HIV Protease Inhibitor–Induced Cathepsin Modulation Alters Antigen Processing and Cross-Presentation

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells

(2015) Kensuke Takada et al.   NATURE IMMUNOLOGY

CD169+macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells

(2015) Caroline A. Bernhard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape

(2015) Jens Dinter et al.   PLoS Pathogens

Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy

(2014) Joell J. Gills et al.   Autophagy

Different Antigen-Processing Activities in Dendritic Cells, Macrophages, and Monocytes Lead to Uneven Production of HIV Epitopes and Affect CTL Recognition

(2014) Jens Dinter et al.   JOURNAL OF IMMUNOLOGY

Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors

(2014) G. Kourjian et al.   JOURNAL OF IMMUNOLOGY

The immune epitope database (IEDB) 3.0

(2014) Randi Vita et al.   NUCLEIC ACIDS RESEARCH

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells

(2013) Archana Vaithilingam et al.   BMC CELL BIOLOGY

Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention

(2013) Soren Gantt et al.   CURRENT OPINION IN ONCOLOGY

Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cells

(2012) B. Chatterjee et al.   BLOOD

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Variable HIV peptide stability in human cytosol is critical to epitope presentation and immune escape

(2011) Estibaliz Lazaro et al.   JOURNAL OF CLINICAL INVESTIGATION

HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control

(2011) H. N. Kloverpris et al.   JOURNAL OF VIROLOGY

Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome

(2010) Carmen M Diez-Rivero et al.   BMC BIOINFORMATICS

Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans

(2010) John P. Plastaras et al.   CANCER BIOLOGY & THERAPY

HIV Infection–Associated Tuberculosis: The Epidemiology and the Response

(2010) Haileyesus Getahun et al.   CLINICAL INFECTIOUS DISEASES

Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

(2010) Takeshi Nitta et al.   IMMUNITY

Viral hepatitis and HIV co-infection

(2009) Vincent Soriano et al.   ANTIVIRAL RESEARCH

Exclusive expression of proteasome subunit  5t in the human thymic cortex

(2009) U. Tomaru et al.   BLOOD

p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

(2009) Jamel El-Benna et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Differential HIV Epitope Processing in Monocytes and CD4 T Cells Affects Cytotoxic T Lymphocyte Recognition

(2009) Estibaliz Lazaro et al.   JOURNAL OF INFECTIOUS DISEASES

Receptor-mediated phagocytosis elicits cross-presentation in nonprofessional antigen-presenting cells

(2009) A. Giodini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

(2009) R. Belizaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication

(2008) Donatella Ciuffreda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY