The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation

Rethinking Remdesivir: Synthesis, Antiviral Activity, and Pharmacokinetics of Oral Lipid Prodrugs

(2021) Robert T. Schooley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, synthesis and evaluation of 2′-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents

(2021) Linjie Yan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-HIV-active Nucleoside Triphosphate Prodrugs

(2020) Xiao Jia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2′-deoxy-2′-fluoro-2′-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase

(2020) Uma S. Singh et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

A library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19

(2020) Steffen Jockusch et al.   ANTIVIRAL RESEARCH

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19

(2020) Minchen Chien et al.   JOURNAL OF PROTEOME RESEARCH

Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic

(2020) Rodrigo Jácome et al.   Scientific Reports

Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity

(2020) Olga V. Andreeva et al.   MOLECULAR DIVERSITY

A practical synthesis of nucleoside 5′-diphosphates from nucleoside 5′-H-phosphonate monoesters

(2020) Marta Rachwalak et al.   SYNTHETIC COMMUNICATIONS

Nucleoside analogues for the treatment of coronavirus infections

(2019) Andrea J Pruijssers et al.   Current Opinion in Virology

Synthesis of novel 1,2,3-triazolyl nucleoside analogues bearing uracil, 6-methyluracil, 3,6-dimethyluracil, thymine, and quinazoline-2,4-dione moieties

(2019) Olga V. Andreeva et al.   TETRAHEDRON LETTERS

Selected nucleos(t)ide-based prescribed drugs and their multi-target activity

(2019) Gabriela Pastuch-Gawołek et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold

(2018) Katherine L. Seley-Radtke et al.   ANTIVIRAL RESEARCH

Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase

(2018) Gang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evidence for Novel Action at the Cell-Binding Site of Human Angiogenin Revealed by Heteronuclear NMR Spectroscopy, in silico and in vivo Studies

(2018) Demetra S. M. Chatzileontiadou et al.   ChemMedChem

Synthesis and Antiviral Evaluation of TriPPPro-AbacavirTP, TriPPPro-CarbovirTP and their 1',2'-cis-disubstituted Analogues

(2018) Simon Weising et al.   ChemMedChem

2′-Fluoro-6′-methylene carbocyclic adenosine and its phosphoramidate prodrug: A novel anti-HBV agent, active against drug-resistant HBV mutants

(2018) Uma S. Singh et al.   MEDICINAL RESEARCH REVIEWS

The ProTide Prodrug Technology: From the Concept to the Clinic

(2017) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues

(2016) Tristan Gollnest et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit

(2016) Satoshi Fudo et al.   BIOCHEMISTRY

Recent Trends in Nucleotide Synthesis

(2016) Béatrice Roy et al.   CHEMICAL REVIEWS

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

5-(4-alkyl-1,2,3-triazol-1-yl)methyl derivatives of 2′-deoxyuridine as inhibitors of viral and bacterial growth

(2016) L. A. Alexandrova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin

(2015) Demetra S.M. Chatzileontiadou et al.   BIOORGANIC CHEMISTRY

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

(2015) Tristan Gollnest et al.   Nature Communications

Synthesis of an Apionucleoside Family and Discovery of a Prodrug with Anti-HIV Activity

(2014) Kiran S. Toti et al.   JOURNAL OF ORGANIC CHEMISTRY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Stereoselective Synthesis of α- and β-Glycofuranosyl Amides by Traceless Ligation of Glycofuranosyl Azides

(2012) Filippo Nisic et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates

(2011) Junxing Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition

(2011) Pedro Cano-Soldado et al.   MEDICINAL RESEARCH REVIEWS

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus

(2010) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-HIV therapy with AZT prodrugs: AZT phosphonate derivatives, current state and prospects

(2010) Anastasiya Khandazhinskaya et al.   Expert Opinion on Drug Metabolism & Toxicology

Structures of influenza A proteins and insights into antiviral drug targets

(2010) Kalyan Das et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells

(2009) Youcef Mehellou et al.   ChemMedChem

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

One-Pot Synthesis of Nucleoside 5′-Triphosphates from Nucleoside 5′-H-Phosphonates

(2008) Qi Sun et al.   ORGANIC LETTERS