Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Quantitative pharmacokinetic analyses of anterior and posterior elimination routes of intravitreal anti-VEGF macromolecules using published human and rabbit data
Authors
Keywords
-
Journal
EXPERIMENTAL EYE RESEARCH
Volume 222, Issue -, Pages 109162
Publisher
Elsevier BV
Online
2022-06-26
DOI
10.1016/j.exer.2022.109162
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Intraocular Pharmacokinetics of 10-fold Intravitreal Ranibizumab Injection Dose in Rabbits
- (2020) Hyeong Min Kim et al. Translational Vision Science & Technology
- Comparative Safety of Bevacizumab, Ranibizumab, and Aflibercept for Treatment of Neovascular Age-Related Macular Degeneration (AMD): A Systematic Review and Network Meta-Analysis of Direct Comparative Studies
- (2020) Anna A. Plyukhova et al. Journal of Clinical Medicine
- Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies in rabbits
- (2020) David Bussing et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Extended Pharmacokinetic Model of the Intravitreal Injections of Macromolecules in Rabbits. Part 2: Parameter Estimation Based on Concentration Dynamics in the Vitreous, Retina, and Aqueous Humor
- (2020) Marko Lamminsalo et al. PHARMACEUTICAL RESEARCH
- Physiologically based ocular pharmacokinetic modeling using computational methods
- (2019) Paul J. Missel et al. DRUG DISCOVERY TODAY
- Ocular translational science: A review of development steps and paths
- (2018) Brenda K. Mann et al. ADVANCED DRUG DELIVERY REVIEWS
- Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways
- (2018) Marko Lamminsalo et al. PHARMACEUTICAL RESEARCH
- Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments
- (2018) Anna-Kaisa Rimpelä et al. Pharmaceutics
- Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model
- (2017) Laurence A. Hutton-Smith et al. MOLECULAR PHARMACEUTICS
- Pharmacokinetic aspects of retinal drug delivery
- (2017) Eva M. del Amo et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Recent perspectives on the delivery of biologics to back of the eye
- (2016) Mary Joseph et al. Expert Opinion on Drug Delivery
- A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration
- (2016) Laurence A. Hutton-Smith et al. MOLECULAR PHARMACEUTICS
- Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab
- (2016) Whitney Shatz et al. MOLECULAR PHARMACEUTICS
- Five-Year Outcomes with Anti–Vascular Endothelial Growth Factor Treatment of Neovascular Age-Related Macular Degeneration
- (2016) Maureen G. Maguire et al. OPHTHALMOLOGY
- A Meta-Analysis of Studies Evaluating Visual and Anatomical Outcomes in Patients with Treatment Resistant Neovascular Age-Related Macular Degeneration following Switching to Treatment with Aflibercept
- (2016) Sophie Seguin-Greenstein et al. Journal of Ophthalmology
- Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data
- (2015) Eva M. del Amo et al. EXPERIMENTAL EYE RESEARCH
- Clinical efficacy and mechanistic evaluation of aflibercept for proliferative diabetic retinopathy (acronym CLARITY): a multicentre phase IIb randomised active-controlled clinical trial
- (2015) Sobha Sivaprasad et al. BMJ Open
- Effect of Switching Therapy to Pegaptanib in Eyes With the Persistent Cases of Exudative Age-Related Macular Degeneration
- (2014) Chieko Shiragami et al. MEDICINE
- Pharmacokinetics, pharmacodynamics and pre-clinical characteristics of ophthalmic drugs that bind VEGF
- (2014) Michael W Stewart Expert Review of Clinical Pharmacology
- Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
- (2014) Wan Ling Wong et al. Lancet Global Health
- Simulating Intravitreal Injections in Anatomically Accurate Models for Rabbit, Monkey, and Human Eyes
- (2012) Paul J. Missel PHARMACEUTICAL RESEARCH
- INTRAOCULAR PHARMACOKINETICS AFTER A SINGLE INTRAVITREAL INJECTION OF 1.5 mg VERSUS 3.0 mg OF BEVACIZUMAB IN HUMANS
- (2011) Carsten H Meyer et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Characterizing molecular diffusion in the lens capsule
- (2009) Brian P. Danysh et al. MATRIX BIOLOGY
- Development of Translational Pharmacokinetic–Pharmacodynamic Models
- (2008) DE Mager et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started