Article
Chemistry, Physical
Zhifei Xu, Qixuan Zhao, Di Zhao
Summary: Hydroxypropyl methylcellulose-poly (methacrylic acid) (HPMC-PMAA) nanogels were synthesized without surfactant at different pH values using HPMC as a template. The presence of MAA influenced the phase transition behavior of HPMC, with a stronger hydrogen bonding effect when the pH value was lower than the pKa value, resulting in a lower phase transition temperature. The nanogels prepared using this method showed the fastest preparation rate at pH 4.0.
COLLOID AND POLYMER SCIENCE
(2022)
Article
Chemistry, Physical
D. A. Romero-Fierro, L. A. Camacho-Cruz, M. R. Bustamante-Torres, S. P. Hidalgo-Bonilla, E. Bucio
Summary: The study proposed modifying cotton gauzes through grafting pH-sensitive polymers using gamma radiation as a means of achieving drug delivery. The successful modification of the devices was verified with analytical techniques, revealing novel properties such as a critical pH close to 4.7 for application to acidic skin wounds, and the ability to load antimicrobial drugs onto the grafted materials for development of antimicrobial materials.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Mohammadreza Ghaffarlou, S. Duygu Suetekin, Elif Karacaoglu, Secil Karahisar Turan, Ozlem Gueluem Inci, Olgun Gueven, Murat Barsbay
Summary: A novel nanogel composed of poly(acrylic acid) (PAA) and pullulan (Pull) was prepared using a simple and green irradiation protocol. The synthesized nanogels were modified with bovine serum albumin (BSA) and folic acid (FA), and then loaded with doxorubicin (DOX) to obtain a delivery system with tumor-specific targeting ability and enhanced biocompatibility. In vitro studies showed that the DOX release from the nanogels was higher in acidic media, which is advantageous for tumor targeting. MTT assay and DAPI staining demonstrated the effectiveness of DOX-loaded nanogels on cancer cells. Neat nanogels showed no destructive effects on both cell lines. Overall, the biocompatible and tumor-specific nanogels hold promise as safe drug carriers for cancer therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Lei Liu, Shujuan Luan, Chunli Zhang, Rui Wang, Yanan Zhang, Mengying Zhang, Qianli Sheng, Guang Han, Tianshun Wang, Shiyong Song
Summary: By introducing dopamine groups onto the skeleton of nanogels, efficient loading and pH-controlled release of bortezomib were achieved, leading to enhanced bioavailability and therapeutic effect of the drug. The pH-sensitive borated bonds between bortezomib and catechol groups endowed the drug with pH-responsive release behavior. In vivo experiments demonstrated that loading bortezomib into nanogels significantly enhanced its anti-tumor effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Kun Jiang, Gangyao Wen, Athanasios Skandalis, Stergios Pispas, Yanping Ding, Hongxu Chen
Summary: In this study, the aggregation behaviors of two pH-responsive amphiphilic diblock copolymers at the air/water interface were investigated under different subphase pH and temperature conditions. The results show that the surface pressure-molecular area isotherms of the copolymers exhibit a quasi-plateau under various subphase conditions, which is attributed to the pancake-to-brush transition as non-ionized PMAA chains submerge into the subphase upon monolayer compression. Additionally, the plateau surface pressures of the copolymers decrease with increasing temperature under different pH conditions.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Materials Science, Multidisciplinary
T. Plisko, K. S. Burts, A. Bildyukevich
Summary: The study focuses on the development of novel smart membranes for ultrafiltration that can reversibly change flux and HSA rejection in response to changes in pH and temperature of the feed solution. The smart membranes were prepared by immobilizing cross-linked dual-responsive chitosan-graft-poly(NIPAM) hydrogels on the surface of the microfiltration membrane.
MATERIALS & DESIGN
(2021)
Article
Polymer Science
Ting Fu, Jing Shen, Yuting Meng, Jun Wang, Siping Wang, Yuhui Zhang, Tongwen Wang, Xufeng Zhang
Summary: During the medication-assisted treatment of drug abuse, a thermo-sensitive nanogel was synthesized as a drug carrier to automatically deliver detoxification medicines. The nanogel displayed good biocompatibility and adjustable release characteristics, showing potential for controlled drug delivery in drug abuse treatment.
Article
Polymer Science
Shunying Li, Tingting Qin, Tingting Chen, Jun Wang, Qingbing Zeng
Summary: A series of pH-sensitive semi-interpenetrating polymer network hydrogels were synthesized and characterized in terms of their physicochemical properties. The hydrogels showed sensitivity to both pH and ionic strength, as well as good biocompatibility. Oral delivery of drug-loaded hydrogels demonstrated potential for reducing blood glucose levels.
IRANIAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
John R. Clegg, Jessie A. Sun, Joann Gu, Abhijeet K. Venkataraman, Nicholas A. Peppas
Summary: The study developed nanogels modified with bioactive peptides for targeted drug delivery. The modified nanogels showed enhanced co-localization with target cells, but adding endosome disrupting peptides may affect their targeting ability. The results demonstrate the need to further investigate methods to maintain endosome disrupting activity.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Environmental
Li-yue Sun, De-hao Yu, Zhao-ge Juan, Yao Wang, Yan-xin Wang, Matt J. Kipper, Lin-jun Huang, Jian-guo Tang
Summary: Graphene oxide (GO) membranes can be used for water treatment to remove organic molecules. However, the effect of pH on GO's properties leads to poor removal of positively charged model compounds. In this study, pH-responsive polymers were used to modify GO membranes, resulting in improved removal performance, water permeance, and long-term stability.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Polymer Science
Arielle L. Santefort, Philip A. Yuya, Devon A. Shipp
Summary: The dynamic covalent exchange of anhydride moieties in highly crosslinked poly(methacrylic anhydride) (PMAA) was investigated through recycling processes. The formation of cyclic anhydrides was observed and confirmed using IR spectroscopy. Computational analysis showed that cyclic anhydrides have higher strain than acyclic anhydrides. The observed cyclization explains the changes in material properties of PMAA.
Article
Polymer Science
Madhappan Santhamoorthy, Thi Tuong Vy Phan, Vanaraj Ramkumar, Chaitany Jayprakash Raorane, Kokila Thirupathi, Seong-Cheol Kim
Summary: In this study, a dual pH- and thermo-sensitive copolymer hydrogel system was prepared and characterized. The hydrogel showed temperature-responsive drug release behavior and high drug loading efficiency. It demonstrated good biocompatibility on liver cancer cells, making it a potential drug delivery carrier for solid tumor-targeted therapy.
Article
Polymer Science
Sobia Noreen, Fahad Pervaiz, Muhamamd Ijaz, Hina Shoukat
Summary: The study developed a novel pH-sensitive interpenetrating network (IPN) of hyaluronic acid/Poloxamer 407-co-poly (Methacrylic acid) for targeted delivery of 5-fluorouracil to colonic receptors. The hydrogels demonstrated pH-dependent drug release behavior and biocompatibility in a rabbit model. This suggests that the manufactured hydrogels could be potentially used for controlled and targeted delivery of 5-fluorouracil.
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yan Li, Jing-Wen Wang, Qiu-Shi Dong, Bao-Chang Zhao, Ji-Mei Zhang, Yan-Ling Li, Zhi-Guo Lu, Xin Zhang
Summary: In this study, dual pH and temperature-sensitive nanogels loaded with eugenol were successfully prepared and applied to silk. The results showed that this nano-fragrance had significant and positive effects on stress relief, anti-anxiety, and spatial learning and memory.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xu Cheng, Ting Hu, Conghu Li, Shuiqin Shi, Yingran Xu, Chaochao Jia, Rupei Tang
Summary: The development of acid-sensitive and pluronic L61linked hyaluronic acid nanogels showed promising results in increasing intracellular drug concentration, enhancing cell-killing effect on MDR cells, and achieving specific accumulation and tumor growth inhibition in vivo. These findings suggest the potential for clinical application in MDR tumor therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Masahiko Nakamoto, Di Zhao, Olivia Rose Benice, Shih-Hui Lee, Kenneth J. Shea
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Review
Pharmacology & Pharmacy
Fangli Mo, Kai Jiang, Di Zhao, Yuqi Wang, Jie Song, Weihong Tan
Summary: DNA hydrogels, comprised of crosslinked DNA chains in hydrophilic polymeric networks, are widely studied in bioanalysis and biomedicine due to their biocompatibility, porosity, sequence programmability, and tunable multifunctionality. Methods for constructing DNA hydrogels and their responses to stimuli are introduced, along with detailed discussion on DNA hydrogel-based drug delivery platforms and future prospects for combining DNA hydrogels with gene editing tools in gene therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Biomedical
Di Zhao, Kai Jiang, Yuqi Wang, Jin Cheng, Fangli Mo, Tao Luo, Yuanyuan Guo, Chuan Zhang, Jie Song
Summary: Nanocapsules provide an effective platform for targeted drug delivery, overcoming challenges in anticancer drug solubility, toxicity, and multidrug resistance. Their simple design allows for high drug loading efficiency and synergy therapy, with capabilities of enzyme-triggering and lung targeting. This system demonstrates effective tumor inhibition and vascular proliferation without systemic toxicity, offering a universal strategy for targeted lung delivery, enzyme triggering, and synergy therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Shunsuke Onogi, Shih-Hui Lee, Krista R. Fruehauf, Kenneth J. Shea
Summary: This approach utilizes synthetic hydrogel copolymers to selectively capture proteins by tuning their composition and polymerization conditions. The protein affinity reagent (PAR) can be rapidly synthesized in a chemistry laboratory without the need for living cells, and can reversibly capture and release proteins without denaturation under specific conditions.
Article
Chemistry, Multidisciplinary
Masahiko Nakamoto, Teresa Escalante, Jose M. Gutierrez, Kenneth J. Shea
Summary: A biomimetic of endogenous tissue inhibitors of metalloproteinases was engineered with three binding elements, showing inhibition of snake venom metalloproteinase. The size of the polymer contributed to inhibition efficacy, while a low crosslinked polymer hydrogel nanoparticle had comparable efficacy, suggesting potential for in vivo applications. The abiotic TIMP was effective against two classes of SVMPs in whole snake venom, serving as a design principle for biomimetic polymer inhibitors of enzymes.
Article
Materials Science, Biomaterials
Tong Zhang, Kamaran Khurshid Dar, Yuan Li, Jing Guo, Weiliang Sun, Kenneth J. Shea, Tianwei Tan, Yongqin Lv
Summary: An inhibitor for MMP-9 has been designed based on molecularly imprinted nanoparticles, showing selective inhibition of MMP-9 activity. This new approach effectively suppresses tumor migration and growth, offering a promising paradigm for cancer therapy engineering.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Electrochemistry
Taylor L. Frey, Krista R. Fruehauf, Rachel A. Lucas, Jake W. Polster, Kenneth J. Shea, Zuzanna S. Siwy
Summary: This study investigates the application of solid state nanopores based on PIMs in ion transport and interactions. By controlling the pore structure and selecting functional groups, nanopore channels with consistent sizes can be achieved, and the interactions between ions and molecules inside the pores can be modified, opening up new avenues for water purification and energy storage.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Nanoscience & Nanotechnology
Qiaolian Cheng, Xiaoyang Yu, Zhouxuan Xiong, Zihao Wan, Yuxin Li, Weihua Ma, Wenfeng Tan, Mingming Liu, Kenneth J. Shea
Summary: This study presents a synthetic antibody (SA) that can bind to Bt Cry proteins. The SA, APhe-NP23, shows affinity and selectivity for Bt Cry1Ab/Ac proteins and inhibits their binding to insect receptors. These findings contribute to the concept that randomness and biospecificity are not mutually exclusive.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Polymer Science
Zuobing Xiao, Huiqin Liu, Qixuan Zhao, Yunwei Niu, Ziqian Chen, Di Zhao
Summary: This article introduces the application of microencapsulation technology in silk fiber. By encapsulating functional materials, the value of silk can be enhanced and new functions can be added. Microcapsules can protect the functional materials and release them under specific external conditions to achieve the desired effects.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Wenxin Zhang, Lili Qiu, Kenneth J. Shea, Jing Fan, Yangyang Liu, Wenxiang Zheng, Min Xue, Wenfang Liu, Zhibin Xu, Xiu-tian-feng E, Xiao Dong, Yu Qiao, Zihui Meng
Summary: This study analyzes the structural color of photonic crystals using the HSB color space and demonstrates that the analysis based on hue value (H) can achieve accuracy comparable to spectrum analysis. Quantitative analysis of stimulus-responsive PhCs structural color is also possible using this method. This analysis method provides a convenient technology for general users.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xiaoxiao Li, Xueting Li, Tingting Xia, Wei Chen, Kenneth J. Shea, Xihua Lu
Summary: It is discovered that introducing hydrophobic N-tert-butylacrylamide (TBA) with large sterically hindering side groups can slow down the dehydration of hydrophobic alkyl groups in PNIPAm-based nanogels, resulting in thermally induced sol-gel transition above the phase transition temperature (T-p). Furthermore, the introduction of N-acrylamido-L-phenylalanine (APhe) monomer with a strongly water-absorbing carboxyl group and larger steric hindrance can self-assemble PNIPAm/TBA/APhe terpolymer nanogels into colorful colloidal crystals that undergo sol-gel transition above T-p.
MATERIALS HORIZONS
(2023)
Review
Chemistry, Physical
Zuobing Xiao, Qixuan Zhao, Yunwei Niu, Di Zhao
Summary: This review discusses the significance of the field of adhesion and the application of nanotechnology in achieving adhesion. The study of biomimetic adhesion inspired by biological systems has provided new insights and directions for the development of adhesive materials.
Article
Nanoscience & Nanotechnology
Shih-Hui Lee, Issa Moody, Zhiyang Zeng, Everly B. Fleischer, Gregory A. Weiss, Kenneth J. Shea
Summary: By utilizing phage display, high affinity peptide-polymer nanoparticle pairs can be selected. The affinity is derived from complementary physiochemical properties and specific peptide sequences, with peptide structure also contributing to the affinity. These findings present a general method for identifying polymer-peptide complementary pairs.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yuqi Wang, Jin Cheng, Di Zhao, Yan Liu, Tao Luo, Yi-Fang Zhong, Fangli Mo, Xiang-Yang Kong, Jie Song
Article
Polymer Science
Jose E. Baez, Kenneth J. Shea, Philip R. Dennison, Armando Obregon-Herrera, Jose Bonilla-Cruz
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
