CD24-gold nanocomposite as promising and sensitive biomarker for cancer stem cells in salivary gland tumors

Cancer stem cells are highly tumorigenic cells in the majority of the tumor that are responsible for the initiation, rapid growth, invasion, metastasis, and therapeutic resistance associated with various human cancers. The aim of this project is to assess a diagnostic and prognostic biomarker for the detection of cancer stem cells in salivary gland tumors using gold nanoparticles that are synthesized and conjugated to CD24 primer to form a CD24-Gold Nanocomposite. Sixty cases were included (29 pleomorphic adenoma, 19 carcinoma ex pleomorphic adenoma, and 12 normal controls). Alterations in biomarker expression between studied groups were analyzed and correlated with clinicopathological characteristics using Fisher's exact and Chi-square tests. ROC and Kaplan-Meier curves were used to validate diagnostic and prognostic values, respectively. This study confirms that CD24-Gold Nanocomposite served as a promising and highly sensitive biomarker in salivary gland tumor diagnosis and prognosis prediction. (c) 2022 Elsevier Inc. All rights reserved.

Automated summary

This study aimed to evaluate a diagnostic and prognostic biomarker for the detection of cancer stem cells in salivary gland tumors. Cancer stem cells play a crucial role in the initiation, rapid growth, invasion, metastasis, and therapeutic resistance of tumors. The study analyzed and compared 60 cases using synthesized gold nanoparticles conjugated to CD24 primer to form a CD24-Gold Nanocomposite. The results confirmed the promising and highly sensitive diagnostic and prognostic value of CD24-Gold Nanocomposite in salivary gland tumor diagnosis and prognosis prediction.