Development of a physiologically-based pharmacokinetic model for ocular disposition of monoclonal antibodies in rabbits

Two-pore physiologically based pharmacokinetic model with de novo derived parameters for predicting plasma PK of different size protein therapeutics

(2019) Zhe Li et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model

(2017) Laurence A. Hutton-Smith et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetic aspects of retinal drug delivery

(2017) Eva M. del Amo et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Characterization of the interactions of rabbit neonatal Fc receptor (FcRn) with rabbit and human IgG isotypes

(2017) Bence Szikora et al.   PLoS One

Vascular Density in Retina and Choriocapillaris as Measured by Optical Coherence Tomography Angiography

(2016) Qian Wang et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Animal-to-Human Dose Translation of Obiltoxaximab for Treatment of Inhalational Anthrax Under the US FDA Animal Rule

(2016) CF Nagy et al.   CTS-Clinical and Translational Science

A Mechanistic Model of the Intravitreal Pharmacokinetics of Large Molecules and the Pharmacodynamic Suppression of Ocular Vascular Endothelial Growth Factor Levels by Ranibizumab in Patients with Neovascular Age-Related Macular Degeneration

(2016) Laurence A. Hutton-Smith et al.   MOLECULAR PHARMACEUTICS

Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans

(2016) Lisa M. Sweeney et al.   INHALATION TOXICOLOGY

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

(2015) Eva M. del Amo et al.   EXPERIMENTAL EYE RESEARCH

Ocular Adverse Events Associated with Antibody–Drug Conjugates in Human Clinical Trials

(2015) Joshua Seth Eaton et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Comparison of ocular tissue weights (volumes) and tissue collection techniques in commonly used preclinical animal species.

(2014) C STRUBLE et al.   ACTA OPHTHALMOLOGICA

Ophthalmic complications of targeted cancer therapy and recently recognized ophthalmic complications of traditional chemotherapy

(2014) Wajiha J. Kheir et al.   SURVEY OF OPHTHALMOLOGY

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Effect of Anthrax Immune Globulin on Response to BioThrax (Anthrax Vaccine Adsorbed) in New Zealand White Rabbits

(2013) Nina V. Malkevich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ocular side effects of biological agents in oncology: what should the clinician be aware of?

(2013) Tobias Hager et al.   OncoTargets and Therapy

A phase 1 study of weekly dosing of trastuzumab emtansine (T-DM1) in patients with advanced human epidermal growth factor 2-positive breast cancer

(2012) Muralidhar Beeram et al.   CANCER

Ocular Toxicity of Targeted Therapies

(2012) Daniel J. Renouf et al.   JOURNAL OF CLINICAL ONCOLOGY

Spectrum of ocular toxicities from epidermal growth factor receptor inhibitors and their intermediate-term follow-up: a five-year review

(2012) Durga S. Borkar et al.   SUPPORTIVE CARE IN CANCER

Trichomegaly and other external eye side effects associated with epidermal growth factor

(2011) Frederick T. Fraunfelder et al.   Cutaneous and Ocular Toxicology

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Phase II Study of the Antibody Drug Conjugate Trastuzumab-DM1 for the Treatment of Human Epidermal Growth Factor Receptor 2 (HER2) –Positive Breast Cancer After Prior HER2-Directed Therapy

(2010) Howard A. Burris et al.   JOURNAL OF CLINICAL ONCOLOGY

Physiologically based pharmacokinetic model for T84.66: A monoclonal anti-CEA antibody

(2009) Shweta R. Urva et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Safety Evaluation of Ocular Drug Delivery Formulations: Techniques and Practical Considerations

(2008) Brian G. Short   TOXICOLOGIC PATHOLOGY