Article
Oncology
Li Wang, Xingguo Song, Miao Yu, Limin Niu, Yajing Zhao, Youyong Tang, Baibing Zheng, Xianrang Song, Li Xie
Summary: This study identified downregulated exosomal miR-377-3p and miR-381-3p in CRC patients, serving as circulating biomarkers for the diagnosis of CRC, especially for early-stage detection.
Article
Oncology
Yong-Zheng Yu, Qiang Mu, Qian Ren, Li-Juan Xie, Qi-Tang Wang, Cui-Ping Wang
Summary: miR-381-3p expression was significantly decreased in breast cancer tissues and cell lines. Overexpression of miR-381-3p inhibited breast cancer proliferation and invasion, while knockdown promoted cell proliferation and invasion. Mechanistically, miR-381-3p inhibits breast cancer progression and EMT by regulating the TGF-beta signaling via targeting Sox4 and Twist1.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Romain Larrue, Sandy Fellah, Nihad Boukrout, Corentin De Sousa, Julie Lemaire, Carolane Leboeuf, Marine Goujon, Michael Perrais, Bernard Mari, Christelle Cauffiez, Nicolas Pottier, Cynthia van der Hauwaert
Summary: Non-small cell lung cancer is characterized by poor prognosis due to low diagnosis efficiency and drug resistance. Targeting a specific small RNA (miR-92a-3p) may be an effective strategy to overcome chemotherapy resistance in cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Jiajing Wang, Na Sun, Yahan Ju, Ni Ni, Zhimin Tang, Dandan Zhang, Xiaochan Dai, Moxin Chen, Yiqi Wang, Ping Gu, Jing Ji
Summary: In this study, it was shown that miR-381-3p regulates the proliferation and differentiation of RPCs by targeting Hes1, providing an experimental basis for the potential therapeutic use of RPCs transplantation in treating retinal degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peiwen Zhang, Xinrong Li, Shunhua Zhang, Shuang Wu, Qian Xiao, Yang Gu, Xinyu Guo, Xutao Lin, Lei Chen, Ye Zhao, Lili Niu, Guoqing Tang, Yanzhi Jiang, Linyuan Shen, Li Zhu
Summary: The study showed that miR-370-3p reduces lipid accumulation by suppressing the expression of adipogenic markers, inhibits 3T3-L1 preadipocyte proliferation, and promotes differentiation. Additionally, the target gene of miR-370-3p, Mknk1, plays opposing roles in preadipocyte proliferation and differentiation.
Article
Biology
Lei Bi, Chunguang Zhang, Yuan Yao, Zhao He
Summary: The study revealed that circ-HIPK3 plays a role in oral squamous cell carcinoma by regulating YAP1 expression through sponging miR-381-3p, affecting cell proliferation, invasion, migration, apoptosis, and tumor growth.
JOURNAL OF BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hsin Hsu, I-Fan Liu, Hsuan-Fu Kuo, Chia-Yang Li, Wei-Shiung Lian, Chia-Yuan Chang, Yung-Hsiang Chen, Wei-Lun Liu, Chi-Yu Lu, Yu-Ru Liu, Tzu-Chieh Lin, Tsung-Ying Lee, Chi-Yuan Huang, Chong-Chao Hsieh, Po-Len Liu
Summary: miR-29a-3p exerts a direct anti-fibrotic effect on PAH-induced cardiac fibrosis by targeting THBS2 expression, with circulating levels of both miR-29a-3p and THBS2 correlating with PAH diagnosis and showing independent prognostic value.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Qiang Guo, Xiaoxiao Zhu, Ran Wei, Lin Zhao, Zhen Zhang, Xunqiang Yin, Yunhong Zhang, Chu Chu, Bin Wang, Xia Li
Summary: The study demonstrated that miR-130b-3p regulates the polarization of M1 macrophages by inhibiting IRF1, thus affecting inflammation. The miR-130b-3p/IRF1 pathway may be a potential target for regulating macrophage polarization.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vanessa Martinez-Rivera, Christian A. Cardenas-Monroy, Oliver Millan-Catalan, Jessica Gonzalez-Corona, N. Sofia Huerta-Pacheco, Antonio Martinez-Gutierrez, Alexa Villavicencio-Queijeiro, Carlos Pedraza-Lara, Alfredo Hidalgo-Miranda, Maria Elena Bravo-Gomez, Carlos Perez-Plasencia, Mariano Guardado-Estrada
Summary: The study revealed that miR-23b-3p and miR-381-3p may be involved in regulating gene expression related to autolysis processes, such as EPC1 gene, during the early PMI. The gene expression of miR-381-3p increased gradually throughout the first 24 hours of PMI, contrasting with miR-23b-3p.
