Nuanced Interactions between AKAP79 and STIM1 with Orai1 Ca 2+ Channels at Endoplasmic Reticulum-Plasma Membrane Junctions Sustain NFAT Activation

The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry

(2021) Pulak Kar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics

(2020) Guoxia Liu et al.   NATURE

STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca2+entry with NFAT1 activation

(2020) Ga-Yeon Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Store-Operated Ca2+ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets

(2020) Daniel Bakowski et al.   Annual Review of Pharmacology and Toxicology

AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+ channels.

(2019) Jonathan G. Murphy et al.   MOLECULAR BIOLOGY OF THE CELL

Whole-Cell cAMP and PKA Activity are Epiphenomena, Nanodomain Signaling Matters

(2019) Donald M. Bers et al.   PHYSIOLOGY

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

(2019) Xuexin Zhang et al.   Nature Communications

Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression

(2019) Yi-Chun Yeh et al.   HUMAN MOLECULAR GENETICS

Local protein kinase A action proceeds through intact holoenzymes

(2017) F. Donelson Smith et al.   SCIENCE

Molecular basis of AKAP79 regulation by calmodulin

(2017) Neha Patel et al.   Nature Communications

Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca 2+ Signals

(2016) Pulak Kar et al.   MOLECULAR CELL

Molecular Biophysics of Orai Store-Operated Ca2+ Channels

(2015) Anna Amcheslavsky et al.   BIOPHYSICAL JOURNAL

A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca2+ influx levels

(2015) R. Hodeify et al.   JOURNAL OF CELL SCIENCE

Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

(2015) Pulak Kar et al.   MOLECULAR CELL

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1

(2014) Pulak Kar et al.   CURRENT BIOLOGY

Store-Operated CRAC Channels Regulate Gene Expression and Proliferation in Neural Progenitor Cells

(2014) A. Somasundaram et al.   JOURNAL OF NEUROSCIENCE

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

AKAP signaling complexes: pointing towards the next generation of therapeutic targets?

(2013) Jessica L. Esseltine et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Simplified Equation to Extract Diffusion Coefficients from Confocal FRAP Data

(2012) Minchul Kang et al.   TRAFFIC

Palmitoylation Targets AKAP79 Protein to Lipid Rafts and Promotes Its Regulation of Calcium-sensitive Adenylyl Cyclase Type 8

(2011) Ilse Delint-Ramirez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex

(2011) M. G. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

(2011) S. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+Entry (SOCE)

(2008) Biswaranjan Pani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ca2+microdomains near plasma membrane Ca2+channels: impact on cell function

(2008) Anant B. Parekh   JOURNAL OF PHYSIOLOGY-LONDON