Article
Microbiology
Shuchen Feng, Amornrat O'Brien, Da-Yuan Chen, Mohsan Saeed, Susan C. Baker
Summary: We recently reported a surprising role for nsp6 replicase component, in addition to spike changes, in the attenuation of Omicron BA.1. We documented a triple-amino-acid deletion in a predicted lumenal domain of nsp6 found in multiple variants of SARS-CoV-2, including all recent Omicron lineages. Modeling the predicted structure of nsp6 revealed a conserved multipass transmembrane architecture in the Coronaviridae family.
Review
Physiology
Geoffroy Vellieux, Romain Sonneville, Serafima Vledouts, Pierre Jaquet, Anny Rouvel-Tallec, Marie-Pia d'Ortho
Summary: SARS-CoV-2, responsible for COVID-19, not only affects the respiratory system but also leads to neurological manifestations, with EEG studies showing various abnormalities. The mechanisms behind brain injury in COVID-19 are still unknown, but the hypothesis of frontal EEG abnormalities has gained support.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Lei Tang, Shixin Liu, Yanhe Xiao, Thi My Linh Tran, Ji Whae Choi, Jing Wu, Kasey Halsey, Raymond Y. Huang, Jerrold Boxerman, Sohil H. Patel, David Kung, Renyu Liu, Michael D. Feldman, Daniel D. Danoski, Wei-hua Liao, Scott E. Kasner, Tao Liu, Bo Xiao, Paul J. Zhang, Michael Reznik, Harrison X. Bai, Li Yang
Summary: Neurologic symptoms at admission, particularly the presence of encephalopathy, can predict adverse outcomes in patients with SARS-CoV-2 infection. Risk stratification based on the severity of encephalopathy may be helpful in clinical practice.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Md. Saidul Islam, Masahiro Fukuda, Md. Jakir Hossain, Nurun Nahar Rabin, Ryuta Tagawa, Mami Nagashima, Kenji Sadamasu, Kazuhisa Yoshimura, Yoshihiro Sekine, Terumasa Ikeda, Shinya Hayami
Summary: This study demonstrates the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by pH-dependent graphene oxide (GO) nanosheets. The research shows that GO dispersions with higher pH exhibit better virus inactivation compared to neutral or lower pH GO. This can be attributed to the pH-driven functional group change and the overall charge of GO, facilitating the attachment between GO nanosheets and virus particles.
NANOSCALE ADVANCES
(2023)
Correction
Multidisciplinary Sciences
Enrico Lavezzo, Elisa Franchin, Constanze Ciavarella, Gina Cuomo-Dannenburg, Luisa Barzon, Claudia Del Vecchio, Lucia Rossi, Riccardo Manganelli, Arianna Loregian, Nicolo Navarin, Davide Abate, Manuela Sciro, Stefano Merigliano, Ettore De Canale, Maria Cristina Vanuzzo, Valeria Besutti, Francesca Saluzzo, Francesco Onelia, Monia Pacenti, Saverio G. Parisi, Giovanni Carretta, Daniele Donato, Luciano Flor, Silvia Cocchio, Giulia Masi, Alessandro Sperduti, Lorenzo Cattarino, Renato Salvador, Michele Nicoletti, Federico Caldart, Gioele Castelli, Eleonora Nieddu, Beatrice Labella, Ludovico Fava, Matteo Drigo, Katy A. M. Gaythorpe, Alessandra R. Brazzale, Stefano Toppo, Marta Trevisan, Vincenzo Baldo, Christl A. Donnelly, Neil M. Ferguson, Ilaria Dorigatti, Andrea Crisanti, Andrea Crisanti
Summary: The correction to this paper has been published.
Article
Clinical Neurology
Kaitlin M. Seibert, Wonhee Lee, Alexandra Eid, Amy E. Espinal, Sara A. Klein, Sumayyah K. Abumurad, James X. Tao, Naoum P. Issa
Summary: This study aims to assess the risk factors for encephalopathy in non-ICU hospitalized patients with COVID-19 and the impact of encephalopathy on short-term outcomes. The results suggest that encephalopathy is a major determinant of poor short-term outcomes in non-ICU hospitalized patients with COVID-19.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Jonas Schuhenn, Toni Luise Meister, Daniel Todt, Thilo Bracht, Karin Schork, Jean-Noel Billaud, Carina Elsner, Natalie Heinen, Zehra Karakoese, Sibylle Haid, Sriram Kumar, Linda Brunotte, Martin Eisenacher, Yunyun Di, Jocelyne Lew, Darryl Falzarano, Jieliang Chen, Zhenghong Yuan, Thomas Pietschmann, Bettina Wiegmann, Hendrik Uebner, Christian Taube, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Adalbert Krawczyk, Stephan Ludwig, Barbara Sitek, Eike Steinmann, Ulf Dittmer, Kerry J. Lavender, Kathrin Sutter, Stephanie Pfaender
Summary: This study found that different subtypes of IFN-alpha have varying antiviral activity against SARS-CoV-2, with IFN-alpha 5 showing the highest efficacy. Combination treatment with the broad antiviral drug remdesivir enhanced the antiviral effect. These findings are important for understanding the mechanism of IFN-I-mediated antiviral response and developing treatments for COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Ryuta Uraki, Maki Kiso, Shun Iida, Masaki Imai, Emi Takashita, Makoto Kuroda, Peter J. Halfmann, Samantha Loeber, Tadashi Maemura, Seiya Yamayoshi, Seiichiro Fujisaki, Zhongde Wang, Mutsumi Ito, Michiko Ujie, Kiyoko Iwatsuki-Horimoto, Yuri Furusawa, Ryan Wright, Zhenlu Chong, Seiya Ozono, Atsuhiro Yasuhara, Hiroshi Ueki, Yuko Sakai-Tagawa, Rong Li, Yanan Liu, Deanna Larson, Michiko Koga, Takeya Tsutsumi, Eisuke Adachi, Makoto Saito, Shinya Yamamoto, Masao Hagihara, Keiko Mitamura, Tetsuro Sato, Masayuki Hojo, Shin-ichiro Hattori, Kenji Maeda, Riccardo Valdez, Moe Okuda, Jurika Murakami, Calvin Duong, Sucheta Godbole, Daniel C. Douek, Ken Maeda, Shinji Watanabe, Aubree Gordon, Norio Ohmagari, Hiroshi Yotsuyanagi, Michael S. Diamond, Hideki Hasegawa, Hiroaki Mitsuya, Tadaki Suzuki, Yoshihiro Kawaoka
Summary: The replicative ability and pathogenicity of Omicron BA.2 variant is similar to that of BA.1 in rodents, but it shows less pathogenicity compared to early SARS-CoV-2 strains. There is a marked reduction in the neutralizing activity of plasma from individuals who had recovered from COVID-19 and vaccine recipients against BA.2 variant.
Review
Medicine, General & Internal
Santosh Singh, Nikita Meher, Arifullah Mohammed, Mohammad Khairul Azhar Abdul Razab, L. V. K. S. Bhaskar, Norazlina Mat Nawi
Summary: The coronavirus primarily affects the respiratory system but can also damage other organs such as the kidneys, cardiovascular system, and gastrointestinal system. Recent reports have shown that it can also affect the central and peripheral nervous systems, leading to various neurological complications. The virus can enter the brain through the blood-brain barrier or directly through specific receptors, resulting in symptoms such as headache, dizziness, encephalopathy, cerebrovascular disease, loss of smell and taste, and muscle damage. This review article provides insights into the routes and mechanisms of nervous system infection and highlights the range of neurological complications of COVID-19, which can help improve clinical treatment and reduce mortality rates.
Article
Anesthesiology
Lisa Hentsch, Patrick Stancu, Gilles Allali, Karl-Olof Lovblad, Johannes A. Lobrinus, Sara Cocetta, Sophie Pautex, Marjolaine Uginet, Jacques Serratrice, Matteo Coen
Summary: The article reports three cases of chronic cancer pain patients experiencing a significant reduction or disappearance of pain when infected with COVID-19, with pain reappearing after recovery. Neurological imaging and pathological findings did not provide conclusive results. The authors believe further investigation is essential for shedding new light on pain perception and modulation mechanisms.
Article
Multidisciplinary Sciences
John M. M. O'Toole, Sean R. R. Mathieson, Sumit A. A. Raurale, Fabio Magarelli, William P. P. Marnane, Gordon Lightbody, Geraldine B. B. Boylan
Summary: This report presents a dataset of neonatal electroencephalogram (EEG) recordings graded based on the severity of abnormalities in the background pattern. The dataset includes 169 hours of multi-channel EEG from 53 neonates diagnosed with hypoxic-ischaemic encephalopathy (HIE). The grading system assesses attributes such as amplitude, continuity, sleep-wake cycling, symmetry and synchrony, and abnormal waveforms to categorize the background severity into 4 grades. The dataset can be used for reference, training, and algorithm development for neonatal EEG with HIE.
