Correction
Medicine, General & Internal
P. Mbala-Kingebeni
Summary: This article highlights that a misspelled surname of one of the authors has affected the content about Ebola virus transmission.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Virology
Sophie J. Smither, Lin S. Eastaugh, Mark S. Lever
Summary: During virus disease outbreaks, various variants may emerge, some of which may pose a concern. This study investigated the stability of several Ebola and Marburg virus variants in aerosols. The results showed no significant difference in the decay rates of the variants. In addition, it was found that Ebola virus Kikwit was less virulent than Ebola virus Ecran in a mouse model.
Article
Cell Biology
Ermela Paparisto, Nina R. Hunt, Daniel S. Labach, Macon D. Coleman, Eric J. Di Gravio, Mackenzie J. Dodge, Nicole J. Friesen, Marceline Cote, Andreas Muller, Thomas Hoenen, Stephen D. Barr
Summary: Survival after Ebola virus infection is closely linked to an early and robust interferon response. Research has identified that the IFN-induced HERC5 protein can inhibit EBOV replication by depleting viral mRNAs, and also shows an antagonist relationship with the virus glycoprotein during early infection, potentially leading to the development of novel antiviral therapeutics.
Article
Immunology
Daniela Manno, Philip Ayieko, David Ishola, Muhammed O. Afolabi, Baimba Rogers, Frank Baiden, Alimamy Serry-Bangura, Osman M. Bah, Brian Kohn, Ibrahim Swaray, Kwabena Owusu-Kyei, Godfrey T. Otieno, Dickens Kowuor, Daniel Tindanbil, Elizabeth Smout, Cynthia Robinson, Babajide Keshinro, Julie Foster, Katherine Gallagher, Brett Lowe, Macaya Douoguih, Bailah Leigh, Brian Greenwood, Deborah Watson-Jones
Summary: This study investigated the association between Ebola virus antibody seropositivity and concentration, and potential risk factors for infection. Among 1,282 adults and children from a community affected by the 2014-2016 Ebola outbreak in Sierra Leone, 8% tested positive for virus antibodies without experiencing any disease symptoms. Antibody concentration was found to increase with age.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Mila Collados Rodriguez, Patrick Maillard, Alexandra Journeaux, Anastassia V. Komarova, Valerie Najburg, Raul-Yusef Sanchez David, Olivier Helynck, Mingzhe Guo, Jin Zhong, Sylvain Baize, Frederic Tangy, Yves Jacob, Helene Munier-Lehmann, Eliane F. Meurs
Summary: Researchers have identified two compounds that can inhibit infection by Ebola virus and measles virus. These compounds exert antiviral effects by restoring intrinsic immunity. Further testing on other species and negative-sense RNA viruses is needed to evaluate their effectiveness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Pradakshina Sharma, Shariq Suleman, Asim Farooqui, Wajid Ali, Jagriti Narang, Shweta J. Malode, Nagaraj P. Shetti
Summary: This article introduces the diagnosis strategies for Ebola virus and the use of advanced technologies such as artificial intelligence and the internet of medical things for disease diagnosis. Timely disease identification and treatment optimization are crucial for controlling infectious disease outbreaks.
MICROCHEMICAL JOURNAL
(2022)
Review
Virology
Toufik Abdul-Rahman, Lukman Lawal, Emily Meale, Oyinbolaji A. Ajetunmobi, Soyemi Toluwalashe, Uthman Hassan Alao, Shankhaneel Ghosh, Neil Garg, Abdullahi Tunde Aborode, Andrew Awuah Wireko, Aashna Mehta, Kateryna Sikora
Summary: The Ebola virus has caused multiple outbreaks in Africa with high fatality rates. Social factors such as human mobility, behavior, and cultural norms contribute to the transmission risk. However, challenges including lagging vaccine production pose a risk of another outbreak.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Ching-Hsuan Liu, Yee-Tung Hu, Shu Hui Wong, Liang-Tzung Lin
Summary: Since the 2014-2016 epidemic, Ebola virus has become a major threat to global health. Despite the approval of several anti-Ebola vaccines and therapeutics, the high fatality rate highlights the need for continuous development of antiviral strategies.
Review
Microbiology
Sahil Jain, Ekaterina Martynova, Albert Rizvanov, Svetlana Khaiboullina, Manoj Baranwal
Summary: The article presents the genetic composition of the Ebola virus and the encoding of its proteins, analyzes the roles of different proteins in the pathogenesis of the disease, and provides an overview of the Ebola virus and its life cycle.
Article
Medicine, General & Internal
Supriya Ravichandran, Surender Khurana
Summary: A serodiagnostic test has been developed to differentiate between individuals with EBOV infection-induced antibodies and those with EBOV vaccine-induced antibodies. This test can accurately detect Ebola virus infections and could be implemented as a robust diagnostic tool for epidemiology and surveillance during and after outbreaks, especially in countries with mass Ebola vaccinations.
Article
Virology
Marcel Bokelmann, Uwe Vogel, Franka Debeljak, Ariane Duex, Silke Riesle-Sbarbaro, Angelika Lander, Annette Wahlbrink, Nicole Kromarek, Stuart Neil, Emmanuel Couacy-Hymann, Joseph Prescott, Andreas Kurth
Summary: Recent studies suggest that the Angolan free-tailed bat may be a possible reservoir for Ebola virus, with bat cells showing high tolerance and the virus's ability to persist without mutation for up to 150 days. This provides further evidence for the role of this bat species as a likely reservoir for ebolaviruses.
Article
Immunology
Sidy Bane, Kyle Rosenke, Ousmane Maiga, Friederike Feldmann, Kimberly Meade-White, Julie Callison, David Safronetz, Nafomon Sogoba, Heinz Feldmann
Summary: The study suggests low seroprevalence of Ebola virus or closely related viruses in southern Mali, indicating limited exposure in the population.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Arthur Viode, Kinga K. Smolen, Benoit Fatou, Zainab Wurie, Patrick Van Zalm, Mandy Kader Konde, Balla Moussa Keita, Richard Amento Ablam, Eleanor N. Fish, Hanno Steen
Summary: In this study, the plasma proteomes of 12 individuals infected with Ebola virus (EBV) were characterized using two different LC-MS-based proteomics platforms and an antibody-based multiplexed cytokine/chemokine assay. Clear differences were observed in the host proteome between individuals who survived and those who died, at both early and late stages of the disease. A prognostic biomarker panel of 4 proteins was derived from the analysis, which may help guide care and can be easily implemented in resource-limited regions.
Article
Multidisciplinary Sciences
Bin Yuan, Qi Peng, Jinlong Cheng, Min Wang, Jin Zhong, Jianxun Qi, George F. Gao, Yi Shi
Summary: Filoviruses, including Ebola virus, pose an increasing threat to public health. The structure of the Ebola virus L protein in complex with VP35 has been determined, revealing potential targets for anti-filovirus drugs. Additionally, suramin has been found to inhibit the activity of the Ebola virus polymerase.
Article
Immunology
Axel T. Lehrer, Eleanore Chuang, Madhuri Namekar, Caitlin A. Williams, Teri Ann S. Wong, Michael M. Lieberman, Alex Granados, John Misamore, Jake Yalley-Ogunro, Hanne Andersen, Joan B. Geisbert, Krystle N. Agans, Robert W. Cross, Thomas W. Geisbert
Summary: The recombinant subunit vaccine platform shows potential in preventing Ebola, Marburg, and Sudan Virus Disease, with candidate vaccines eliciting potent immune responses in animal studies and providing effective protection against lethal virus infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Jason E. Shoemaker, Satoshi Fukuyama, Amie J. Eisfeld, Dongming Zhao, Eiryo Kawakami, Saori Sakabe, Tadashi Maemura, Takeo Gorai, Hiroaki Katsura, Yukiko Muramoto, Shinji Watanabe, Tokiko Watanabe, Ken Fuji, Yukiko Matsuoka, Hiroaki Kitano, Yoshihiro Kawaoka
Article
Biochemical Research Methods
Zhen Niu, Deborah Chasman, Amie J. Eisfeld, Yoshihiro Kawaoka, Sushmita Roy
Article
Mathematical & Computational Biology
Jason E. McDermott, Hugh D. Mitchell, Lisa E. Gralinski, Amie J. Eisfeld, Laurence Josset, Armand Bankhead, Gabriele Neumann, Susan C. Tilton, Alexandra Schafer, Chengjun Li, Shufang Fan, Shannon McWeeney, Ralph S. Baric, Michael G. Katze, Katrina M. Waters
BMC SYSTEMS BIOLOGY
(2016)
Article
Microbiology
Jennifer Tisoncik-Go, David J. Gasper, Jennifer E. Kyle, Amie J. Eisfeld, Christian Selinger, Masato Hatta, Juliet Morrison, Marcus J. Korth, Erika M. Zink, Young-Mo Kim, Athena A. Schepmoes, Carrie D. Nicora, Samuel O. Purvine, Karl K. Weitz, Xinxia Peng, Richard R. Green, Susan C. Tilton, Bobbie-Jo Webb-Robertson, Katrina M. Waters, Thomas O. Metz, Richard D. Smith, Yoshihiro Kawaoka, M. Suresh, Laurence Josset, Michael G. Katze
CELL HOST & MICROBE
(2016)
Article
Biochemical Research Methods
Deborah Chasman, Kevin B. Walters, Tiago J. S. Lopes, Amie J. Eisfeld, Yoshihiro Kawaoka, Sushmita Roy
PLOS COMPUTATIONAL BIOLOGY
(2016)
Editorial Material
Biochemistry & Molecular Biology
Amie J. Eisfeld, Yoshihiro Kawaoka
Article
Multidisciplinary Sciences
Vineet D. Menachery, Alexandra Schafer, Kristin E. Burnum-Johnson, Hugh D. Mitchell, Amie J. Eisfeld, Kevin B. Walters, Carrie D. Nicora, Samuel O. Purvine, Cameron P. Casey, Matthew E. Monroe, Karl K. Weitz, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Lisa E. Gralinski, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Amy C. Sims, Yoshihiro Kawaoka, Ralph S. Baric
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Microbiology
Amie J. Eisfeld, David J. Gasper, M. Suresh, Yoshihiro Kawaoka
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
J. E. Kyle, K. E. Burnum-Johnson, J. P. Wendler, A. J. Eisfeld, Peter J. Halfmann, Tokiko Watanabe, Foday Sahr, R. D. Smith, Y. Kawaoka, K. M. Waters, T. O. Metz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Infectious Diseases
Peter J. Halfmann, Amie J. Eisfeld, Tokiko Watanabe, Tadashi Maemura, Makoto Yamashita, Satoshi Fukuyama, Tammy Armbrust, Isaiah Rozich, Alhaji N'jai, Gabriele Neumann, Yoshihiro Kawaoka, Foday Sahr
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Cell Biology
Hugh D. Mitchell, Amie J. Eisfeld, Kelly G. Stratton, Natalie C. Heller, Lisa M. Bremer, Ji Wen, Jason E. McDermott, Lisa E. Gralinski, Amy C. Sims, Mai Q. Le, Ralph S. Baric, Yoshihiro Kawaoka, Katrina M. Waters
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Lisa M. Bramer, Robert D. Hontz, Amie J. Eisfeld, Amy C. Sims, Young-Mo Kim, Kelly G. Stratton, Carrie D. Nicora, Marina A. Gritsenko, Athena A. Schepmoes, Osamu Akasaka, Michiko Koga, Takeya Tsutsumi, Morio Nakamura, Ichiro Nakachi, Rie Baba, Hiroki Tateno, Shoji Suzuki, Hideaki Nakajima, Hideaki Kato, Kazunari Ishida, Makoto Ishii, Yoshifumi Uwamino, Keiko Mitamura, Vanessa L. Paurus, Ernesto S. Nakayasu, Isaac K. Attah, Andrew G. Letizia, Katrina M. Waters, Thomas O. Metz, Karen Corson, Yoshihiro Kawaoka, Vincent R. Gerbasi, Hiroshi Yotsuyanagi, Kiyoko Iwatsuki-Horimoto
Summary: To better understand the pathology of COVID-19, a multi-omics and correla-tive analysis was conducted on a clinical cohort. Severe patients exhibited elevated levels of pulmonary surfactant, while mild patients showed an increase in the carnosine dipeptidase modifying enzyme (CNDP1). Both mild and severe patients had elevated L-cystine and enzymes related to glutathione metabolism. Neutrophil extracellular traps (NETs) were observed in both patient groups, with higher formation in severe cases. CNDP1 may play a protective role in suppressing PSPB release, while NET formation is correlated with increased PSPB levels and disease severity, potentially leading to pulmonary occlusions.
Article
Microbiology
Amie J. Eisfeld, Peter J. Halfmann, Jason P. Wendler, Jennifer E. Kyle, Kristin E. Burnum-Johnson, Zuleyma Peralta, Tadashi Maemura, Kevin B. Walters, Tokiko Watanabe, Satoshi Fukuyama, Makoto Yamashita, Jon M. Jacobs, Young-Mo Kim, Cameron P. Casey, Kelly G. Stratton, Bobbie-Jo M. Webb-Robertson, Marina A. Gritsenko, Matthew E. Monroe, Karl K. Weitz, Anil K. Shukla, Mingyuan Tian, Gabriele Neumann, Jennifer L. Reed, Harm van Bakel, Thomas O. Metz, Richard D. Smith, Katrina M. Waters, Alhaji N'jai, Foday Sahr, Yoshihiro Kawaoka
CELL HOST & MICROBE
(2017)
Article
Chemistry, Analytical
Kristin E. Burnum-Johnson, Jennifer E. Kyle, Amie J. Eisfeld, Cameron P. Casey, Kelly G. Stratton, Juan F. Gonzalez, Fabien Habyarimana, Nicholas M. Negretti, Amy C. Sims, Sadhana Chauhan, Larissa B. Thackray, Peter J. Halfmann, Kevin B. Walters, Young-Mo Kim, Erika M. Zink, Carrie D. Nicora, Karl K. Weitz, Bobbie-Jo M. Webb-Robertson, Ernesto S. Nakayasu, Brian Ahmer, Michael E. Konkel, Vladimir Motin, Ralph S. Baric, Michael S. Diamond, Yoshihiro Kawaoka, Katrina M. Waters, Richard D. Smith, Thomas O. Metz
