Article
Food Science & Technology
Lennie Cheung, Rickey Yada
Summary: The article provides an overview of studies using compounds to inhibit coronavirus infection and replication, and discusses the implications of these studies for future antiviral and bioactive food research.
CURRENT OPINION IN FOOD SCIENCE
(2022)
Article
Integrative & Complementary Medicine
Liang Hong, Min He, Shaoping Li, Jing Zhao
Summary: This study explored the potential anti-(mutant) SARS-CoV-2 and anti-inflammation compounds of LHQW against COVID-19, which can provide new ideas and valuable references for discovering active compounds in the treatment of COVID-19.
Article
Chemistry, Physical
Ola A. El-Gammal, Ashraf A. El-Bindary, Farid Sh Mohamed, Ghada N. Rezk, Mohamed A. El-Bindary
Summary: This study investigates the properties of a novel Schiff base and its complexes with Co(II), Ni(II), and Cu(II) metals using various analysis methods. The research covers structural characterization, thermodynamic properties, DNA binding, antioxidant activity, and antibacterial action. The potential of the compound in combating COVID-19 and prostate cancer is evaluated through its interaction with the SARS-CoV-2 main protease.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Cell Biology
Xingyue Qin, Chen Huang, Ka Wu, Yu Li, Xiao Liang, Min Su, Rong Li
Summary: This study aimed to uncover the pharmacological function and underlying mechanism of puerarin as a potential treatment for COVID-19 using network pharmacology and molecular docking. Puerarin was found to target key proteins involved in oxidative stress, inflammation, and apoptosis to exert its anti-COVID-19 effects. The results also indicated that puerarin may serve as a potential treatment for COVID-19 by targeting specific signaling pathways.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Premnath Dhanaraj, Indiraleka Muthiah, Mahtabin Rodela Rozbu, Samiha Nuzhat, Mosae Selvakumar Paulraj
Summary: The rapid spread of the new coronavirus (SARS-CoV-2) has created an urgent need to find a promising ligand for COVID-19 treatment. Symptoms of COVID-19 include dry cough, fever, and shortness of breath, with some patients experiencing anosmia and ageusia. Research suggests that SARS-CoV-2 may infect neurons in the nasal passage and disrupt the senses of smell and taste, highlighting the potential for developing drugs based on T2Rs to combat COVID-19.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Plant Sciences
Hanan Y. Aati, Ahmed Ismail, Mostafa E. Rateb, Asmaa M. AboulMagd, Hossam M. Hassan, Mona H. Hetta
Summary: COVID-19 is a disease caused by the coronavirus SARS-CoV-2 and became a pandemic in a critically short time. In this study, a metabolomics analysis of the Garcinia cambogia Roxb. fruit rind was conducted, leading to the isolation of eight known compounds. Among them, naringin showed potent antiviral activity and molecular docking studies revealed its interaction with the COVID-19 protease enzyme.
Article
Biochemistry & Molecular Biology
Mandeep Kaur, Hafiz Muzzammel Rehman, Gurmeet Kaur, Amandeep Kaur, Manisha Bansal
Summary: A new series of linker-based derivatives of non-steroidal anti-inflammatory drugs were synthesized and characterized. The study focused on understanding the switch in the anti-inflammatory and anticancer activity of compounds 8 and 10 through in-silico and in-vitro studies. The molecular docking study showed the importance of hetero atoms and proper alignment in the binding pocket for bioactivity. Compound 8 exhibited better inhibitory activity against the COX-2 target site, possibly due to the presence of 1,3-dicarbonyl interactions, whereas compound 10 showed increased potency towards anticancer activity. In-vitro assays confirmed the results obtained from the in-silico study.
BIOORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis Zagaliotis, Anthi Petrou, George A. Mystridis, Athina Geronikaki, Ioannis S. Vizirianakis, Thomas J. Walsh
Summary: The development of broad-spectrum antiviral agents is difficult, as the key molecules and pathways differ greatly between viruses. The COVID-19 pandemic has highlighted the limited effectiveness of current antiviral agents. Clinical protocols for COVID-19 treatment currently focus on inhibiting inflammation or the cytopathic effect of the virus. There is a need for expanded oral antiviral agents with dual antiviral and anti-inflammatory activity for early treatment of COVID-19 in high-risk patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Mohammed B. Alshammari, Mohamed Ramadan, Ashraf A. Aly, Essmat M. El-Sheref, Md Afroz Bakht, Mahmoud A. . A. . Ibrahim, Ahmed M. Shawky
Summary: A new series of synthesized N-substituted-2-quinolonylacetohydrazides were evaluated for their activity towards SARS-CoV-2, with their structures confirmed by NMR, mass, IR spectra, and elemental analysis. Molecular docking calculations showed that most of the compounds had good binding affinity to the SARS-CoV-2 main protease (M-pro) comparable to Remdesivir.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Nayim Sepay, Aishwarya Sekar, Umesh C. Halder, Abdullah Alarifi, Mohd Afzal
Summary: Traditional medicines containing natural products have shown potential in fighting against the COVID-19 virus, with certain natural products identified as potential candidates for drug development.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Faiza Qureshi, Muhammad Nawaz, Soleiman Hisaindee, Sarah Ameen Almofty, Mohammad Azam Ansari, Qazi Mohammad Sajid Jamal, Nisar Ullah, Muhammad Taha, Ohood Alshehri, Bader Huwaimel, Mohammed Khaled Bin Break
Summary: This study reported the microwave synthesis of seven unique pyrimidine anchored derivatives and their activities against cancer and COVID-19. Compound 6 exhibited the highest anticancer activity in both chemical analysis and cell experiments. In molecular docking on the main protease of SARS-CoV-2, derivative 6 had the highest binding energy score.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rachida Mansouri, Abdeslem Bouzina, Omar Sekiou, Zineb Aouf, Rachida Zerrouki, Malika Ibrahim-ouali, Nour Eddine Aouf
Summary: Novel pseudonucleosides containing cyclic sulfamide moiety and sulfamoyl beta-D-glucosamine derivative were synthesized and their structures were confirmed. Molecular docking study revealed the low binding affinity of the synthesized compounds compared to Beclabuvir, indicating their potential in inhibiting SARS-CoV-2. Molecular dynamics simulation showed the stability of the complex between SARS-CoV-2 M-pro and compound 7. The ADMET properties of the synthesized compounds were also studied.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Fengwen Huang, Chen Chen
Summary: This study evaluated the bioactivity of the thiol drug Bucillamine (BUC) as a potential drug for COVID-19 treatment using computational modeling strategies. The results propose that BUC can be a potential drug candidate against the COVID-19 disease progression.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Ju-Zhao Liu, Hong-Chang Lyu, Yu-Jie Fu, Qi Cui
Summary: With the constant mutations of COVID-19 virus, the emergence of the Omicron variant has posed challenges to global epidemic prevention. Research has identified active components in herbal plants that can block virus transmission, providing guidance for the modernization of Traditional Chinese medicine and prevention of COVID-19.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ranjan K. Mohapatra, Mohammad Azam, Pranab K. Mohapatra, Ashish K. Sarangi, Mohnad Abdalla, Lina Perekhoda, Oval Yadav, Saud I. Al-Resayes, Kim Jong-Doo, Kuldeep Dhama, Azaj Ansari, Veronique Seidel, Sarika Verma, Mukesh K. Raval
Summary: This study investigates the inhibitory potential of compounds against SARS-CoV-2 infection through computer simulations. The compounds were evaluated based on docking scores, ligand efficiency, and binding free energy, and their pharmacokinetic properties and electronic structures were analyzed. Compound-5 showed the best binding affinity against all targets, while compounds 1, 3, and 5 were found to be less toxic and suitable for oral consumption.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Physical
Ola A. El-Gammal, Ashraf A. El-Bindary, Farid Sh Mohamed, Ghada N. Rezk, Mohamed A. El-Bindary
Summary: This study investigates the properties of a novel Schiff base and its complexes with Co(II), Ni(II), and Cu(II) metals using various analysis methods. The research covers structural characterization, thermodynamic properties, DNA binding, antioxidant activity, and antibacterial action. The potential of the compound in combating COVID-19 and prostate cancer is evaluated through its interaction with the SARS-CoV-2 main protease.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Gamil A. A. S. AlHazmi, Khlood G. AbouMelha, Mohamed A. El-Desouky, Ashraf El-Bindary
Summary: Zirconium metal organic framework (Zr-MOF) was synthesized by hydrothermal method, and various spectroscopic methods were used for sample characterization. The adsorption of doxorubicin (DOX) onto Zr-MOF was studied. The effects of DOX concentration, contact time, solution pH, and temperature were investigated. The surface properties of Zr-MOF were determined by scanning electron microscopy (SEM). The adsorption efficiency of Zr-MOF for DOX was found to be higher at pH 6. The equilibrium isotherms and kinetic data were described using different adsorption models. The docking interactions between DOX and lung cancer and liver cancer receptors were evaluated.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Adel A. El-Zahhar, Abubakr M. Idris
Summary: This study successfully synthesized a titanium oxide-magnetite/chitosan nanocomposite and applied it for the adsorptive removal of naphthalene, a hazardous polycyclic aromatic hydrocarbon, from water. The optimized conditions for maximum removal efficiency and adsorption capacity were pH 7, adsorbent concentration 2 g/L, and contact time of 24 h. The experimental results showed multilayer adsorption and good stability of the nanocomposite against regeneration.
PETROLEUM CHEMISTRY
(2022)
Article
Chemistry, Applied
Mohamed A. El-Bindary, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: Metal-organic framework (MOF) hybrid materials, specifically Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF), have shown promising results in pH-responsive drug release and enhanced cytotoxicity against cancer cells. This simple one-pot approach could potentially serve as a multifunctional drug delivery vehicle for various applications, including cancer treatment. Further studies are needed to explore the potential of DOX@Zr-MOF in targeting specific cancer types and antimicrobial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Majed M. Alghamdi, Adel A. El-Zahhar, Norah M. Alshahrani
Summary: Thin-film composite nanofiltration membranes were prepared using interfacial polymerization. The presence of magnetite nanoparticles influenced the membrane surface charge and increased the rejections of Na2SO4 and NaCl. However, the pure water permeation flux decreased with increasing nanoparticle content. The steady-state flux and FRRs increased, indicating improved antifouling behavior and stability. These membranes have potential applications in water desalination and treatment.
Article
Chemistry, Analytical
Majed M. Alghamdi, Eman Y. Alhomod, Nasser S. Awwad, Abubakr M. Idris, Adel A. El-Zahhar
Summary: In this study, a cost-effective adsorbent utilizing Mn7+-doped Sorel cement (SC) was developed for the rapid removal of methylene blue (MB) dye from aqueous solutions. The modified adsorbent exhibited significantly improved adsorption efficiency compared to pure SC, with a small addition of 0.01 g of Mn7+ achieving 100% removal efficiency up to a dye concentration of 100 mg/L. The equilibrium data followed the Freundlich isotherm and the pseudo-second-order kinetic model, indicating the feasibility and regeneration efficiency of the adsorption process. The results suggest that the modified sorbent has the potential to be used as a fast method for the removal of MB dye from wastewater.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2022)
Article
Physics, Condensed Matter
Adel A. El-Zahhar, I. M. Ashraf, Abubakr M. Idris, Abdelrahman Zkria
Summary: Composite films of PVA/PbI2 were prepared using a low-cost casting process and their characteristics were analyzed. The results showed increased crystalline nature with higher PbI2 content and homogeneous distribution of PbI2 within the polymer. The optical parameters revealed that the composite films could be used in optoelectronic applications.
