Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Massively parallel genomic perturbations with multi-target CRISPR interrogates Cas9 activity and DNA repair at endogenous sites
Authors
Keywords
-
Journal
NATURE CELL BIOLOGY
Volume 24, Issue 9, Pages 1433-1444
Publisher
Springer Science and Business Media LLC
Online
2022-09-06
DOI
10.1038/s41556-022-00975-z
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cas9 deactivation with photocleavable guide RNAs
- (2021) Roger S. Zou et al. MOLECULAR CELL
- Loop extrusion as a mechanism for formation of DNA damage repair foci
- (2021) Coline Arnould et al. NATURE
- Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication
- (2021) Vinay Tripuraneni et al. GENOME RESEARCH
- Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
- (2021) Ruben Schep et al. MOLECULAR CELL
- Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
- (2021) Peter J. Chen et al. CELL
- Mapping the genetic landscape of DNA double-strand break repair
- (2021) Jeffrey A. Hussmann et al. CELL
- Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
- (2020) Ivan E. Ivanov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Histone Chaperone FACT Induces Cas9 Multi-turnover Behavior and Modifies Genome Manipulation in Human Cells
- (2020) Alan S. Wang et al. MOLECULAR CELL
- CHANGE-seq reveals genetic and epigenetic effects on CRISPR–Cas9 genome-wide activity
- (2020) Cicera R. Lazzarotto et al. NATURE BIOTECHNOLOGY
- Very fast CRISPR on demand
- (2020) Yang Liu et al. SCIENCE
- DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
- (2020) Patrick L. Collins et al. Nature Communications
- A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks
- (2019) Thomas Clouaire et al. TRENDS IN GENETICS
- Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair
- (2019) Wei Chen et al. NUCLEIC ACIDS RESEARCH
- Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
- (2019) Fabio Pessina et al. NATURE CELL BIOLOGY
- Search-and-replace genome editing without double-strand breaks or donor DNA
- (2019) Andrew V. Anzalone et al. NATURE
- Advances in genome editing through control of DNA repair pathways
- (2019) Charles D. Yeh et al. NATURE CELL BIOLOGY
- Protein Dynamics in Complex DNA Lesions
- (2018) Radoslav Aleksandrov et al. MOLECULAR CELL
- Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks
- (2018) Ryan Clarke et al. MOLECULAR CELL
- Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks
- (2018) Eva K. Brinkman et al. MOLECULAR CELL
- CRISPR–Cas9 genome editing in human cells occurs via the Fanconi anemia pathway
- (2018) Chris D. Richardson et al. NATURE GENETICS
- Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures
- (2018) Thomas Clouaire et al. MOLECULAR CELL
- A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression
- (2018) Jeroen van den Berg et al. NUCLEIC ACIDS RESEARCH
- Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo
- (2018) Robert M. Yarrington et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CRISPR-Cas guides the future of genetic engineering
- (2018) Gavin J. Knott et al. SCIENCE
- Developmental barcoding of whole mouse via homing CRISPR
- (2018) Reza Kalhor et al. SCIENCE
- Predictable and precise template-free CRISPR editing of pathogenic variants
- (2018) Max W. Shen et al. NATURE
- Predicting the mutations generated by repair of Cas9-induced double-strand breaks
- (2018) Felicity Allen et al. NATURE BIOTECHNOLOGY
- The influence of eukaryotic chromatin state on CRISPR–Cas9 editing efficiencies
- (2018) Sebald AN Verkuijl et al. CURRENT OPINION IN BIOTECHNOLOGY
- An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
- (2017) M Ryan Corces et al. NATURE METHODS
- Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics
- (2017) John C Rose et al. NATURE METHODS
- Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy
- (2017) Mikihiro Shibata et al. Nature Communications
- BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks
- (2017) Winston X. Yan et al. Nature Communications
- DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks
- (2016) Megan van Overbeek et al. MOLECULAR CELL
- Rapidly evolving homing CRISPR barcodes
- (2016) Reza Kalhor et al. NATURE METHODS
- Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
- (2016) Digvijay Singh et al. Nature Communications
- Nucleosomes impede Cas9 access to DNA in vivo and in vitro
- (2016) Max A Horlbeck et al. eLife
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Single-cell chromatin accessibility reveals principles of regulatory variation
- (2015) Jason D. Buenrostro et al. NATURE
- Conformational control of DNA target cleavage by CRISPR–Cas9
- (2015) Samuel H. Sternberg et al. NATURE
- Dynamics of CRISPR-Cas9 genome interrogation in living cells
- (2015) Spencer C. Knight et al. SCIENCE
- Nucleosome Positioning, Nucleosome Spacing and the Nucleosome Code
- (2014) David J. Clark JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
- (2014) Xuebing Wu et al. NATURE BIOTECHNOLOGY
- Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
- (2014) Cem Kuscu et al. NATURE BIOTECHNOLOGY
- GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
- (2014) Shengdar Q Tsai et al. NATURE BIOTECHNOLOGY
- Chromatin Remodeling at DNA Double-Strand Breaks
- (2013) Brendan D. Price et al. CELL
- Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
- (2013) Jason D Buenrostro et al. NATURE METHODS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures
- (2013) Catherine Naughton et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcription-dependent dynamic supercoiling is a short-range genomic force
- (2013) Fedor Kouzine et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Alu elements: know the SINEs
- (2011) Prescott Deininger GENOME BIOLOGY
- Model-based Analysis of ChIP-Seq (MACS)
- (2008) Yong Zhang et al. GENOME BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now