The pausing zone and control of RNA polymerase II elongation by Spt5: Implications for the pause-release model
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The pausing zone and control of RNA polymerase II elongation by Spt5: Implications for the pause-release model
Authors
Keywords
-
Journal
MOLECULAR CELL
Volume 82, Issue 19, Pages 3632-3645.e4
Publisher
Elsevier BV
Online
2022-10-07
DOI
10.1016/j.molcel.2022.09.001
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Heat shock induces premature transcript termination and reconfigures the human transcriptome
- (2022) Simona Cugusi et al. MOLECULAR CELL
- Integrator is a genome-wide attenuator of non-productive transcription
- (2021) Søren Lykke-Andersen et al. MOLECULAR CELL
- The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
- (2021) Stephin J. Vervoort et al. CELL
- Conserved DNA sequence features underlie pervasive RNA polymerase pausing
- (2021) Martyna Gajos et al. NUCLEIC ACIDS RESEARCH
- SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape
- (2021) Shibin Hu et al. MOLECULAR CELL
- STL-seq reveals pause-release and termination kinetics for promoter-proximal paused RNA polymerase II transcripts
- (2021) Joshua T. Zimmer et al. MOLECULAR CELL
- Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
- (2021) Ashwin Narain et al. MOLECULAR CELL
- SPT5 stabilization of promoter-proximal RNA polymerase II
- (2021) Yuki Aoi et al. MOLECULAR CELL
- Structural basis of Integrator-mediated transcription regulation
- (2021) Isaac Fianu et al. SCIENCE
- NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release
- (2020) Yuki Aoi et al. MOLECULAR CELL
- Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
- (2020) Seychelle M. Vos et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination
- (2020) Kai-Lieh Huang et al. MOLECULAR CELL
- Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
- (2020) Behnam Nabet et al. Nature Communications
- Causes and consequences of RNA polymerase II stalling during transcript elongation
- (2020) Melvin Noe Gonzalez et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription
- (2020) Grace A. Rosen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DEBrowser: interactive differential expression analysis and visualization tool for count data
- (2019) Alper Kucukural et al. BMC GENOMICS
- MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation
- (2019) Apoorva Baluapuri et al. MOLECULAR CELL
- Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
- (2019) Leighton Core et al. GENES & DEVELOPMENT
- The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes
- (2019) Nathan D. Elrod et al. MOLECULAR CELL
- Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism
- (2019) Michael A. Cortazar et al. MOLECULAR CELL
- Regulation of RNA polymerase II processivity by Spt5 is restricted to a narrow window during elongation
- (2018) Johanna Fitz et al. EMBO JOURNAL
- Born to run: control of transcription elongation by RNA polymerase II
- (2018) Fei Xavier Chen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II
- (2018) Barbara Steurer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic turnover of paused Pol II complexes at human promoters
- (2018) Benjamin Erickson et al. GENES & DEVELOPMENT
- A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II
- (2018) Pabitra K. Parua et al. NATURE
- Structure of paused transcription complex Pol II–DSIF–NELF
- (2018) Seychelle M. Vos et al. NATURE
- Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
- (2018) Seychelle M. Vos et al. NATURE
- Structure and nucleic acid binding properties of KOW domains 4 and 6–7 of human transcription elongation factor DSIF
- (2018) Philipp K. Zuber et al. Scientific Reports
- Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5′ Pause Release, Termination, and Transcription Elongation Rate
- (2018) Ryan M. Sheridan et al. MOLECULAR CELL
- UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
- (2017) Tom Smith et al. GENOME RESEARCH
- Identification of Regions in the Spt5 Subunit of DRB Sensitivity-inducing Factor (DSIF) That Are Involved in Promoter-proximal Pausing
- (2017) Yijun Qiu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide Analysis of RNA Polymerase II Termination at Protein-Coding Genes
- (2017) Carlo Baejen et al. MOLECULAR CELL
- Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation
- (2017) Ameet Shetty et al. MOLECULAR CELL
- Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp
- (2017) Carrie Bernecky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome
- (2017) John B. Crickard et al. NUCLEIC ACIDS RESEARCH
- Application of a Schizosaccharomyces pombe Edc1-fused Dcp1–Dcp2 decapping enzyme for transcription start site mapping
- (2017) David R. Paquette et al. RNA
- Structure of a transcribing RNA polymerase II–DSIF complex reveals a multidentate DNA–RNA clamp
- (2017) Carrie Bernecky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Selectable one-step PCR-mediated integration of a degron for rapid depletion of endogenous human proteins
- (2016) Ryan M. Sheridan et al. BIOTECHNIQUES
- Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown
- (2016) Mihaela Pertea et al. Nature Protocols
- Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing
- (2015) Takayuki Nojima et al. CELL
- Getting up to speed with transcription elongation by RNA polymerase II
- (2015) Iris Jonkers et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II–transcribed genes
- (2015) Clélia Laitem et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways
- (2015) Xiuli Liu et al. TRENDS IN BIOCHEMICAL SCIENCES
- CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II–transcribed genes
- (2015) Clélia Laitem et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress
- (2014) Marco Saponaro et al. CELL
- Nucleosomes Are Context-Specific, H2A.Z-Modulated Barriers to RNA Polymerase
- (2014) Christopher M. Weber et al. MOLECULAR CELL
- Coupling mRNA processing with transcription in time and space
- (2014) David L. Bentley NATURE REVIEWS GENETICS
- Interactions between RNA polymerase and the "core recognition element" counteract pausing
- (2014) I. O. Vvedenskaya et al. SCIENCE
- Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
- (2014) Iris Jonkers et al. eLife
- NusG-Spt5 Proteins—Universal Tools for Transcription Modification and Communication
- (2013) Sushil Kumar Tomar et al. CHEMICAL REVIEWS
- GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination
- (2013) P. A. Ginno et al. GENOME RESEARCH
- Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin
- (2013) A. D. Wier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond
- (2012) Yuki Yamaguchi et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- The Spt5 C-Terminal Region Recruits Yeast 3' RNA Cleavage Factor I
- (2012) A. Mayer et al. MOLECULAR AND CELLULAR BIOLOGY
- mRNA Decapping Factors and the Exonuclease Xrn2 Function in Widespread Premature Termination of RNA Polymerase II Transcription
- (2012) Kris Brannan et al. MOLECULAR CELL
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Nascent RNA structure modulates the transcriptional dynamics of RNA polymerases
- (2012) B. Zamft et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential GC Content between Exons and Introns Establishes Distinct Strategies of Splice-Site Recognition
- (2012) Maayan Amit et al. Cell Reports
- Nascent transcript sequencing visualizes transcription at nucleotide resolution
- (2011) L. Stirling Churchman et al. NATURE
- Counting absolute numbers of molecules using unique molecular identifiers
- (2011) Teemu Kivioja et al. NATURE METHODS
- c-Myc Regulates Transcriptional Pause Release
- (2010) Peter B. Rahl et al. CELL
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Repression of RNA Polymerase II Elongation In Vivo Is Critically Dependent on the C-Terminus of Spt5
- (2009) Hui Chen et al. PLoS One
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now