Article
Neurosciences
Nikolaus R. Wagner, Ashis Sinha, Verl Siththanandan, Angelica M. Kowalchuk, Jessica L. MacDonald, Suzanne Tharin
Summary: This study reveals the important role of miR-409-3p in the development of callosal neurons, which controls intermediate progenitor cell numbers and callosal fate by directly repressing Cited2. The overexpression of miR-409-3p promotes the expression of corticospinal projection neurons and reduces the expression of callosal projection neurons.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biology
Yao Jiang, Jiali Liu, Huatao Liu, Wei Zhang, Xiaojin Li, Linqing Liu, Mei Zhou, Jieru Wang, Shiguang Su, Xiangdong Ding, Chonglong Wang
Summary: This study analyzed the gene expression profiles of low and high intramuscular fat (IMF) in Berkshire x Anqing Sixwhite crossbred pigs, and identified a ceRNA (lncRNA4789/miR-381-3p/FABP3) that showed differential expression in the longissimus dorsi tissue. Functional experiments revealed that miR-381-3p inhibits IMF deposition by suppressing preadipocyte differentiation and lipid droplet deposition, while lncRNA4789 rescues FABP3 expression by sponging miR-381-3p. This study provides insights into the molecular mechanisms underlying IMF deposition and potential molecular markers for improving pork quality.
Article
Environmental Sciences
Ping Deng, Miduo Tan, Wei Zhou, Chunhai Chen, Yu Xi, Peng Gao, Qinlong Ma, Yidan Liang, Mengyan Chen, Li Tian, Jia Xie, Mengyu Liu, Yan Luo, Yanqi Li, Lei Zhang, Liting Wang, Youlong Zeng, Huifeng Pi, Zhengping Yu, Zhou Zhou
Summary: The study found that BPA exposure significantly promoted the proliferation and migration of MCF-7 cells by affecting the cell cycle pathway. Screening differentially expressed genes identified PTTG1 and CDC20 as key targets associated with BPA-induced cell proliferation and migration.
Article
Endocrinology & Metabolism
Jing Zhang, Ying Hou, Lichao Sheng, Zhiyi Wang
Summary: This study reveals the regulatory networks involving miR-223-3p in endometriosis and finds that miR-223-3p inhibitor restrains the progression of ESCs by elevating FBXW7 expression.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
Zi-Bin Zhang, Liu-Lin Xiong, Lu-Lu Xue, Yan-Ping Deng, Ruo-Lan Du, Qiao Hu, Yang Xu, Si-Jin Yang, Ting-Hua Wang
Summary: The study identified the underlying mechanism of neonatal hypoxic-ischemic injury, and targeting the miR-127-3p to CISD1 signal could be regarded as a new therapeutic strategy for preventing and treating HI injury.
CELL DEATH & DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
Bolin Cai, Manting Ma, Zhen Zhou, Shaofen Kong, Jing Zhang, Xiquan Zhang, Qinghua Nie
Summary: This study identified a novel circRNA circPTPN4 and demonstrated its important role in chicken skeletal muscle development by promoting the proliferation and differentiation of myoblasts, suppressing mitochondrial biogenesis, and activating the fast-twitch muscle phenotype. circPTPN4 functions as a ceRNA that regulates NAMPT expression by sponging miR-499-3p, thus influencing AMPK signaling.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Immunology
Jinli Wang, Ruining Wang, Jiahui Yang, Xiaofan Yang, Shengfeng Hu, Hui Wang, Chaoying Zhou, Wenjing Xiong, Qian Wen, Li Ma
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Qian Wen, Shimeng Zhang, Xialin Du, Ruining Wang, Yanfen Li, Honglin Liu, Shengfeng Hu, Chaoying Zhou, Xinying Zhou, Li Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Immunology
Wenjing Xiong, Qian Wen, Xialin Du, Jinli Wang, Wenting He, Ruining Wang, Shengfeng Hu, Xinying Zhou, Jiahui Yang, Yuchi Gao, Li Ma
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Immunology
Wenting He, Shengfeng Hu, Xialin Du, Qian Wen, Xiao-Ping Zhong, Xinying Zhou, Chaoying Zhou, Wenjing Xiong, Yuchi Gao, Shimeng Zhang, Ruining Wang, Jiahui Yang, Li Ma
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Microbiology
Shengfeng Hu, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Xiaoxia Zhan, Wenting He, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Jiahui Yang, Wenjing Xiong, Ruining Wang, Yuchi Gao, Li Ma
Article
Immunology
Shengfeng Hu, Wenting He, Xialin Du, Yulan Huang, Yuling Fu, Yalong Yang, Chuxuan Hu, Silin Li, Qinshu Wang, Qian Wen, Xinying Zhou, Chaoying Zhou, Xiao-Ping Zhong, Li Ma
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Rui-Ning Wang, Qian Wen, Wen-Ting He, Jia-Hui Yang, Chao-Ying Zhou, Wen-Jing Xiong, Li Ma
MOLECULAR MEDICINE REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Xinying Zhou, Jiahui Yang, Zelin Zhang, Lijie Zhang, Bo Zhu, Linmiao Lie, Yubin Huang, Rui Ma, Chaoying Zhou, Shengfeng Hu, Qian Wen, Li Ma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Usman Hyder, Jennifer L. McCann, Jinli Wang, Victor Fung, Juan Bayo, Ivan D'Orso
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)