Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming

Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques ofApoE−/−MiceNovelty and Significance

(2016) Vincent Sarrazy et al.   CIRCULATION RESEARCH

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

(2016) Talya L. Dayton et al.   GENES & DEVELOPMENT

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

(2016) Tsuyoshi Shirai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Mode of Bioenergetic Metabolism during B Cell Differentiation in the Intestine Determines the Distinct Requirement for Vitamin B 1

(2015) Jun Kunisawa et al.   Cell Reports

No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis

(2015) Katharina Bluemlein et al.   Oncotarget

B Cells and Humoral Immunity in Atherosclerosis

(2014) Dimitrios Tsiantoulas et al.   CIRCULATION RESEARCH

Glucose-dependentde NovoLipogenesis in B Lymphocytes

(2014) Fay J. Dufort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

(2014) Tomohiro Nishizawa et al.   Cell Reports

Metabolic Reprograming in Macrophage Polarization

(2014) Silvia Galván-Peña et al.   Frontiers in Immunology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Pharmacological Properties of Shikonin – A Review of Literature since 2002

(2013) Isabel Andújar et al.   PLANTA MEDICA

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE−/− mice

(2012) Kongyang Ma et al.   CARDIOVASCULAR RESEARCH

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

B cell depletion reduces the development of atherosclerosis in mice

(2010) Hafid Ait-Oufella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

(2010) T. Kyaw et al.   JOURNAL OF IMMUNOLOGY

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE