First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor

Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption

(2022) Renshuai Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1

(2021) Renshuai Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells

(2021) Yunying Huang et al.   Nutrients

Small Molecules with Big Impacts on Cardiovascular Diseases

(2020) Fatemeh Mirzadeh Azad et al.   BIOCHEMICAL GENETICS

Lipid-Lowering Effects and Intestinal Transport of Polyphenols Extract from Digested-Buckwheat in Caco-2/HepG2 Co-culture Models

(2020) Yijun Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion

(2020) Xin Wang et al.   Cells

Three Musketeers for Lowering Cholesterol: Statins, Ezetimibe and Evolocumab

(2020) Qian Xu et al.   CURRENT MEDICINAL CHEMISTRY

Molecular insight into the mechanism of lipid regulating effect of Alisma orientalis based on ACAT

(2020) Fei Xu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Parthenolide inhibits the tumor characteristics of renal cell carcinoma

(2020) Dandan Liu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cyanidin-3-rutinoside acts as a natural inhibitor of intestinal lipid digestion and absorption

(2019) Thavaree Thilavech et al.   BMC Complementary and Alternative Medicine

Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation

(2019) Chae Young Kim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Transport of cowpea bean derived peptides and their modulator effects on mRNA expression of cholesterol-related genes in Caco-2 and HepG2 cells

(2018) Marcelo Rodrigues Marques et al.   FOOD RESEARCH INTERNATIONAL

Insulin increases cholesterol uptake, lipid droplet content, and apolipoprotein B secretion in CaCo‐2 cells by upregulating SR‐BI via a PI3K, AKT, and mTOR‐dependent pathway

(2018) Marcela Fuentes et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer

(2016) Sridharan Jeyamohan et al.   BIOTECHNOLOGY LETTERS

Synergistic antitumor effect of 5-fluorouracil in combination with parthenolide in human colorectal cancer

(2013) Se-Lim Kim et al.   CANCER LETTERS

Black rice and anthocyanins induce inhibition of cholesterol absorption in vitro

(2013) Shu-Long Yao et al.   Food & Function

Parthenolide induces caspase-independent and AIF-mediated cell death in human osteosarcoma and melanoma cells

(2012) Antonella D'Anneo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels

(2012) Clapton S. Dias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The role of peroxidases in the pathogenesis of atherosclerosis

(2011) Jong-Gil Park et al.   BMB Reports

Parthenolide, a Sesquiterpene Lactone, Expresses Multiple Anti-cancer and Anti-inflammatory Activities

(2011) Vivek Bhakta Mathema et al.   INFLAMMATION

The N-terminal Domain of NPC1L1 Protein Binds Cholesterol and Plays Essential Roles in Cholesterol Uptake

(2011) Jin-Hui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A NADPH Oxidase–Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells

(2010) Yulan Sun et al.   CANCER RESEARCH

Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro

(2010) Jun-Wei Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1

(2008) Liang Ge et al.   Cell Metabolism