Article
Virology
Enric Monreal, Sainz S. de la Maza, Pedro Gullon, Elena Natera-Villalba, Juan Luis Chico-Garcia, Alvaro Beltran-Corbellini, Javier Martinez-Sanz, Nuria Garcia-Barragan, Javier Buisan, Rafael Toledano, Araceli Alonso-Canovas, Paula Perez-Torre, Maria C. Matute-Lozano, Jose Luis Lopez-Sendon, Guillermo Garcia-Ribas, Inigo Corral, Jesus Fortun, Beatriz Montero-Errasquin, Luis Manzano, Luis Maiz-Carro, Lucienne Costa-Frossard, Jaime Masjuan
Summary: This study found that immunosuppression may reduce the risk of moderate to severe ARDS in COVID-19 patients, especially among those with autoimmune diseases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Critical Care Medicine
Yaseen M. Arabi, Dunia Jawdat, Ali H. Hajeer, Musharaf Sadat, Jesna Jose, Ramesh K. Vishwakarma, Walid Almashaqbeh, Abdulaziz Al-Dawood
Summary: This study evaluated the inflammatory response in patients with severe acute respiratory infection due to the Middle East respiratory syndrome and non-Middle East respiratory syndrome, and identified two distinct inflammatory subtypes using latent class analysis. The findings showed that a subset of patients exhibited increased levels of interleukins, indicative of a cytokine storm. Further research is needed to explore the effects of immunomodulators on different inflammatory subtypes.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Morgan Caplan, Julien Goutay, Anne Bignon, Emmanuelle Jaillette, Raphael Favory, Daniel Mathieu, Erika Parmentier-Decrucq, Julien Poissy, Thibault Duburcq
Summary: The study found that infusion of Almitrine improved oxygenation in patients with acute respiratory distress syndrome induced by severe acute respiratory syndrome coronavirus 2, without adverse effects. Patients who responded positively to Almitrine had better prognosis, suggesting Almitrine could be an interesting therapeutic option in managing severe hypoxemia.
CRITICAL CARE MEDICINE
(2021)
Review
Microbiology
Chao Quan, Caiyan Li, Han Ma, Yisha Li, Huali Zhang
Summary: This review summarizes the epidemiology, clinical features, virology, and host immune responses of SARS-CoV, MERS-CoV, and SARS-CoV-2, highlighting the potential immunopathological effects of highly pathogenic coronaviruses and discussing potential therapeutic implications for combating severe coronavirus infections.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Pediatrics
Tina Hsu, Jacquelyn R. Sink, Veronica Alaniz, Lida Zheng, Anthony J. Mancini
Summary: The study described three cases of acute genital ulceration in female patients after receiving COVID-19 vaccination or natural infection, confirming the possible association between ulceration and viral infection.
JOURNAL OF PEDIATRICS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Letter
Immunology
Nadine Muller, Mareike Kunze, Fabienne Steitz, Neil J. Saad, Barbara Muehlemann, Joern I. Beheim-Schwarzbach, Julia Schneider, Christian Drosten, Lukas Murajda, Sandra Kochs, Claudia Ruscher, Jan Walter, Nadine Zeitlmann, Victor M. Corman
Summary: An outbreak of coronavirus disease with 74 cases related to a nightclub in Germany in March 2020 highlighted the potential for superspreader events, with staff members being particularly affected (56% attack rate) and likely causing sustained viral transmission after an event at the club. This event supports the current club closures as a precautionary measure to prevent further spread of the virus.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Armin Niklas Flinspach, Sebastian Zinn, Kai Zacharowski, Uemniye Balaban, Eva Herrmann, Elisabeth Hannah Adam
Summary: This study aimed to evaluate whether the patient sedation index (PSI) obtained via processed electroencephalography (pEEG) can adequately reflect sedation in ventilated COVID-19 patients. The results showed a distinct discrepancy between the Richmond Agitation and Sedation Scale (RASS) and the determined PSI, but the reasons for this discrepancy remain unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Infectious Diseases
Le-Le Wang, Jia-Wei Yang, Jin-Fu Xu
Summary: This article reviews the mechanisms of lung inflammation and injury caused by SARS-CoV-2 infection, including cellular inflammation, cytokine storm, and thrombotic inflammation.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Multidisciplinary Sciences
Aziza Kantri, Jihane Ziati, Mohamed Khalis, Amal Haoudar, Karim El Aidaoui, Youssef Daoudi, Inas Chikhaoui, Khalid El Yamani, Mohammed Mouhaoui, Jalila El Bakkouri, Nezha Dini, Mohammed Mahi, Abdelhamid Naitlho, Abdelkrim Bahlaoui, Ahmed Bennana, Mustapha Noussair, Lahcen Belyamani, Chafik El Kettani
Summary: This study critically analyzed the clinical and biological characteristics of 134 patients from the North African Mediterranean region with COVID-19, finding that factors such as age, comorbidities, gender, and infection type were associated with disease progression to a severe state. Abnormalities in certain parameters were closely linked to disease deterioration.
Article
Multidisciplinary Sciences
Tarek Bayyoud, Angelika Iftner, Thomas Iftner, Karl Ulrich Bartz-Schmidt, Focke Ziemssen, Hans Boesmueller, Falko Fend, Jens Martin Rohrbach, Marius Ueffing, Michael Schindler, Sebastian Thaler
Summary: This study examined the retinal tissue and vitreous of deceased COVID-19 patients for the presence of SARS-CoV-2 RNA and found no significant viral RNA levels. Histopathological examinations showed no morphological signs of inflammation or vessel occlusions in the retina and vitreous. Further research is needed to confirm or refute these findings.
