Crucial Role of RLIP76 in Promoting Glycolysis and Tumorigenesis by Stabilization of HIF-1α in Glioma Cells Under Hypoxia

Hypoxia-related long noncoding RNAs are associated with varicocele-related male infertility

(2020) Nafiseh Sanei Ata-abadi et al.   PLoS One

Systemic chemotherapy promotes HIF‐1α‐mediated glycolysis and IL‐17F pathways in cutaneous T‐cell lymphoma

(2020) Bo Wang et al.   EXPERIMENTAL DERMATOLOGY

Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma

(2020) Xiaojun Ren et al.   Molecular Medicine Reports

Hypoxia-Inducible Factor Activators in Renal Anemia: Current Clinical Experience

(2019) Neil S. Sanghani et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Increased RLIP76 expression in IDH1 wild‑type glioblastoma multiforme is associated with worse prognosis

(2019) Qi Wang et al.   ONCOLOGY REPORTS

Hypoxia induces core-to-edge transition of progressive tumoral cells: A critical review on differential yet corroborative roles for HIF-1α and HIF-2α

(2019) Keywan Mortezaee   LIFE SCIENCES

Isocitrate dehydrogenase 1–mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress

(2018) Krissie Lenting et al.   FASEB JOURNAL

ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells

(2018) Yunjie Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

2'-Hydroxyflavanone effectively targets RLIP76-mediated drug transport and regulates critical signaling networks in breast cancer

(2018) Lokesh Dalasanur Nagaprashantha et al.   Oncotarget

Role of HIF-1 in Cancer Progression: Novel Insights. A Review

(2018) Aldo Pezzuto et al.   CURRENT MOLECULAR MEDICINE

Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis

(2018) Rongli Sun et al.   TOXICOLOGY IN VITRO

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line

(2018) Haci Ahmet Deveci et al.   BIOMEDICINE & PHARMACOTHERAPY

A glycolysis-based ten-gene signature correlates with the clinical outcome, molecular subtype and IDH1 mutation in glioblastoma

(2017) Cong Chen et al.   Journal of Genetics and Genomics

RLIP76 Inhibition: A Promising Developmental Therapy for Neuroblastoma

(2017) Sharad S. Singhal et al.   PHARMACEUTICAL RESEARCH

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

(2017) Luisa Iommarini et al.   Frontiers in Oncology

Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis

(2016) Yunho Kim et al.   Nature Communications

miR-495 Mediates Metabolic Shift in Glioma Cells via Targeting Glut1

(2015) Sheng Nie et al.   JOURNAL OF CRANIOFACIAL SURGERY

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling

(2014) Helen R. Mott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells

(2014) Seunghyung Lee et al.   FASEB JOURNAL

MDM2 Regulates Hypoxic Hypoxia-inducible Factor 1α Stability in an E3 Ligase, Proteasome, and PTEN-Phosphatidylinositol 3-Kinase-AKT-dependent Manner

(2014) Shweta Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

(2014) Ming Yan et al.   JOURNAL OF CLINICAL INVESTIGATION

RLIP76 is overexpressed in human glioblastomas and is required for proliferation, tumorigenesis and suppression of apoptosis

(2013) Qi Wang et al.   CARCINOGENESIS

Knockdown of RLIP76 expression by RNA interference inhibits invasion, induces cell cycle arrest, and increases chemosensitivity to the anticancer drug temozolomide in glioma cells

(2013) Qi Wang et al.   JOURNAL OF NEURO-ONCOLOGY

RLIP76 Regulates PI3K/Akt Signaling and Chemo-Radiotherapy Resistance in Pancreatic Cancer

(2012) Kathryn Leake et al.   PLoS One

Astrocyte-elevated gene-1 (AEG-1) induction by hypoxia and glucose deprivation in glioblastoma

(2011) Evan Noch et al.   CANCER BIOLOGY & THERAPY

Interaction of HIF and USF Signaling Pathways in Human Genes Flanked by Hypoxia-Response Elements and E-box Palindromes

(2011) J. Hu et al.   MOLECULAR CANCER RESEARCH

Diminished drug transport and augmented radiation sensitivity caused by loss of RLIP76

(2008) Sharad S. Singhal et al.   FEBS LETTERS