Article
Biology
John M. Drake, Pej Rohani, Kyle Dahlin, Andreas Handel
Summary: Research findings suggest that alternative approaches to suppression may be effective, but require extensive testing and work within a relatively narrow range of conditions. General protective measures such as wearing face masks and improving hygiene are found to significantly enhance the effectiveness of targeted interventions.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Jie Bai, Asako Chiba, Goh Murayama, Taiga Kuga, Naoto Tamura, Sachiko Miyake
Summary: The effects of sex, age, and ethnic background on the immune responses elicited by the mRNA vaccine were investigated. Vaccine-induced antibody and T cell responses declined over time but persisted after 3 months. The reactivity of adaptive immune responses against variants was influenced by different HLA haplotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Franziska R. Traube, Marcel Stern, Annika J. Toelke, Martina Rudelius, Ernesto Mejias-Perez, Nada Raddaoui, Beate M. Kuemmerer, Celine Douat, Filipp Streshnev, Manuel Albanese, Paul R. Wratil, Yasmin Gaertner, Milda Nainyte, Grazia Giorgio, Stylianos Michalakis, Sabine Schneider, Hendrik Streeck, Markus Mueller, Oliver T. Keppler, Thomas Carell
Summary: In this study, chemically stabilized siRNA against SARS-CoV-2 was synthesized and modified with peptides, reducing viral loads and virus-induced cytotoxicity. The siRNA was also able to reduce virus replication and virus-induced apoptosis in 3D mucociliary lung microtissues. The adjustment of siRNA sequence allows rapid adaptation to different variants, and conjugation with receptor ligands via click-chemistry enables the construction of targeted siRNAs for a flexible antiviral defense strategy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Microbiology
Michihito Sasaki, Shinsuke Toba, Yukari Itakura, Herman M. Chambaro, Mai Kishimoto, Koshiro Tabata, Kittiya Intaruck, Kentaro Uemura, Takao Sanaki, Akihiko Sato, William W. Hall, Yasuko Orba, Hirofumi Sawa
Summary: Studies have shown that the loss of the furin cleavage site results in attenuation of SARS-CoV-2 variants in airway tissues of hamsters, with minimal impact on weight loss and inflammatory response. These mutants induce sufficient levels of neutralizing antibodies in hamsters, providing protective immunity against both parental strains and emerging SARS-CoV-2 variants.
Article
Biology
Bruno Burlando, Viviana Mucci, Cherylea J. Browne, Serena Losacco, Iole Indovina, Lucio Marinelli, Franco Blanchini, Giulia Giordano
Summary: Mal de Debarquement Syndrome (MdDS) is a central vestibular disorder characterized by long-lasting postural instability after sea travels or flights. A mathematical model and computational analysis suggest that MdDS may be the result of excessive synaptic plasticity acting on the vestibulo-cerebellar network. Neuroendocrine pathways are proposed as potential therapeutic targets for the disorder.
MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
(2023)
Article
Medicine, General & Internal
Daniele Roberto Giacobbe, Emilio Di Maria, Alberto Stefano Tagliafico, Martina Bavastro, Carlo Simone Trombetta, Cristina Marelli, Gabriele Di Meco, Greta Cattardico, Sara Mora, Alessio Signori, Antonio Vena, Malgorzata Mikulska, Chiara Dentone, Bianca Bruzzone, Bianca Bignotti, Andrea Orsi, Chiara Robba, Lorenzo Ball, Iole Brunetti, Denise Battaglini, Antonio Di Biagio, Maria Pia Sormani, Paolo Pelosi, Mauro Giacomini, Giancarlo Icardi, Matteo Bassetti
Summary: This study validated the prognostic value of the FEN-COVID-19 phenotyping system in hospitalized COVID-19 patients and assessed the reproducibility of phenotypes development. The results showed that patients assigned to phenotype C had a higher mortality rate compared to phenotypes A and B.
ANNALS OF MEDICINE
(2023)
Article
Engineering, Biomedical
Neel Shah, Bing Xue, Ziqi Xu, Hanqing Yang, Eva Marwali, Heidi Dalton, Philip P. R. Payne, Chenyang S. Lu, Ahmed Said
Summary: In this study, several ECMO mortality prediction and severity of illness scores were validated for a large COVID-19 V-V ECMO cohort. The results showed inconsistent discrimination and calibration of these scores, highlighting the need for better clinically applicable decision support tools.