Article
Critical Care Medicine
Mehdi C. Shelhamer, Paul D. Wesson, Ian L. Solari, Deanna L. Jensen, William Alex Steele, Vihren G. Dimitrov, John Daniel Kelly, Shazia Aziz, Victor Perez Gutierrez, Eric Vittinghoff, Kevin K. Chung, Vidya P. Menon, Herman A. Ambris, Sanjiv M. Baxi
Summary: Prone positioning in patients with moderate to severe ARDS due to COVID-19 is associated with reduced mortality and improved physiologic parameters, with one in-hospital death averted for every 8 patients treated. The results suggest that prone positioning may represent an additional therapeutic option in patients with ARDS due to COVID-19, but further replication and scaling of the intervention are important.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Respiratory System
Evdokia Gavrielatou, Katerina Vaporidi, Vasiliki Tsolaki, Nikos Tserlikakis, George E. Zakynthinos, Eleni Papoutsi, Aikaterini Maragkuti, Athina G. Mantelou, Dimitrios Karayiannis, Zafeiria Mastora, Dimitris Georgopoulos, Epaminondas Zakynthinos, Christina Routsi, Spyros G. Zakynthinos, Edward J. Schenck, Anastasia Kotanidou, Ilias I. Siempos
Summary: Rapidly improving ARDS is not prevalent and is not associated with good prognosis among patients with COVID-19. Persistent severe ARDS has a higher prevalence and mortality rate.
RESPIRATORY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Andrey Eliseyev, Tetiana Aksenova
Article
Medicine, Research & Experimental
Thomas Costecalde, Tetiana Aksenova, Napoleon Torres-Martinez, Andriy Eliseyev, Corinne Mestais, Cecile Moro, Alim Louis Benabid
Article
Multidisciplinary Sciences
Andrey Eliseyev, Vincent Auboiroux, Thomas Costecalde, Lilia Langar, Guillaume Charvet, Corinne Mestais, Tetiana Aksenova, Alim-Louis Benabid
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Lukas Mees, Jonathan Fidler, Matthias Kreuzer, Jieming Fu, Machelle T. Pardue, Paul S. Garcia
Article
Medicine, General & Internal
Jan Claassen, Kevin Doyle, Adu Matory, Caroline Couch, Kelly M. Burger, Angela Velazquez, Joshua U. Okonkwo, Jean-Remi King, Soojin Park, Sachin Agarwal, David Roh, Murad Megjhani, Andrey Eliseyev, E. Sander Connolly, Benjamin Rohaut
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Clinical Neurology
Alim Louis Benabid, Thomas Costecalde, Andrey Eliseyev, Guillaume Charvet, Alexandre Verney, Serpil Karakas, Michael Foerster, Aurelien Lambert, Boris Moriniere, Neil Abroug, Marie-Caroline Schaeffer, Alexandre Moly, Fabien Sauter-Starace, David Ratel, Cecile Moro, Napoleon Torres-Martinez, Lilia Langar, Manuela Oddoux, Mircea Polosan, Stephane Pezzani, Vincent Auboiroux, Tetiana Aksenova, Corinne Mestais, Stephan Chabardes
Letter
Clinical Neurology
Ayham Alkhachroum, Andrey Eliseyev, Caroline A. Der-Nigoghossian, Clio Rubinos, Julie Anne Kromm, Elizabeth Mathews, Andrew Bauerschmidt, Kevin Doyle, Angela Velasquez, Jennifer A. Egbebike, Anna R. Calderon, David J. Roh, Soojin Park, Sachin Agarwal, Edward Sander Connolly, Jan Claassen
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Andrey Eliseyev, Ian Jerome Gonzales, Anh Le, Kevin Doyle, Jennifer Egbebike, Angela Velazquez, Sachin Agarwal, David Roh, Soojin Park, E. Sander Connolly, Jan Claassen
Summary: This study aims to develop a self-paced BCI system for patients in intensive care units, with initial results showing that more than one third of conscious ICU patients and all healthy volunteers were able to control the self-paced BCI system, while the unconscious patients were not able to perform the task. Future studies will focus on the ability of behaviorally unresponsive patients with cognitive motor dissociation to control the self-paced BCI system.
Article
Neurosciences
Christopher G. Sinon, Amy Ottensmeyer, Austin N. Slone, Dan C. Li, Rachael S. Allen, Machelle T. Pardue, Paul S. Garcia
Summary: Diabetes is a strong predictor of postoperative delirium and functional decline in older patients undergoing surgery. Exercise is hypothesized to reduce the risk of postoperative cognitive impairments. Prehabilitation with moderate intensity exercise can improve recovery from anesthesia and cognitive function, regardless of metabolic disease status.
NEUROSCIENCE LETTERS
(2021)
Article
Engineering, Biomedical
A. Eliseyev, T. Aksenova
BRAIN-COMPUTER INTERFACES
(2019)
Article
Multidisciplinary Sciences
Benjamin Rohaut, Kevin W. Doyle, Alexandra S. Reynolds, Kay Igwe, Caroline Couch, Adu Matory, Batool Rizvi, David Roh, Angela Velazquez, Murad Megjhani, Soojin Park, Sachin Agarwal, Christine M. Mauro, Gen Li, Andrey Eliseyev, Vincent Perlbarg, Sander Connolly, Adam M. Brickman, Jan Claassen
SCIENTIFIC REPORTS
(2019)
Review
Critical Care Medicine
Benjamin Rohaut, Andrey Eliseyev, Jan Claassen
Proceedings Paper
Acoustics
Sarah Engel, Tetiana Aksenova, Andrey Eliseyev
LATENT VARIABLE ANALYSIS AND SIGNAL SEPARATION (LVA/ICA 2017)
(2017)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)