Sirtuin 6 protects against hepatic fibrogenesis by suppressing the YAP and TAZ function

Loss of Proximal Tubular Sirtuin 6 Aggravates Unilateral Ureteral Obstruction-Induced Tubulointerstitial Inflammation and Fibrosis by Regulation of β-Catenin Acetylation

(2022) Jixiu Jin et al.   Cells

Signal transduction and molecular regulation in fatty liver disease

(2021) X Charlie Dong et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Liver knockout YAP gene improved insulin resistance-induced hepatic fibrosis

(2021) Yujiao Dai et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

(2020) Xiaobo Wang et al.   Cell Metabolism

Sirt6 alleviated liver fibrosis by deacetylating conserved lysine 54 on Smad2 in hepatic stellate cells

(2020) Jinhang Zhang et al.   HEPATOLOGY

YAP and TAZ Are Not Identical Twins

(2020) Francesca Reggiani et al.   TRENDS IN BIOCHEMICAL SCIENCES

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells

(2019) Hai-xia Yu et al.   MOLECULAR IMMUNOLOGY

p300 Acetyltransferase Is a Cytoplasm‐to‐Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β–Stimulated Hepatic Stellate Cells

(2019) Yuanguo Wang et al.   HEPATOLOGY

Downregulation of Hedgehog Ligands in Human Simple Steatosis May Protect Against Nonalcoholic Steatohepatitis: Is TAZ a Crucial Regulator?

(2019) Zohreh Khajehahmadi et al.   IUBMB LIFE

Role of the Hippo Pathway in Fibrosis and Cancer

(2019) Kim et al.   Cells

Sesn3 protects against diet-induced nonalcoholic steatohepatitis in mice via suppression of the TGFβ signal transduction

(2019) Menghao Huang et al.   HEPATOLOGY

Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury

(2019) Yuan Liu et al.   JOURNAL OF HEPATOLOGY

Hepatocyte Stress Increases Expression of YAP and TAZ in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

(2019) Meghan Mooring et al.   HEPATOLOGY

The deacetylase sirtuin 6 protects against kidney fibrosis by epigenetically blocking β-catenin target gene expression

(2019) Juan Cai et al.   KIDNEY INTERNATIONAL

Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells

(2018) Kuo Du et al.   GASTROENTEROLOGY

The Hippo Pathway: Biology and Pathophysiology

(2018) Shenghong Ma et al.   Annual Review of Biochemistry

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

(2016) Katherine Martin et al.   Nature Communications

ω-3 PUFAs ameliorate liver fibrosis and inhibit hepatic stellate cells proliferation and activation by promoting YAP/TAZ degradation

(2016) Kun Zhang et al.   Scientific Reports

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

Isolation and culture of hepatic stellate cells from mouse liver

(2014) Wenju Chang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

(2013) B Mao et al.   ONCOGENE

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response toSN2 Alkylating Agents

(2012) Shoji Hata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY