Article
Environmental Sciences
Yan Zhang, Ding Yuan, Yi Li, Fang Yang, Linlin Hou, Yanwu Yu, Changhua Sun, Guoyu Duan, Cuicui Meng, Hongyi Yan, Dongxu Li, Yanxia Gao, Tongwen Sun, Changju Zhu
Summary: The study found that paraquat regulates the polarization of alveolar macrophages through glycolysis, promoting acute lung injury in rats. In vivo, lung pathological damage in rats gradually increased after paraquat poisoning, and the toxic effect on alveolar macrophages was dose- and time-dependent.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Haiying Ji, Chengmi Zhang, Fengying Xu, Qianyun Mao, Ran Xia, Muqiao Chen, Wei Wang, Shunan Lv, Weiwei Li, Xueyin Shi
Summary: Inspired by the intrinsic recovery mechanism of efferocytosis, researchers have developed an inhalable nanozyme that promotes apoptotic cell removal and inhibits inflammation, thus alleviating acute lung injury. This nanozyme effectively mimics the signals of apoptotic bodies and scavenges excessive reactive oxygen species, addressing a critical factor in the pathogenesis of sepsis-related ALI.
Article
Pharmacology & Pharmacy
Ding Yuan, Yi Li, Linlin Hou, Fang Yang, Cuicui Meng, Yanwu Yu, Changhua Sun, Guoyu Duan, Zhigao Xu, Guiying Zhu, Jianjun Guo, Leilei Zhang, Gaiqin Yan, Jihong Chen, Yanan Yang, Yan Zhang, Yanxia Gao
Summary: This study found that metformin can protect rats from acute lung injury caused by paraquat poisoning by regulating the polarization of alveolar macrophages. In in vivo experiments, metformin increased the survival rate of rats, alleviated lung pathological damages and systemic inflammation, reduced the levels of pro-inflammatory factors IL-6 and TNF-alpha, and increased the level of anti-inflammatory factor IL-10. In in vitro experiments, low concentrations of metformin protected alveolar macrophages from paraquat-induced damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Lian Wang, Dongguang Wang, Tianli Zhang, Yao Ma, Xiang Tong, Hong Fan
Summary: Lung macrophages play a crucial role in defending against airborne particles and microbes. They are also involved in the development of acute lung injury and acute respiratory distress syndrome by modulating inflammatory responses and repairing damaged lung tissues. Macrophage polarization, which is regulated by immunometabolism and its intermediates, may provide new therapeutic targets for ALI/ARDS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Jianhua Zhang, Wanyi Tian, Fang Wang, Jiao Liu, Jiang Huang, Suwit Duangmano, Hao Liu, Minghua Liu, Zhuo Zhang, Xian Jiang
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by severe dyspnea and respiratory distress, often caused by damage to the alveolar epithelium and capillary endothelial cells. Macrophages, exhibiting different polarized forms, play a crucial role in the progression of ALI/ARDS. MicroRNAs (miRNAs), as potential markers for diseases, are involved in various biological processes and regulate macrophage polarization during ALI/ARDS.
Article
Biochemistry & Molecular Biology
Li Ma, Yan-Qing Chen, Zhi-Jian You, Zhong-Sheng Jiang, Yu Fang, Liang Dong
Summary: Intermittent fasting (IF) enhances M2 polarization by activating the AMPK and PPAR gamma pathways, thereby facilitating anti-inflammatory response and ameliorating acute lung injury (ALI).
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ya-Xian Wu, Feng-Juan Jiang, Gang Liu, Ying-Ying Wang, Zhi-Qi Gao, Si-Hao Jin, Yun-Juan Nie, Dan Chen, Jun-Liang Chen, Qing-Feng Pang
Summary: Dehydrocostus lactone (DHL) was found to promote macrophage polarization towards the anti-inflammatory M2 phenotype by modulating multiple signaling pathways, reducing inflammatory response, and potentially serving as a therapeutic candidate for inflammatory diseases caused by Gram-positive bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiang Li, Chuan Xiao, Jia Yuan, Xianjun Chen, Qing Li, Feng Shen
Summary: Rhein promotes macrophage M2 polarization transition by targeting the NFATc1/Trem2 axis to regulate inflammation response and prognosis after ALI/ARDS, which sheds more light on possibilities for the clinical treatments of this pathological process.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Hui Guo, Yan Song, Fanjian Li, Yan Fan, Yiman Li, Chaonan Zhang, Huijie Hou, Minmin Shi, Zilong Zhao, Zhe Chen
Summary: This study found that ACT001 significantly alleviates inflammation and limits the M1 phenotype of pulmonary macrophages by suppressing NF-Kappa B and STAT1 signaling pathways in acute lung injury (ALI).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jin Zhang, Changsong Wang, Hongliang Wang, Xueting Li, Jingjing Xu, Kaijiang Yu
Summary: The study demonstrates that Loganin exerts anti-inflammatory effects by improving survival rate, reducing lung damage, and inhibiting inflammation in murine sepsis-induced acute lung injury through modulation of cytokine expression and NLRP3 inflammasome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shengsong Chen, Jingen Xia, Yi Zhang, Qingyuan Zhan
Summary: IL35 alleviated LPS-induced inflammation and ALI in mice by regulating M1/M2 macrophage polarization and inhibiting the activation of the TLR4/NF kappa B-P65 pathway.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Almaz Zaki, M. Shadab Ali, Vijay Hadda, Syed Mansoor Ali, Anita Chopra, Tasneem Fatma
Summary: Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are major causes of ICU death, characterized by severe hypoxemia and inflammation leading to poor lung compliance. Long non-coding RNA (lncRNA) has been shown to be abundantly expressed in ALI and targeting lncRNAs can alleviate ALI. Therefore, lncRNAs hold promise as potential therapeutic targets for ALI.
Article
Biochemistry & Molecular Biology
Xiaoyang Wu, Lili Wu, Ya Wu, Wei Chen, Jinkun Chen, Lirong Gong, Jianbo Yu
Summary: Acute lung injury (ALI) is a global public health issue without specific and effective treatment options. This study investigated the therapeutic effects of heme oxygenase-1 (HO-1) on ALI and its involvement in alveolar macrophage polarization. The results showed that HO-1 depletion increased M1 phenotype expression and decreased M2 phenotype expression in alveolar macrophages. HO-1 depletion also accelerated the expression of inflammasome-associated components. Furthermore, HO-1 was found to modulate macrophage polarization through the TXNIP/NLRP3 signaling pathway. These findings suggest that HO-1 could be a potential therapeutic target for ALI treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Shishuo Sun, Yizhou Yao, Chao Huang, Heng Xu, Yuxiao Zhao, Yifei Wang, Yizhang Zhu, Yangna Miao, Xinhui Feng, Xiaoge Gao, Junnian Zheng, Qing Zhang
Summary: Loss of CD36 attenuates LPS-induced ALI by reducing M1 polarization of macrophages.
CELLULAR IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Maomao Sun, Zhenhua Zeng, Gege Xu, Sheng An, Zhiya Deng, Ran Cheng, Yi Yao, Junjie Wu, Hongbin Hu, Qiaobing Huang, Jie Wu
Summary: This study revealed that the mitochondrial dynamics of alveolar macrophages (AMs) are imbalanced in sepsis and acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), characterized by impaired mitochondrial fusion, increased fission, and mitochondrial cristae remodeling. Modulating mitochondrial dynamics by suppressing excessive fission or promoting fusion can inhibit the polarization of AMs into a proinflammatory phenotype and attenuate sepsis-induced ALI.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)