Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer
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Title
Comparative Proteomic Analysis Identifies Key Metabolic Regulators of Gemcitabine Resistance in Pancreatic Cancer
Authors
Keywords
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Journal
MOLECULAR & CELLULAR PROTEOMICS
Volume 21, Issue 10, Pages 100409
Publisher
Elsevier BV
Online
2022-09-07
DOI
10.1016/j.mcpro.2022.100409
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Note: Only part of the references are listed.- Cancer Statistics, 2021
- (2021) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Synergistic pharmacodynamic effects of gemcitabine and fibroblast growth factor receptor inhibitors on pancreatic cancer cell cycle kinetics and proliferation
- (2021) Qingxiang Lin et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Estimated Projection of US Cancer Incidence and Death to 2040
- (2021) Lola Rahib et al. JAMA Network Open
- OSpaad: An online tool to perform survival analysis by integrating gene expression profiling and long‐term follow‐up data of 1319 pancreatic carcinoma patients
- (2020) Guosen Zhang et al. MOLECULAR CARCINOGENESIS
- Gemcitabine‐induced epithelial‐mesenchymal transition‐like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal‐like phenotype
- (2019) Mehdi El Amrani et al. MOLECULAR CARCINOGENESIS
- Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma
- (2019) Rebecca L. Porter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2′,2′-difluorodeoxyuridine and their nucleotides
- (2018) Ellen J. B. Derissen et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
- (2018) Jianfang Liu et al. CELL
- Targeting ALDH2 with disulfiram/copper reverses the resistance of cancer cells to microtubule inhibitors
- (2018) Nan-nan Wang et al. EXPERIMENTAL CELL RESEARCH
- Copper efflux transporters ATP7A and ATP7B: Novel biomarkers for platinum drug resistance and targets for therapy
- (2018) Yue-Qin Li et al. IUBMB LIFE
- Temporal Effects of Combined Birinapant and Paclitaxel on Pancreatic Cancer Cells InvestigatedviaLarge-Scale, Ion-Current-Based Quantitative Proteomics (IonStar)
- (2018) Xue Wang et al. MOLECULAR & CELLULAR PROTEOMICS
- IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts
- (2018) Xiaomeng Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells
- (2018) Xu Zhu et al. Frontiers in Pharmacology
- Surfactant Cocktail-Aided Extraction/Precipitation/On-Pellet Digestion Strategy Enables Efficient and Reproducible Sample Preparation for Large-Scale Quantitative Proteomics
- (2018) Shichen Shen et al. ANALYTICAL CHEMISTRY
- FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer
- (2018) Thierry Conroy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
- (2017) E Hessmann et al. GUT
- An IonStar Experimental Strategy for MS1 Ion Current-Based Quantification Using Ultrahigh-Field Orbitrap: Reproducible, In-Depth, and Accurate Protein Measurement in Large Cohorts
- (2017) Xiaomeng Shen et al. JOURNAL OF PROTEOME RESEARCH
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- (2017) Tsukasa Shibue et al. Nature Reviews Clinical Oncology
- Gemcitabine Enhances Kras-MEK–Induced Matrix Metalloproteinase-10 Expression Via Histone Acetylation in Gemcitabine-Resistant Pancreatic Tumor-initiating Cells
- (2017) Kazuya Shimizu et al. PANCREAS
- Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
- (2017) Leore T. Geller et al. SCIENCE
- Enhanced Stim1 expression is associated with acquired chemo-resistance of cisplatin in osteosarcoma cells
- (2017) Xilong Sun et al. Human Cell
- S100A4 in cancer progression and metastasis: A systematic review
- (2017) Fei Fei et al. Oncotarget
- Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer
- (2017) Ru Chen et al. Scientific Reports
- Pancreatic Cancer Chemoresistance to Gemcitabine
- (2017) Manoj Amrutkar et al. Cancers
- TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells
- (2016) Jeffrey Q. Nguyen et al. CANCER BIOLOGY & THERAPY
- ATP7B expression confers multidrug resistance through drug sequestration
- (2016) F M Moinuddin et al. Oncotarget
- The role of copper transporter ATP7A in platinum-resistance of esophageal squamous cell cancer (ESCC)
- (2016) Zhuang-hua Li et al. Journal of Cancer
- The Genotype-Tissue Expression (GTEx) Project
- (2015) Latarsha J. Carithers et al. BIOPRESERVATION AND BIOBANKING
- Aldehyde dehydrogenases and cancer stem cells
- (2015) Xia Xu et al. CANCER LETTERS
- Gemcitabine resistance in pancreatic ductal adenocarcinoma
- (2015) Yoav Binenbaum et al. DRUG RESISTANCE UPDATES
- Experimental Null Method to Guide the Development of Technical Procedures and to Control False-Positive Discovery in Quantitative Proteomics
- (2015) Xiaomeng Shen et al. JOURNAL OF PROTEOME RESEARCH
- Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine
- (2015) Ming-Chen Yang et al. Molecular Cancer
- A secretomic study on human hepatocellular carcinoma multiple drug-resistant cell lines
- (2015) YI XIANG et al. ONCOLOGY REPORTS
- Zidovudine, an anti-viral drug, resensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine by inhibition of the Akt-GSK3β-Snail pathway
- (2015) T Namba et al. Cell Death & Disease
- The Genotype-Tissue Expression (GTEx) Project
- (2015) Latarsha J. Carithers et al. Biopreservation and Biobanking
- S100A4 promotes pancreatic cancer progression through a dual signaling pathway mediated by Src and focal adhesion kinase
- (2015) Pulin Che et al. Scientific Reports
- Interdependence of Gemcitabine Treatment, Transporter Expression, and Resistance in Human Pancreatic Carcinoma Cells
- (2015) Wolfgang Hagmann et al. NEOPLASIA
- Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma
- (2014) Kateryna Kondratska et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation
- (2014) D. Raha et al. CANCER RESEARCH
- The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells
- (2014) Frederik Köpper et al. CELL CYCLE
- Gelsolin regulates cisplatin sensitivity in human head-and-neck cancer
- (2014) Pei-Wen Wang et al. INTERNATIONAL JOURNAL OF CANCER
- Involvement of p38 mitogen-activated protein kinase in acquired gemcitabine-resistant human urothelial carcinoma sublines
- (2014) Yu-Ting Kao et al. KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
- Comparative Proteomic Profiling of Pancreatic Ductal Adenocarcinoma Cell Lines
- (2014) Yikwon Kim et al. MOLECULES AND CELLS
- The S100A4 D10V polymorphism is related to cell migration ability but not drug resistance in gastric cancer cells
- (2014) TEIN-MING YUAN et al. ONCOLOGY REPORTS
- Mass Spectrometry-Based Metabolic Profiling of Gemcitabine-Sensitive and Gemcitabine-Resistant Pancreatic Cancer Cells
- (2014) Yoshinori Fujimura et al. PANCREAS
- PharmGKB summary
- (2014) Maria L. Alvarellos et al. Pharmacogenetics and Genomics
- Cell fate regulation by gelsolin in human gynecologic cancers
- (2014) Mohammad R. Abedini et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of aldehyde dehydrogenase (ALDH) in cancer drug resistance
- (2013) Radosław Januchowski et al. BIOMEDICINE & PHARMACOTHERAPY
- The Genotype-Tissue Expression (GTEx) project
- (2013) John Lonsdale et al. NATURE GENETICS
- Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
- (2013) Daniel D. Von Hoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase
- (2013) N Weizman et al. ONCOGENE
- Double inhibition of NF-κB and XIAP via RNAi enhances the sensitivity of pancreatic cancer cells to gemcitabine
- (2013) LI-PING CAO et al. ONCOLOGY REPORTS
- Predictive value of ERCC1 and RRM1 gene single-nucleotide polymorphisms for first-line platinum- and gemcitabine-based chemotherapy in non-small cell lung cancer patients
- (2013) RADOSŁAW MLAK et al. ONCOLOGY REPORTS
- The Expression of S100A4 in Human Pancreatic Cancer Is Associated With Invasion
- (2013) Nobukazu Tsukamoto et al. PANCREAS
- RRM2B Suppresses Activation of the Oxidative Stress Pathway and is Up-regulated by P53 During Senescence
- (2012) Mei-Ling Kuo et al. Scientific Reports
- Effect of its deaminated metabolite, 2′,2′-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells
- (2011) L.S. Hodge et al. BIOCHEMICAL PHARMACOLOGY
- Creatine kinase brain overexpression protects colorectal cells from various metabolic and non-metabolic stresses
- (2011) Steven M. Mooney et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Proteomic analysis of gemcitabine-induced drug resistance in pancreatic cancer cells
- (2011) Yi-Wen Chen et al. Molecular BioSystems
- FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway
- (2011) Leanne Stevenson et al. PLoS One
- Overexpression of S100A4 in human cancer cell lines resistant to methotrexate
- (2010) Nuria Mencía et al. BMC CANCER
- Stromal biology and therapy in pancreatic cancer
- (2010) A. Neesse et al. GUT
- Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis
- (2010) Jennifer S. Carew et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer
- (2010) Lars Petter Jordheim et al. LANCET ONCOLOGY
- Oncoproteomic Analysis Reveals Co-Upregulation of RELA and STAT5 in Carboplatin Resistant Ovarian Carcinoma
- (2010) Natini Jinawath et al. PLoS One
- S100A4 and Metastasis
- (2009) Kjetil Boye et al. AMERICAN JOURNAL OF PATHOLOGY
- RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
- (2009) Takahiro Tabata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Acquisition of Epithelial-Mesenchymal Transition Phenotype of Gemcitabine-Resistant Pancreatic Cancer Cells Is Linked with Activation of the Notch Signaling Pathway
- (2009) Z. Wang et al. CANCER RESEARCH
- CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells
- (2009) Sung Pil Hong et al. INTERNATIONAL JOURNAL OF CANCER
- Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response
- (2009) Yong-Wei Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- IDPicker 2.0: Improved Protein Assembly with High Discrimination Peptide Identification Filtering
- (2009) Ze-Qiang Ma et al. JOURNAL OF PROTEOME RESEARCH
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
- (2009) Da Wei Huang et al. Nature Protocols
- Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma
- (2009) H Akita et al. ONCOGENE
- Pharmacokinetics of Gemcitabine and Metabolites in a Patient with Double-Sided Nephrectomy: A Case Report and Review of the Literature
- (2009) S. L.W. Koolen et al. ONCOLOGIST
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Broad Overexpression of Ribonucleotide Reductase Genes in Mice Specifically Induces Lung Neoplasms
- (2008) X. Xu et al. CANCER RESEARCH
- Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death
- (2008) Vitalia Sagulenko et al. CARCINOGENESIS
- Efficacy of Gemcitabine in Patients with Non-Small Cell Lung Cancer According to Promoter Polymorphisms of the Ribonucleotide Reductase M1 Gene
- (2008) S.-O. Kim et al. CLINICAL CANCER RESEARCH
- Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players
- (2008) M. P. Kim et al. CLINICAL CANCER RESEARCH
- Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer
- (2008) James J. Farrell et al. GASTROENTEROLOGY
- Measurement of Plasma Concentration of Gemcitabine and Its Metabolite dFdU in Hemodialysis Patients with Advanced Urothelial Cancer
- (2008) N. Masumori et al. JAPANESE JOURNAL OF CLINICAL ONCOLOGY
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