardiometabolic Disease: Recent Insights From the Laboratory and Clinical Trials of DPP4 Inhibition

(2015) J. Zhong et al.   CIRCULATION RESEARCH

The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74–103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice

(2015) Vincent Vanheule et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

Dipeptidyl-Peptidase IV Activity Is Correlated with Colorectal Cancer Prognosis

(2015) Gorka Larrinaga et al.   PLoS One

Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells

(2014) Diana Röhrborn et al.   FEBS LETTERS

Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection

(2014) Antonio Riva et al.   HEPATOLOGY

Inhibition of CD26/Dipeptidyl Peptidase IV Enhances CCL11/Eotaxin-Mediated Recruitment of Eosinophils In Vivo

(2014) U. Forssmann et al.   JOURNAL OF IMMUNOLOGY

Quantification of Intact and Truncated Stromal Cell-Derived Factor-1α in Circulation by Immunoaffinity Enrichment and Tandem Mass Spectrometry

(2014) Weixun Wang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Increased Plasma DPP4 Activity Is an Independent Predictor of the Onset of Metabolic Syndrome in Chinese over 4 Years: Result from the China National Diabetes and Metabolic Disorders Study

(2014) Fan Yang et al.   PLoS One

Identification and Characterization of Circulating Variants of CXCL12 from Human Plasma: Effects on Chemotaxis and Mobilization of Hematopoietic Stem and Progenitor Cells

(2014) Rudolf Richter et al.   STEM CELLS AND DEVELOPMENT

Glypican-3-mediated inhibition of CD26 by TFPI: a novel mechanism in hematopoietic stem cell homing and maintenance

(2013) S. Khurana et al.   BLOOD

Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types

(2013) X. Ou et al.   BLOOD

Modelling the Sitagliptin Effect on Dipeptidyl Peptidase-4 Activity in Adults with Haematological Malignancies After Umbilical Cord Blood Haematopoietic Cell Transplantation

(2013) Nieves Vélez de Mendizábal et al.   CLINICAL PHARMACOKINETICS

The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation

(2013) Heather O’Leary et al.   CURRENT OPINION IN HEMATOLOGY

CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients

(2013) Dina Ragab et al.   CYTOKINE

Chemokines and other GPCR ligands synergize in receptor-mediated migration of monocyte-derived immature and mature dendritic cells

(2013) Mieke Gouwy et al.   IMMUNOBIOLOGY

Long-term treatment with Sitagliptin, a dipeptidyl peptidase-4 inhibitor, reduces colon carcinogenesis and reactive oxygen species in 1,2-dimethylhydrazine-induced rats

(2013) Angelo Pietro Femia et al.   INTERNATIONAL JOURNAL OF CANCER

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

(2013) V. Stalin Raj et al.   NATURE

Chemokine Expression in Inflamed Adipose Tissue Is Mainly Mediated by NF-κB

(2013) Franck Tourniaire et al.   PLoS One

Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans

(2012) Tiziana Adage et al.   BRITISH JOURNAL OF PHARMACOLOGY

Possible mechanisms involved in chemokine synergy fine tuning the inflammatory response

(2012) Mieke Gouwy et al.   IMMUNOLOGY LETTERS

Overview of the mechanisms regulating chemokine activity and availability

(2012) Anneleen Mortier et al.   IMMUNOLOGY LETTERS

Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis

(2012) Hal E Broxmeyer et al.   NATURE MEDICINE

Structures of Human DPP7 Reveal the Molecular Basis of Specific Inhibition and the Architectural Diversity of Proline-Specific Peptidases

(2012) Gustavo Arruda Bezerra et al.   PLoS One

In Vivo DPP-4 Inhibition to Enhance Engraftment of Single-Unit Cord Blood Transplants in Adults with Hematological Malignancies

(2012) Sherif S. Farag et al.   STEM CELLS AND DEVELOPMENT

Discrimination of agonist and antagonist forms of CXCL10 in biological samples

(2011) A. Casrouge et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

(2011) D. Lamers et al.   DIABETES

DPP-4 Inhibitors: Impact on glycemic control and cardiovascular risk factors

(2011) D. Dicker   DIABETES CARE

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function

(2011) C.L. Salanga et al.   EXPERIMENTAL CELL RESEARCH

Biological Activity of CXCL8 Forms Generated by Alternative Cleavage of the Signal Peptide or by Aminopeptidase-Mediated Truncation

(2011) Anneleen Mortier et al.   PLoS One

The Effect of CXCL12 Processing on CD34+ Cell Migration in Myeloproliferative Neoplasms

(2010) S. Y. Cho et al.   CANCER RESEARCH

Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review

(2010) C. F. Deacon   DIABETES OBESITY & METABOLISM

Effect of posttranslational processing on the in vitro and in vivo activity of chemokines

(2010) Anneleen Mortier et al.   EXPERIMENTAL CELL RESEARCH

Evidence for an antagonist form of the chemokine CXCL10 in patients chronically infected with HCV

(2010) Armanda Casrouge et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo processing of CXCL12α/SDF-1α after intravenous and subcutaneous administration to mice

(2010) Bruno Antonsson et al.   PROTEOMICS

Chemokines in hematopoiesis

(2009) Hal E Broxmeyer   CURRENT OPINION IN HEMATOLOGY

RecognitionVersusAdaptive Up-regulation and Degradation of CC Chemokines by the Chemokine Decoy Receptor D6 Are Determined by Their N-terminal Sequence

(2009) Benedetta Savino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significance of N-Terminal Proteolysis of CCL14a to Activity on the Chemokine Receptors CCR1 and CCR5 and the Human Cytomegalovirus-Encoded Chemokine Receptor US28

(2009) R. Richter et al.   JOURNAL OF IMMUNOLOGY

Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation

(2008) T. Loos et al.   BLOOD

Stromal cell-derived factors 1α and 1β, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8

(2008) Katerina Ajami et al.   FEBS LETTERS

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

(2008) Paul Proost et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of chemokine activity by posttranslational modification

(2008) A MORTIER et al.   PHARMACOLOGY & THERAPEUTICS

The role of CD26/dipeptidyl peptidase IV in cancer

(2007) Pamela et al.   Frontiers in Bioscience-Landmark