Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption

One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1

(2021) Renshuai Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Modeling of Ezetimibe Analogues

(2021) Mateo M. Salgado et al.   MOLECULES

Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake

(2021) Miaoqing Hu et al.   Science Advances

Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption

(2021) Tao Long et al.   Science Advances

Three Musketeers for Lowering Cholesterol: Statins, Ezetimibe and Evolocumab

(2020) Qian Xu et al.   CURRENT MEDICINAL CHEMISTRY

Recent Updates on Obesity Treatments: Available Drugs and Future Directions

(2020) Nathalia R.V. Dragano et al.   NEUROSCIENCE

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

(2020) Ching-Shin Huang et al.   Science Advances

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

(2019) Renshuai Zhang et al.   DRUG DELIVERY

The Effect of Polyphenols on Hypercholesterolemia through Inhibiting the Transport and Expression of Niemann–Pick C1-Like 1

(2019) Shoko Kobayashi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Niemann-Pick C1-like protein 1 by ezetimibe reduces uptake of deuterium-labeled vitamin D in mice

(2019) Mikis Kiourtzidis et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo

(2018) Suwen Liu et al.   FOOD RESEARCH INTERNATIONAL

Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols

(2018) Lijun Wang et al.   PHYTOMEDICINE

Bean peptides have higher in silico binding affinities than ezetimibe for the N-terminal domain of cholesterol receptor Niemann-Pick C1 Like-1

(2017) Luis M. Real Hernandez et al.   PEPTIDES

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require endocytosis

(2016) Tory A. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid bilayer thickness determines cholesterol's location in model membranes

(2016) Drew Marquardt et al.   Soft Matter

Orlistat limits cholesterol intestinal absorption by Niemann-pick C1-like 1 (NPC1L1) inhibition

(2015) Saeed Alqahtani et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe

(2015) Tomohiro Chiba et al.   PLoS One

Structure–activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout

(2014) Fumika Karaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Virtual Screening for Cholesterol Absorption Inhibitors

(2014) Lidan Sun et al.   Medicinal Chemistry

Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann–Pick C1-Like 1 in Caco-2 Cells and Rats

(2014) Mari Nekohashi et al.   PLoS One

Structure–activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect

(2013) Fumika Karaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of Oxysterol-Derived Pharmacological Chaperones for NPC1: Implication for the Existence of Second Sterol-Binding Site

(2013) Kenji Ohgane et al.   CHEMISTRY & BIOLOGY

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

(2013) Pei-Shan Li et al.   NATURE MEDICINE

Dietary Patterns in Asian Indians in the United States: An Analysis of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Study

(2013) Meghana D. Gadgil et al.   Journal of the Academy of Nutrition and Dietetics

Niemann–Pick C1-Like 1 and cholesterol uptake

(2012) Li-Juan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A pulse-based diet is effective for reducing total and LDL-cholesterol in older adults

(2012) Saman Abeysekara et al.   BRITISH JOURNAL OF NUTRITION

Blueberry anthocyanins at doses of 0.5 and 1 % lowered plasma cholesterol by increasing fecal excretion of acidic and neutral sterols in hamsters fed a cholesterol-enriched diet

(2012) Yintong Liang et al.   EUROPEAN JOURNAL OF NUTRITION

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression

(2012) Dan Feng et al.   Lipids in Health and Disease

Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes

(2012) Bolin Qin et al.   NUTRITION

Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport

(2011) Lin Jia et al.   Annual Review of Physiology

The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation

(2011) Hyock Joo Kwon et al.   PLoS One

Spiroimidazolidinone NPC1L1 inhibitors. Part 2: Structure–activity studies and in vivo efficacy

(2010) Kobporn L. Howell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake

(2010) L. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Niemann–Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter

(2009) Harry R. Davis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening

(2009) Daniel R. McMasters et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand

(2009) Joseph P. Simeone et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Does higher usage of low-cost statins correlate with a poorer achievement in cholesterol quality markers for secondary prevention?

(2009) James Hickman   BRITISH JOURNAL OF GENERAL PRACTICE

Update on patented cholesterol absorption inhibitors

(2009) M T Chhabria et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1

(2008) Liang Ge et al.   Cell Metabolism

Ezetimibe, a Selective Inhibitor of the Transport of Cholesterol

(2008) Shin-ichiro Miura et al.   INTERNAL MEDICINE

Chemical and Biological Folding Contribute to Temperature-Sensitive ΔF508 CFTR Trafficking

(2008) Xiaodong Wang et al.   TRAFFIC

Substituted oxazolidinones as novel NPC1L1 ligands for the inhibition of cholesterol absorption

(2007) Jeffrey A. Pfefferkorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS