Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway

Belatacept and Long-Term Outcomes in Kidney Transplantation

(2016) Flavio Vincenti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective CD28 Antagonist Blunts Memory Immune Responses and Promotes Long-Term Control of Skin Inflammation in Nonhuman Primates

(2015) Nicolas Poirier et al.   JOURNAL OF IMMUNOLOGY

CD28 Negative T Cells: Is Their Loss Our Gain?

(2014) D. Mou et al.   AMERICAN JOURNAL OF TRANSPLANTATION

2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+T cell responses

(2014) Danya Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity

(2014) E. M. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Candida-Elicited Murine Th17 Cells Express High CTLA-4 Compared with Th1 Cells and Are Resistant to Costimulation Blockade

(2014) S. M. Krummey et al.   JOURNAL OF IMMUNOLOGY

Ipilimumab in patients with melanoma and autoimmune disease

(2014) Chrisann Kyi et al.   Journal for ImmunoTherapy of Cancer

A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation

(2013) Amit D. Parulekar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-Term Belatacept Exposure Maintains Efficacy and Safety at 5 Years: Results From the Long-Term Extension of the BENEFIT Study

(2013) L. Rostaing et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Monovalent Anti-Human CD28 Domain Antibody Antagonist: Preclinical Efficacy and Safety

(2013) S. J. Suchard et al.   JOURNAL OF IMMUNOLOGY

Preclinical Efficacy and Immunological Safety of FR104, an Antagonist Anti-CD28 Monovalent Fab′ Antibody

(2012) N. Poirier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Deleterious Effect of CTLA4-Ig on a Treg-Dependent Transplant Model

(2012) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Abatacept for Crohn's Disease and Ulcerative Colitis

(2012) William J. Sandborn et al.   GASTROENTEROLOGY

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Belatacept-Based Regimens Are Associated With Improved Cardiovascular and Metabolic Risk Factors Compared With Cyclosporine in Kidney Transplant Recipients (BENEFIT and BENEFIT-EXT Studies)

(2011) Yves Vanrenterghem et al.   TRANSPLANTATION

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

(2010) J. T. Merrill et al.   ARTHRITIS AND RHEUMATISM

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

(2008) J. A. Bluestone et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial

(2008) V. Viglietta et al.   NEUROLOGY

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE