Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors

Small-molecule MDM2 inhibitors in clinical trials for cancer therapy

(2022) Shuai Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme

(2021) Simona Daniele et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators

(2021) Gehad Lotfy et al.   BIOORGANIC CHEMISTRY

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation

(2021) Yasmine M. Abdel Aziz et al.   Frontiers in Chemistry

Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction

(2019) Assem Barakat et al.   BIOORGANIC CHEMISTRY

Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes

(2019) Joerg Kallen et al.   ChemMedChem

An Update on MDMX and Dual MDM2/X Inhibitors

(2018) Margarida Espadinha et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis of new thiazolo-pyrrolidine–(spirooxindole) tethered to 3-acylindole as anticancer agents

(2018) Mohammad Shahidul Islam et al.   BIOORGANIC CHEMISTRY

In vitro targeting of colon cancer cells using spiropyrazoline oxindoles

(2017) Rute C. Nunes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development

(2017) Angelo Aguilar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas

(2016) Simona Daniele et al.   JOURNAL OF MEDICINAL CHEMISTRY

Long lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells

(2016) Simona Daniele et al.   Oncotarget

Pharmacological reactivation of p53 as a strategy to treat cancer

(2015) J. Zawacka-Pankau et al.   JOURNAL OF INTERNAL MEDICINE

Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines

(2014) Ângelo Monteiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2–p53 Interaction

(2014) Yosup Rew et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma

(2014) Simona Daniele et al.   Scientific Reports

Phosphine-Catalyzed Synthesis of 3,3-Spirocyclopenteneoxindoles from γ-Substituted Allenoates: Systematic Studies and Targeted Applications

(2013) Catherine Gomez et al.   JOURNAL OF ORGANIC CHEMISTRY

Conformer Generation with OMEGA: Learning from the Data Set and the Analysis of Failures

(2012) Paul C. D. Hawkins et al.   Journal of Chemical Information and Modeling

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

FRED Pose Prediction and Virtual Screening Accuracy

(2011) Mark McGann   Journal of Chemical Information and Modeling

SwissParam: A fast force field generation tool for small organic molecules

(2011) Vincent Zoete et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

(2010) Grzegorz M. Popowicz et al.   CELL CYCLE

The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform

(2010) Sunita J. Shukla et al.   DRUG DISCOVERY TODAY

Regiospecific Synthesis of Novel 6-Amino-5-hydroxypyridazin-3(2H)-ones

(2008) Peter Dragovich et al.   SYNTHESIS-STUTTGART