Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

(2022) Yuto Unoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture

(2021) Nikos Kühl et al.   JOURNAL OF MEDICINAL CHEMISTRY

The spectrum between substrates and inhibitors: Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity

(2021) Tonko Dražić et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A short survey of Dengue protease inhibitor development in the past 6 years (2015-2020) with an emphasis on similarities between DENV and SARS-CoV-2 proteases

(2021) Sheikh Murtuja et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay

(2021) Tonko Dražić et al.   SLAS Discovery

Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease

(2021) Crystall Swarbrick et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

The SARS-CoV-2 outbreak: What we know

(2020) Di Wu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Conformational selection in the flaviviral NS2B-NS3 protease

(2020) Mira A.M. Behnam et al.   BIOCHIMIE

Design and discovery of boronic acid drugs

(2020) Jessica Plescia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

“Emergence of co-infection of COVID-19 and dengue: A serious public health threat ”

(2020) Arbab Saddique et al.   JOURNAL OF INFECTION

A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays

(2020) Nikos Kühl et al.   JOURNAL OF MEDICINAL CHEMISTRY

The SARS-CoV-2 main protease as drug target

(2020) Sven Ullrich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluating crisaborole as a treatment option for atopic dermatitis

(2019) Vignesh Ramachandran et al.   EXPERT OPINION ON PHARMACOTHERAPY

Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes

(2019) Tonko Dražić et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzoxaborole compounds for therapeutic uses: a patent review (2010- 2018)

(2018) Alessio Nocentini et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid

(2018) Ian W. Windsor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

(2016) Vincenzo Alterio et al.   CHEMICAL COMMUNICATIONS

Peptide–Boronic Acid Inhibitors of Flaviviral Proteases: Medicinal Chemistry and Structural Biology

(2016) Christoph Nitsche et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

(2016) Jian Lei et al.   SCIENCE

Synthesis and evaluation of functionalized benzoboroxoles as potential anti -tuberculosis agents

(2016) Mohammad A. Alam et al.   TETRAHEDRON

Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

(2015) Mira A. M. Behnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of functionalized aminobenzoboroxoles as potential anti -cancer agents

(2015) Pathi Suman et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62

(2015) Philippe Metz et al.   JOURNAL OF VIROLOGY

Biochemistry and Medicinal Chemistry of the Dengue Virus Protease

(2014) Christoph Nitsche et al.   CHEMICAL REVIEWS

Tavaborole: First Global Approval

(2014) Anthony Markham   DRUGS

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

A Convenient and Efficient Synthesis of Dipeptidyl Benzoxaboroles and Their Peptidomimetics

(2013) Zhengyan Fu et al.   SYNTHESIS-STUTTGART

Boron Containing Compounds as Protease Inhibitors

(2012) Reem Smoum et al.   CHEMICAL REVIEWS

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties

(2011) Xianfeng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease

(2010) Xianfeng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease

(2010) Charles Z. Ding et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Influence of the Substituents on the Structure and Properties of Benzoxaboroles

(2010) Agnieszka Adamczyk-Woźniak et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Dengue: a continuing global threat

(2010) Maria G. Guzman et al.   NATURE REVIEWS MICROBIOLOGY

Potent inhibitors of HCV-NS3 protease derived from boronic acids

(2008) Srikanth Venkatraman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Novel Design of Artificial Membrane for Improving the PAMPA Model

(2008) Xiaoxi Chen et al.   PHARMACEUTICAL RESEARCH