Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720

Potential Link between the Sphingosine-1-Phosphate (S1P) System and Defective Alveolar Macrophage Phagocytic Function in Chronic Obstructive Pulmonary Disease (COPD)

(2015) Jameel Barnawi et al.   PLoS One

Coupling between endocytosis and sphingosine kinase 1 recruitment

(2014) Hongying Shen et al.   NATURE CELL BIOLOGY

Oxidative Stress Decreases Functional Airway Mannose Binding Lectin in COPD

(2014) Hai B. Tran et al.   PLoS One

Sphingosine-1–Phosphate, FTY720, and Sphingosine-1–Phosphate Receptors in the Pathobiology of Acute Lung Injury

(2013) Viswanathan Natarajan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cigarette smoke impairs phagocytosis of apoptotic neutrophils by alveolar macrophages via inhibition of the histone deacetylase/Rac/CD9 pathways

(2013) Naotaka Noda et al.   INTERNATIONAL IMMUNOLOGY

Lectins Offer New Perspectives in the Development of Macrophage-Targeted Therapies for COPD/Emphysema

(2013) Violet R. Mukaro et al.   PLoS One

Defective Lung Macrophage Function in Lung Cancer±Chronic Obstructive Pulmonary Disease (COPD/Emphysema)-Mediated by Cancer Cell Production of PGE2?

(2013) Francis C. Dehle et al.   PLoS One

Fingolimod Therapy for Multiple Sclerosis

(2013) Mary Willis et al.   SEMINARS IN NEUROLOGY

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Involvement of protein kinase D in uridine diphosphate-induced microglial macropinocytosis and phagocytosis

(2012) Ayumi Uesugi et al.   GLIA

Low-dose azithromycin improves phagocytosis of bacteria by both alveolar and monocyte-derived macrophagesin chronic obstructive pulmonary disease subjects

(2012) SANDRA HODGE et al.   RESPIROLOGY

Expression profile of the sphingosine kinase signalling system in the lung of patients with chronic obstructive pulmonary disease

(2011) Fabian Cordts et al.   LIFE SCIENCES

Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages

(2011) T. McQuiston et al.   MICROBIOLOGY-SGM

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

(2010) Francesca Tonelli et al.   CELLULAR SIGNALLING

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration

(2010) Graham M. Strub et al.   FASEB JOURNAL

Sphingolipid-mediated Inhibition of Apoptotic Cell Clearance by Alveolar Macrophages

(2010) Daniela N. Petrusca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate

(2010) Deanna L. Siow et al.   JOURNAL OF LIPID RESEARCH

Export and functions of sphingosine-1-phosphate

(2009) Roger H. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

(2009) Evgeny V. Berdyshev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation

(2009) M. P. Kuehnel et al.   JOURNAL OF CELL SCIENCE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Azithromycin Improves Macrophage Phagocytic Function and Expression of Mannose Receptor in Chronic Obstructive Pulmonary Disease

(2008) Sandra Hodge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS