ERβ-Dependent Direct Suppression of Human and Murine Th17 Cells and Treatment of Established Central Nervous System Autoimmunity by a Neurosteroid

ERβ in CD4+T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity

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Estradiol Inhibits Th17 Cell Differentiation through Inhibition ofRORγTTranscription by Recruiting the ERα/REA Complex to Estrogen Response Elements of theRORγTPromoter

(2015) Rong-Yi Chen et al.   JOURNAL OF IMMUNOLOGY

DHEA – a precursor of ERβ ligands

(2015) Margaret Warner et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

(2015) Nicola Gagliani et al.   NATURE

The prodrug DHED selectively delivers 17β-estradiol to the brain for treating estrogen-responsive disorders

(2015) Laszlo Prokai et al.   Science Translational Medicine

Osteopontin expression by CD103−dendritic cells drives intestinal inflammation

(2014) Evangelia Kourepini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis

(2014) Spencer M. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Main features of human T helper 17 cells

(2013) Francesco Annunziato et al.   Annals of the New York Academy of Sciences

The structural biology of oestrogen metabolism

(2013) Mark P. Thomas et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines

(2012) Jacques Banchereau et al.   NATURE IMMUNOLOGY

Impaired neurosteroid synthesis in multiple sclerosis

(2011) Farshid Noorbakhsh et al.   BRAIN

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

(2011) Kaoru Saijo et al.   CELL

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation

(2011) Ashutosh Chaudhry et al.   IMMUNITY

Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism

(2011) Atul Purohit et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neurosteroid Dehydroepiandrosterone Interacts with Nerve Growth Factor (NGF) Receptors, Preventing Neuronal Apoptosis

(2011) Iakovos Lazaridis et al.   PLOS BIOLOGY

Regulation of human Th9 differentiation by type I interferons and IL-21

(2010) Michael T Wong et al.   IMMUNOLOGY AND CELL BIOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis

(2010) Robert C Axtell et al.   NATURE MEDICINE

Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi

(2009) Vânia Brazão et al.   IMMUNOBIOLOGY

A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility

(2009) Alessandro Bonetti et al.   JOURNAL OF NEUROIMMUNOLOGY

Estrogen treatment in multiple sclerosis

(2009) Stefan M. Gold et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERα)

(2009) Stefan M Gold et al.   LABORATORY INVESTIGATION

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Tracing Functional Antigen-Specific CCR6+ Th17 Cells after Vaccination

(2008) Johann Pötzl et al.   PLoS One

Neurosteroids as modulators of neurogenesis and neuronal survival

(2008) Ioannis Charalampopoulos et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY