Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product

Biochemical Reconstitution Reveals the Biosynthetic Timing and Substrate Specificity for Thioamitides

(2022) Jiang Xiong et al.   ORGANIC LETTERS

Total In Vitro Biosynthesis of the Thioamitide Thioholgamide and Investigation of the Pathway

(2022) Asfandyar Sikandar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT

(2022) Raymond Sarksian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis and Heterologous Expression of Cacaoidin, the First Member of the Lanthidin Family of RiPPs

(2021) Fernando Román-Hurtado et al.   Antibiotics-Basel

Structural Analysis of Class I Lanthipeptides from Pedobacter lusitanus NL19 Reveals an Unusual Ring Pattern

(2021) Ian R. Bothwell et al.   ACS Chemical Biology

Discovery of new enzymatic functions and metabolic pathways using genomic enzymology web tools

(2021) Remi Zallot et al.   CURRENT OPINION IN BIOTECHNOLOGY

Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product

(2021) Alessio Caruso et al.   JOURNAL OF ORGANIC CHEMISTRY

Substrate plasticity of dehydratase SpaKC from the biosynthesis of thiosparsoamide

(2021) Ciji Wang et al.   JOURNAL OF PEPTIDE SCIENCE

Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM

(2021) Tung Le et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cacaoidin, first member of the new lanthidin RiPP family

(2020) Francisco Javier Ortiz-López et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional genome mining reveals a novel class V lanthipeptide containing a D‐amino acid introduced by an F420H2‐dependent reductase

(2020) Meifeng Tao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

(2020) Mark C. Walker et al.   BMC GENOMICS

Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides

(2020) Alexander M. Kloosterman et al.   PLOS BIOLOGY

Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides

(2019) Graham A. Hudson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis

(2016) Weixin Tang et al.   ACS Chemical Biology

Substrate-Controlled Stereochemistry in Natural Product Biosynthesis

(2015) Wei Ding et al.   ACS Chemical Biology

Michael-Type Cyclizations in Lantibiotic Biosynthesis Are Reversible

(2015) Xiao Yang et al.   ACS Chemical Biology

Peptide stapling techniques based on different macrocyclisation chemistries

(2015) Yu Heng Lau et al.   CHEMICAL SOCIETY REVIEWS

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

(2015) Shi-Hui Dong et al.   eLife

Structure and mechanism of lanthipeptide biosynthetic enzymes

(2014) Wilfred A van der Donk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and Biosynthesis of Carnolysin, a Homologue of Enterococcal Cytolysin with d-Amino Acids

(2014) Christopher T. Lohans et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

Substrate control in stereoselective lanthionine biosynthesis

(2014) Weixin Tang et al.   Nature Chemistry

Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis

(2013) Leif Flühe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry

(2013) Weixin Tang et al.   Nature Chemical Biology

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Evolution of lanthipeptide synthetases

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation, Structure Elucidation, and Synergistic Antibacterial Activity of a Novel Two-Component Lantibiotic Lichenicidin fromBacillus licheniformisVK21

(2010) Zakhar O. Shenkarev et al.   BIOCHEMISTRY

Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

(2010) Yuki Goto et al.   PLOS BIOLOGY