Article
Critical Care Medicine
Alexis Tabah, Niccolo Buetti, Quentin Staiquly, Stephane Ruckly, Murat Akova, Abdullah Tarik Aslan, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Jeffrey Lipman, Ricard Ferrer, Haibo Qiu, Jose-Artur Paiva, Pedro Povoa, Liesbet De Bus, Jan De Waele, Farid Zand, Mohan Gurjar, Adel Alsisi, Khalid Abidi, Hendrik Bracht, Yoshiro Hayashi, Kyeongman Jeon, Muhammed Elhadi, Francois Barbier, Jean-Francois Timsit
Summary: This study investigated hospital-acquired bloodstream infections (HA-BSI) in 2600 adult patients from 333 ICUs in 52 countries. HA-BSI were frequently caused by Gram-negative, carbapenem-resistant, and difficult-to-treat pathogens. Antimicrobial resistance led to delays in adequate antimicrobial therapy, resulting in high mortality rates.
INTENSIVE CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Christiana Kartsonaki, J. Kenneth Baillie, Noelia Garcia Barrio, Joaquin Baruch, Abigail Beane, Lucille Blumberg, Fernando Bozza, Tessa Broadley, Aidan Burrell, Gail Carson, Barbara Wanjiru Citarella, Andrew Dagens, Emmanuelle A. Dankwa, Christl A. Donnelly, Jake Dunning, Loubna Elotmani, Martina Escher, Nataly Farshait, Jean-Christophe Goffard, Bronner P. Goncalves, Matthew Hall, Madiha Hashmi, Benedict Sim Lim Heng, Antonia Ho, Waasila Jassat, Miguel Pedrera Jimenez, Cedric Laouenan, Samantha Lissauer, Ignacio Martin-Loeches, France Mentre, Laura Merson, Ben Morton, Daniel Munblit, Nikita A. Nekliudov, Alistair D. Nichol, Budha Charan Singh Oinam, David Ong, Prasan Kumar Panda, Michele Petrovic, Mark G. Pritchard, Nagarajan Ramakrishnan, Grazielle Viana Ramos, Claire Roger, Oana Sandulescu, Malcolm G. Semple, Pratima Sharma, Louise Sigfrid, Emily C. Somers, Anca Streinu-Cercel, Fabio Taccone, Pavan Kumar Vecham, Bharath Kumar Tirupakuzhi Vijayaraghavan, Jia Wei, Evert-Jan Wils, Xin Ci Wong, Peter Horby, Amanda Rojek, Piero L. Olliaro, Ali Abbas
Summary: This study analyzed demographic features, treatments, and clinical outcomes of hospitalized COVID-19 patients in 52 countries from January 2020 to January 2022. Age and male sex were associated with a higher risk of death. Symptoms, co-morbidities, and treatments were associated with clinical outcomes. This comprehensive international study provides valuable information for prioritizing treatment for COVID-19 patients at higher risk of death.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Critical Care Medicine
Chiara Robba, Denise Battaglini, Raphael Cinotti, Karim Asehnoune, Robert Stevens, Fabio Silvio Taccone, Rafael Badenes, Paolo Pelosi
Summary: The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with acute brain injury during the ICU stay and determine their association with in-hospital mortality. The study found that hypoxemia and mild to moderate hyperoxemia were relatively frequent in these patients and may influence in-hospital mortality. However, the major limitation of the study was the small number of oxygen values collected.
