Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR

Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases

(2015) Juan Pablo Mackern-Oberti et al.   AUTOIMMUNITY REVIEWS

Novel diagnostic and therapeutic approaches for autoimmune diabetes — A prime time to treat insulitis as a disease

(2015) Juha Grönholm et al.   CLINICAL IMMUNOLOGY

Activation of benign autoimmunity as both tumor and autoimmune disease immunotherapy: A comprehensive review

(2014) Irun R. Cohen   JOURNAL OF AUTOIMMUNITY

Inefficient Translocation of Preproinsulin Contributes to Pancreatic β Cell Failure and Late-onset Diabetes

(2014) Huan Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Biomarkers for immune intervention trials in type 1 diabetes

(2013) Roberto Mallone et al.   CLINICAL IMMUNOLOGY

Antigen processing

(2013) Caetano Reis e Sousa et al.   CURRENT OPINION IN IMMUNOLOGY

 -Cells, Autoimmunity, and the Innate Immune System: "un Menage a Trois"?

(2013) B. O. Roep   DIABETES

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

(2013) M. van Lummel et al.   DIABETES

Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms

(2013) C. Nguyen et al.   DIABETES

Cutting Edge: Conditional MHC Class II Expression Reveals a Limited Role for B Cell Antigen Presentation in Primary and Secondary CD4 T Cell Responses

(2013) A. S. Archambault et al.   JOURNAL OF IMMUNOLOGY

The Effect of Proteasome Inhibition on the Generation of the Human Leukocyte Antigen (HLA) Peptidome

(2013) Elena Milner et al.   MOLECULAR & CELLULAR PROTEOMICS

ZnT8-Specific CD4+ T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy Adults

(2013) Daisuke Chujo et al.   PLoS One

Antigen Targets of Type 1 Diabetes Autoimmunity

(2013) B. O. Roep et al.   Cold Spring Harbor Perspectives in Medicine

CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity

(2012) J. R. F. Abreu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity

(2012) Robin R. Knight et al.   DIABETES

Immunological pathways to β-cell damage in Type 1 diabetes

(2012) M. Peakman   DIABETIC MEDICINE

CD4+T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring

(2012) Junbao Yang et al.   IMMUNOLOGY

Chemokine programming dendritic cell antigen response: part I - select chemokine programming of antigen uptake even after maturation

(2012) Jaehyung Park et al.   IMMUNOLOGY

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GPS-MBA: Computational Analysis of MHC Class II Epitopes in Type 1 Diabetes

(2012) Ruikun Cai et al.   PLoS One

Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative

(2011) E. A. James et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Humoral Autoimmunity against the Extracellular Domain of the Neuroendocrine Autoantigen IA-2 Heightens the Risk of Type 1 Diabetes

(2010) Michael P. Morran et al.   ENDOCRINOLOGY

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Prediction of HLA-DQ8 β cell peptidome using a computational program and its relationship to autoreactive T cells

(2009) Kuan Y. Chang et al.   INTERNATIONAL IMMUNOLOGY

Protease-resistant human GAD-derived altered peptide ligands decrease TNF-α and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus

(2009) Bernhard O. Boehm et al.   MOLECULAR IMMUNOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Glutamic Acid Decarboxylase-Derived Epitopes with Specific Domains Expand CD4+CD25+ Regulatory T Cells

(2009) Guojiang Chen et al.   PLoS One

Dendritic cells in islets of Langerhans constitutively present   cell-derived peptides bound to their class II MHC molecules

(2008) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA