Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Article
Medicine, General & Internal
Randy Coupet, Martin Schlaepfer, Thomas A. Neff, Pierre Boucher, Pierre Bailly, Martin Bellgardt, Rafael Badenes, Jose Carbonell, Tobias Becher, Caroline Varillon, Dominique Morand, Raiko Blondonnet, Jean-Michel Constantin, Bruno Pereira, Brian O'Gara, Matthieu Jabaudon
Summary: This study investigated 196 COVID-19 ARDS patients from 10 intensive care units in Europe and the US in 2021. The results showed that inhaled sedation did not significantly improve the number of ventilator-free days compared to intravenous sedation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Lieuwe D. J. Bos, Michael Sjoding, Pratik Sinha, Sivasubramanium Bhavani, Patrick G. Lyons, Alice F. Bewley, Michela Botta, Anissa M. Tsonas, Ary Serpa Neto, Marcus J. Schultz, Robert P. Dickson, Frederique Paulus
Summary: This study aimed to identify respiratory subphenotypes of COVID-19-related ARDS using data-driven approaches. While no consistent subphenotypes were identified at baseline, two distinct subphenotypes were found during the first 4 days of invasive mechanical ventilation. These subphenotypes demonstrated differences in patient outcomes, indicating the importance of subtyping in the progression and outcomes of ARDS patients.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Sarah Benghanem, Alain Cariou, Jean-Luc Diehl, Angela Marchi, Julien Charpentier, Jean-Loup Augy, Caroline Hauw-Berlemont, Martine Gavaret, Frederic Pene, Jean-Paul Mira, Tarek Sharshar, Bertrand Hermann
Summary: Acute cerebral dysfunction is common in COVID-19 ARDS patients. An early clinical and EEG assessment can predict outcomes, particularly delayed awakening, delirium, and day-28 mortality.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Yoann Zerbib, Alexis Lambour, Julien Maizel, Loay Kontar, Bertrand De Cagny, Thierry Soupison, Thomas Bradier, Michel Slama, Clement Brault
Summary: The study found that high recruitability patients showed a significant increase in respiratory system compliance after lung recruitment maneuvers, while low recruitability patients experienced a decrease in pulse pressure, potentially indicating a drop in cardiac output.
Article
Multidisciplinary Sciences
Christian M. Jensen, Junia C. Costa, Jens C. Norgaard, Adrian G. Zucco, Bastian Neesgaard, Carsten U. Niemann, Sisse R. Ostrowski, Joanne Reekie, Birgit Holten, Anna Kalhauge, Michael A. Matthay, Jens D. Lundgren, Marie Helleberg, Kasper S. Moestrup
Summary: The existing chest X-ray (CXR)-based scoring systems for COVID-19 pneumonia have low spatial resolution, which needs to be increased for better evaluation of lung anatomy and severity. In this study, the MBrixia score was developed by modifying the Brixia score to improve spatial resolution. The MBrixia score, based on a rule-based quantification of CXR severity in 12 anatomical zones, was applied to CXR images of COVID-19 patients. The results showed a positive correlation between the MBrixia score and the level of respiratory support at the time of CXR imaging. The MBrixia score has the potential to serve as a quantitative surrogate measurement of COVID-19 pneumonia severity, and further research should investigate its validity and predictive capabilities for clinical outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Gema Villa Lopez, Maria Angeles Valero Zanuy, Ivan Gonzalez Barrios, Maria Maiz Jimenez, Pilar Gomis Munoz, Miguel Leon Sanz
Summary: The incidence of hypertriglyceridemia in critically ill patients with ARDS-COVID-19 receiving PN was 37 cases per 100 patient-days. Risk factors for this complication included obesity and the use of lopinavir/ritonavir or Propofol. Patients with hypertriglyceridemia required longer duration of PN support, but it did not affect mortality rates.
Article
Respiratory System
Cecilia Lopez-Martinez, Paula Martin-Vicente, Juan Gomez de Ona, Ines Lopez-Alonso, Helena Gil-Pena, Elias Cuesta-Llavona, Margarita Fernandez-Rodriguez, Irene Crespo, Estefania Salgado del Riego, Raquel Rodriguez-Garcia, Diego Parra, Javier Fernandez, Javier Rodriguez-Carrio, Francisco Jose Jimeno-Demuth, Alberto Davalos, Luis A. Chapado, Eliecer Coto, Guillermo M. Albaiceta, Laura Amado-Rodriguez
Summary: In this study, researchers identified two transcriptomic clusters in critically ill COVID-19 patients based on peripheral blood transcriptomes. One cluster was characterized by interferon-related expression and the other promoted B-cell activation. These clusters had different ICU outcomes, suggesting different pathogenetic mechanisms. The findings demonstrate the potential of transcriptomics in identifying patient endotypes for personalized therapies in severe COVID-19.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Clinical Neurology
Andrew J. Michalak, Anil Mendiratta, Andrey Eliseyev, Brian Ramnath, Jane Chung, Jarret Rasnow, Lawrence Reid, Steven Salerno, Paul S. Garcia, Sachin Agarwal, David Roh, Soojin Park, Carl Bazil, Jan Claassen
Summary: The study investigated if limited frontotemporal EEG can guide sedation changes in COVID-19 patients receiving neuromuscular blocking agent. Results showed that EEG can assist in adjusting sedation levels, and a machine learning algorithm achieved a certain level of accuracy in automatically classifying sedation levels.
CLINICAL NEUROPHYSIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Multidisciplinary Sciences
Ahmed S. Doghish, Walid F. Elkhatib, Essam A. Hassan, Ahmed F. Elkhateeb, Eman E. Mahmoud, Mona Ahmed, Mahmoud A. F. Khalil
Summary: This study aimed to describe the clinical characteristics of COVID-19 patients with ARDS, revealing that patients presented with lymphopenia, increased thrombotic activity, increased CRP, LDH, and ferritin levels. The results showed significant associations between CRP, D-dimer, LDH levels, and lymphopenia with COVID-19 severity, indicating their potential as biomarkers for predicting disease severity.
Article
Critical Care Medicine
Prashant Nasa, Elie Azoulay, Ashish K. Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M. Arabi, Jan Bakker, Laurent J. Brochard, Adam M. Deane, Bin Du, Sharon Einav, Andres Esteban, Ognjen Gajic, Samuel M. Galvagno, Claude Guerin, Samir Jaber, Gopi C. Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R. Machado, Manu L. N. G. Malbrain, Jordi Mancebo, Michael T. McCurdy, Brendan A. McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K. Park, Paolo Pelosi, John V. Peter, Jason Phua, David V. Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J. Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A. Udy, Tobias Welte, Sheila N. Myatra
Summary: A study was conducted using the Delphi process to develop clinical practice statements on the respiratory management of COVID-19-related acute respiratory failure. A total of 27 management strategies were agreed upon by experts, leading to the development of 20 expert clinical practice statements. Experts unanimously agreed that COVID-19-related acute respiratory distress syndrome is clinically similar to other forms of ARDS.
Review
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey P. Kanne, Brent P. Little, Jefree J. Schulte, Adina Haramati, Linda B. Haramati
Summary: In the 3rd year of the SARS-CoV-2 pandemic, it has been found that about one-third of patients with moderate-to-severe pneumonia, especially those who required intensive care or mechanical ventilation, have residual abnormalities in their lungs one year after initial presentation. These abnormalities range from parenchymal bands to bronchial dilation to fibrosis. The long-term pulmonary vascular sequelae are not well understood, but there seems to be a persistent increased risk of venothromboembolic events in a small group of patients. The histologic abnormalities associated with SARS-CoV-2 infection are similar to those seen in patients with acute lung injury from other causes.
Article
Critical Care Medicine
Adriano Bernini, Sandra Magnoni, John-Paul Miroz, Ricardo Corredor-Jerez, Guido Bertolini, Henrik Zetterberg, Neil Graham, David Sharp, Mauro Oddo, Vincent Dunet
Summary: This study investigated the association between acute post-traumatic cerebral metabolic dysfunction and 1-year gray matter atrophy following TBI. The results showed that the CMD LP ratio was strongly correlated with the total GM volume change rate at 1 year, indicating the importance of CMD LP ratio as an early biomarker for poor long-term recovery after TBI.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Florence M. Aellen, Sigurd L. Alnes, Fabian Loosli, Andrea O. Rossetti, Frederic Zubler, Marzia De Lucia, Athina Tzovara
Summary: Assessing neural functions in coma after cardiac arrest is challenging. Prognostication based on visual expert scoring of physiological signals is subjective and leaves many patients with uncertain prognosis. This study suggests that convolutional neural networks can extract interpretable patterns of EEG responses to auditory stimuli during the first day of coma, predicting patients' chances of awakening and survival at 3 months.
Article
Clinical Neurology
Sara Carta, Alvaro Cobo Calvo, Thais Armangue, Albert Saiz, Christian Lechner, Kevin Rostasy, Markus Breu, Matthias Baumann, Romana Hoeftberger, Ilya Ayzenberg, Carolin Schwake, Maria Sepulveda, Eugenia Martinez-Hernandez, Gemma Olive-Cirera, Georgina Arrambide, Mar Tintore, Raphael Bernard-Valnet, Renaud Du Pasquier, Fabienne Brilot, Sudarshini Ramanathan, Kathrin Schanda, Alberto Gajofatto, Sergio Ferrari, Elia Sechi, Eoin P. Flanagan, Sean J. Pittock, Vyanka Redenbaugh, Markus Reindl, Romain Marignier, Sara Mariotto
Summary: This study aimed to investigate the clinical relevance of cerebrospinal fluid (CSF) myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) positivity. The findings suggest that CSF MOG-Abs positivity is associated with more severe clinical presentation and worse outcomes.
Article
Critical Care Medicine
Helene Fenter, Nawfel Ben-Hamouda, Jan Novy, Andrea O. Rossetti
Summary: The current EEG evaluation for prognosis after cardiac arrest focuses on identifying patients with poor prognosis, but has limited sensitivity in detecting patients with good prognosis. Modifying the definition of benign EEG may improve sensitivity in detecting patients with favorable outcomes.
Article
Clinical Neurology
Amandine Mathias, Vasiliki Pantazou, Sylvain Perriot, Mathieu Canales, Samuel Jones, Larise Oberholster, Michael Moulin, Craig Fenwick, Raphael Bernard-Valnet, Marie Theaudin, Caroline Pot, Renaud A. Du Pasquier
Summary: This study aims to investigate the impact of ocrelizumab (OCRE) on immune cell subsets in patients with multiple sclerosis (pwMS). The results showed that OCRE not only depletes B cells, but also reduces memory CD8(+) T cells, which may increase the risk of infections. Therefore, clinicians should pay special attention to the increased infection risk when switching pwMS from other disease-modifying therapies (DMTs) to OCRE.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Ian Kuffer, Jan Novy, Andrea O. Rossetti
Summary: This study retrospectively analyzed the impact of loading doses of levetiracetam (LEV) on the prognosis of status epilepticus (SE). The results showed that lower doses of LEV loading were not associated with worse clinical outcomes, challenging current guidelines. Further prospective studies are needed to investigate this issue in depth.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Raphael Bernard-Valnet, Renaud A. Du Pasquier
Article
Clinical Neurology
Andria Tziakouri, Jan Novy, Nawfel Ben-Hamouda, Andrea O. Rossetti
Summary: This study investigated the association between serum neuron specific enolase (NSE) and electroencephalogram (EEG) after cardiac arrest. The results showed that higher NSE levels were associated with poor EEG prognosticators such as increasing malignancy, repetitive epileptiform discharges, and lack of background reactivity. The relationship between epileptiform discharges and NSE was influenced by EEG background and timing.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Valentin Loser, Jan Novy, Isabelle Beuchat, Andrea O. Rossetti
Summary: This study aims to characterize the frequency and clinico-biological characteristics of valproate-induced encephalopathy (VIE) in adult patients with status epilepticus (SE). The study found that VIE is relatively common and difficult to predict in SE patients, and clinical awareness of symptoms is necessary even without hyperammonemia, with consideration for valproate withdrawal in suspected cases.
Letter
Clinical Neurology
Vincent Alvarez, Jan Novy, Isabelle Beuchat, Andrea O. Rossetti
Review
Clinical Neurology
Tamar Akhvlediani, Raphael P. Bernard-Valnet, Sara Dias, Randi Eikeland, Bettina Pfausler, Johann Sellner
Summary: This article summarizes the available knowledge about antiviral drugs against SARS-CoV-2 from a neurologist's perspective. The findings suggest that neurological side effects and drug interactions must be considered for the antiviral treatment of SARS-CoV-2. Further research is needed to evaluate the efficacy and adverse events of these drugs in patients with neurological diseases.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tristan Born, Paola Vassallo, Dela Golshayan, Giovanni Di Liberto, Jean-Philippe Brouland, Kristof Egervari, Doron Merkler, Renaud A. Du Pasquier, Raphael Bernard-Valnet
Summary: This article reports a case of a kidney transplant recipient developing PML and receiving recombinant human interleukin 7 for immune responses against JCV. The article provides an overview of the immune mechanisms underlying PML development and immune restoration within the CNS after JCV infection. Immunotherapeutic strategies based on current understanding of the disease hold promise in managing PML patients.
Meeting Abstract
Clinical Neurology
Raphael Bernard-Valnet, Julie Blant, Nicola De Rossi, Christoph Schroeder, Aude Maurousset, Markus Kraemer, Kodai Kume, Tatsuro Misu, Jean Ouallet, Maud Pallix Guyot, Ralf Gold, Simonetta Gerevini, Ilya Ayzenberg, Renaud Du Pasquier
Meeting Abstract
Clinical Neurology
H. Fenter, N. Jan, N. Ben Hamouda, A. O. Rossetti