Developmental dynamics of RNA translation in the human brain

Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs

(2022) Carlos Sanchez-Priego et al.   Cell Reports

Noncanonical open reading frames encode functional proteins essential for cancer cell survival

(2021) John R. Prensner et al.   NATURE BIOTECHNOLOGY

Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability

(2021) Gabriella L. Boulting et al.   NATURE NEUROSCIENCE

Population-scale tissue transcriptomics maps long non-coding RNAs to complex disease

(2021) Olivia M. de Goede et al.   CELL

Integrated genomic analysis reveals key features of long undecoded transcript isoform-based gene repression

(2021) Amy Tresenrider et al.   MOLECULAR CELL

Evolution of DNA methylation in the human brain

(2021) Hyeonsoo Jeong et al.   Nature Communications

Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

(2021) Christopher J. Playfoot et al.   GENOME RESEARCH

Pervasive functional translation of noncanonical human open reading frames

(2020) Jin Chen et al.   SCIENCE

Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling

(2020) Alban Ordureau et al.   MOLECULAR CELL

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

(2020) Corina Nagy et al.   NATURE NEUROSCIENCE

Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression

(2020) Orna Issler et al.   NEURON

Implications of mRNA translation dysregulation for neurological disorders

(2020) Aya Jishi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

lncRNAKB, a knowledgebase of tissue-specific functional annotation and trait association of long noncoding RNA

(2020) Fayaz Seifuddin et al.   Scientific Data

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

(2020) Priscilla Turelli et al.   Science Advances

Maternal immune activation in mice disrupts proteostasis in the fetal brain

(2020) Brian T. Kalish et al.   NATURE NEUROSCIENCE

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

(2019) Brian Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Translational Landscape of the Human Heart

(2019) Sebastiaan van Heesch et al.   CELL

Proteome-wide signatures of function in highly diverged intrinsically disordered regions

(2019) Taraneh Zarin et al.   eLife

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

Glutamate Dehydrogenase–Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction

(2018) Sharon S Lander et al.   SCHIZOPHRENIA BULLETIN

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

(2018) Ralda Nehme et al.   Cell Reports

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation

(2018) Catherine A. Makarewich et al.   Cell Reports

Dysregulated Translation in Neurodevelopmental Disorders: An Overview of Autism-Risk Genes Involved in Translation

(2018) Yan-Chu Chen et al.   Developmental Neurobiology

Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs

(2018) Joana Carlevaro-Fita et al.   GENOME RESEARCH

The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

(2018) Catherine A Makarewich et al.   eLife

Transcriptome-wide measurement of translation by ribosome profiling

(2017) Nicholas J. McGlincy et al.   METHODS

TimeTree: A Resource for Timelines, Timetrees, and Divergence Times

(2017) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

Regulation of mRNA Translation in Neurons—A Matter of Life and Death

(2017) Mridu Kapur et al.   NEURON

Genome-wide identification and differential analysis of translational initiation

(2017) Peng Zhang et al.   Nature Communications

The DLGAP family: neuronal expression, function and role in brain disorders

(2017) Andreas H. Rasmussen et al.   Molecular Brain

Evolution of Osteocrin as an activity-regulated factor in the primate brain

(2016) Bulent Ataman et al.   NATURE

A human microprotein that interacts with the mRNA decapping complex

(2016) Nadia G D'Lima et al.   Nature Chemical Biology

Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish

(2016) Guo-Liang Chew et al.   Nature Communications

Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders

(2016) Jingrui Xing et al.   Scientific Reports

Translational Tolerance of Mitochondrial Genes to Metabolic Energy Stress Involves TISU and eIF1-eIF4GI Cooperation in Start Codon Selection

(2015) Hadar Sinvani et al.   Cell Metabolism

A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation

(2015) Alexander P. Fields et al.   MOLECULAR CELL

Detecting actively translated open reading frames in ribosome profiling data

(2015) Lorenzo Calviello et al.   NATURE METHODS

The Dfam database of repetitive DNA families

(2015) Robert Hubley et al.   NUCLEIC ACIDS RESEARCH

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

(2015) Zhe Ji et al.   eLife

Dom34 Rescues Ribosomes in 3′ Untranslated Regions

(2014) Nicholas R. Guydosh et al.   CELL

A Human Short Open Reading Frame (sORF)-encoded Polypeptide That Stimulates DNA End Joining

(2014) Sarah A. Slavoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs

(2014) R. Johnson et al.   RNA

Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq

(2014) Julie L Aspden et al.   eLife

Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

(2013) Aurélie Kapusta et al.   PLoS Genetics

Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

(2012) Francesca Frigerio et al.   JOURNAL OF NEUROCHEMISTRY

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

High-Resolution View of the Yeast Meiotic Program Revealed by Ribosome Profiling

(2011) G. A. Brar et al.   SCIENCE

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

The Autistic Neuron: Troubled Translation?

(2008) Raymond J. Kelleher et al.   CELL