NEUROCRITICAL CARE
(2023)
Article
Physiology
Pietro Ciliberti, Danilo Cardim, Alberto Giardina, Matjaz Groznik, Lorenzo Ball, Martina Giovannini, Denise Battaglini, Erta Beqiri, Basil Matta, Peter Smielewski, Marek Czosnyka, Paolo Pelosi, Chiara Robba
Summary: This study aims to assess the effects of hyperoxygenation and hyperoxemia on cerebral autoregulation in acute brain injured patients. The results suggest that short-term hyperoxygenation does not critically affect cerebral autoregulation.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Denise Battaglini, Brigitta Fazzini, Pedro Leme Silva, Fernanda Ferreira Cruz, Lorenzo Ball, Chiara Robba, Patricia R. M. Rocco, Paolo Pelosi
Summary: Over the last decade, management of acute respiratory distress syndrome (ARDS) has advanced significantly in terms of supportive and pharmacologic therapies. Lung protective mechanical ventilation is crucial for ARDS management, with recommendations including low tidal volume, plateau pressure, and driving pressure. Other therapies such as recruitment maneuvers and prone positioning are considered for severe ARDS cases. Despite extensive research, effective pharmacotherapies for ARDS are yet to be found, but sub-phenotypes of ARDS have shown potential for personalized pharmacologic treatments.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Lucas Rodrigues de Moraes, Chiara Robba, Denise Battaglini, Paolo Pelosi, Patricia R. M. Rocco, Pedro Leme Silva
Summary: Coronavirus disease (COVID-19) is caused by the SARS-CoV-2 virus and can lead to severe respiratory failure requiring mechanical ventilation (MV). Noninvasive respiratory support (NRS), MV, and ECMO are used as treatment strategies. Lung imaging advances have improved understanding of COVID-19 and ventilatory strategies. This review aims to discuss evidence on NRS devices and strategies, personalized MV management based on COVID-19 pathophysiology, and the use of rescue strategies like ECMO in critically ill COVID-19 patients.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Silvia De Rosa, Michele Umbrello, Paolo Pelosi, Denise Battaglini
Summary: Acute critical illnesses can cause significant modifications to vital functions and metabolism. Understanding the nutritional status of patients is crucial for guiding metabolic support. However, assessing nutritional status in these patients remains complex and unresolved. Tools such as computed tomography scans, ultrasound, and bioelectrical impedance analysis can be used to measure lean body mass, but their validation is still needed. A lack of standardized measurement tools at the bedside can impact nutrition outcomes in critical care.
Review
Health Care Sciences & Services
Luca Puce, Carlo Biz, Carlo Trompetto, Lucio Marinelli, Antonio Curra, Luca Cavaggioni, Matteo Formica, Vittorio Vecchi, Maria Chiara Cerchiaro, Khaled Trabelsi, Nicola Luigi Bragazzi, Pietro Ruggieri
Summary: Para-rowing is a rowing format that allows people with disabilities to participate, thanks to adapted equipment and rules. It made its debut at the 2008 Paralympic Games. Rigorous research is needed to support the pursuit of sporting excellence by para-rowers.
Letter
Endocrinology & Metabolism
A. Arecco, S. Ottaviani, M. Boschetti, P. Renzetti, L. Marinelli
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
A. Arecco, S. Ottaviani, M. Boschetti, P. Renzetti, L. Marinelli
Summary: This article aims to review diabetic striatopathy (DS), a rare complication of poorly controlled diabetes mellitus, and raise awareness among physicians. DS mainly affects older Asian women and is characterized by movement disorders, high blood glucose, and abnormal CT and MRI findings. Adequate treatment can improve symptoms of DS.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Leonardo Boccuni, Kilian Abellaneda-Perez, Jesus Martin-Fernandez, David Leno-Colorado, Alba Roca-Ventura, Alba Prats Bisbe, Edgar Antonio Buloz-Osorio, David Bartres-Faz, Nuria Bargallo, Maria Cabello-Toscano, Jose Carlos Pariente, Emma Munoz-Moreno, Carlo Trompetto, Lucio Marinelli, Gloria Villalba-Martinez, Hugues Duffau, Alvaro Pascual-Leone, Josep Maria Tormos Munoz
Summary: Neuromodulation-induced cortical prehabilitation (NICP) is a promising strategy that aims to balance the effective removal of targeted tissue and the preservation of surrounding brain areas in brain tumor surgery. This study investigates the feasibility and potential effectiveness of a non-invasive NICP protocol on neuroplasticity and post-surgical outcomes.
FRONTIERS IN NEUROLOGY
(2023)
Review
Medicine, General & Internal
Lou'i Al-Husinat, Basil Jouryyeh, Ahlam Rawashdeh, Abdelrahman Alenaizat, Mohammad Abushehab, Mohammad Wasfi Amir, Zaid Al Modanat, Denise Battaglini, Gilda Cinnella
Summary: High-flow oxygen therapy (HFOT) is a respiratory support system that delivers high flows of humidified and heated gas to hypoxemic patients, improving arterial blood gases and enhancing patients' comfort. It has wide applications in perioperative medicine, particularly in the intensive care unit and the operating room.
JOURNAL OF CLINICAL MEDICINE
(2023)