PHYSICA B-CONDENSED MATTER
(2022)
Article
Chemistry, Inorganic & Nuclear
M. G. El-Desouky, A. A. El-Bindary, M. A. M. El-Afify, N. Hassan
Summary: The global community is currently facing the COVID-19 pandemic, caused by the SARS-CoV-2 virus. Scientists are researching potential drug candidates by screening ligands and drugs for structure-based design and docking to the main viral protease. Additionally, complexes of Cu(II), Ni(II), Zn(II), and Mn(II) with a specific ligand were synthesized and characterized.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Mahmoud E. E. Awad, Amr M. M. Farrag, Ashraf A. A. El-Bindary, Mohamed A. A. El-Bindary, Hala A. A. Kiwaan
Summary: In this study, a simple technique for the production of TiO2-QDs-Kao photocatalyst was reported. The photocatalyst exhibited excellent degradation efficiency for RhB dye under visible light. The mechanism of photocatalytic degradation was based on the transport of electrons and holes. Additionally, the photocatalyst showed high stability and reusability.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Walied A. A. Mohamed, Waleed M. Saad, Farid Sh. Mohamed, Ashraf A. El-Bindary
Summary: Three types of titanium dioxide quantum dots (TQDs) samples were synthesized at low calcination temperatures using a modified precipitation method. The samples were characterized and evaluated for their photocatalytic activity and application in real industrial effluent treatment.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Doaa G. M. Ali, Ahmed M. A. El Naggar, Gh Eshaq, Ebaa A. El-Shamy, Nagla M. Khalil, Adel A. El-Zahhar, Sadek A. Sadeek
Summary: Globally, the refining of lubricating oils is mainly done through solvent or hydrotreatment refining, both of which have their drawbacks such as environmental emissions and high energy consumption. Therefore, adopting green chemistry principles in this field can help reduce hazardous emissions and energy use. This study introduces a new platform for refining lube oil base-stocks using membrane separation and nanotechnology, with the best performance observed with MgO and Al2O3 membranes.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Multidisciplinary Sciences
Ghada N. Rezk, Ola A. El -Gammal, Salhah H. Alrefaee, Ismail Althagafi, Ashraf A. El-Bindary, Mohamed A. El-Bindary
Summary: A hydrazone ligand was successfully created by combining hydrazide with 2-Acetylpyridine. Copper (II) hydrazone complexes were synthesized using various copper (II) salts and studied using analytical techniques. The complexes exhibited tridentate behavior and octahedral geometries. Their properties were analyzed through computational calculations and experimental assays, revealing potential antimicrobial and antioxidant effects.
Article
Chemistry, Multidisciplinary
Marzouk Adel, Ahmed M. A. El Naggar, Ahmed Bakry, Maher H. Hilal, Adel A. El-Zahhar, Mohamed H. Taha, A. Marey
Summary: This study presents a novel adsorbent for the removal of dye and heavy metal contaminants from wastewater, using a composite fabricated by doping polystyrene with nanoparticles of cobalt hydroxide. The composite exhibited high adsorption capacities for both methylene blue dye and Fe(iii) ions, attributed to the presence of organic and inorganic functional groups in its structure. Kinetic, isotherm, and thermodynamic studies confirmed the feasibility, spontaneity, physisorption nature, and endothermicity of the adsorption process.
Article
Chemistry, Multidisciplinary
Mohamed El Saied, Ahmed O. Abo El Naga, Adel A. El-Zahhar, Gamil A. A. M. Al-Hazmi, Ahmed M. A. El Naggar, Fathy Y. El Kady
Summary: This study focuses on the synthesis of a novel composite membrane for the separation of high-purity hydrogen from gas mixtures. The composite membrane, made of activated carbon supported nickel nanoparticles, shows efficient hydrogen separation with high hydrogen flux and selectivity, as well as good hydrogen permeability.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
A. Marey, Marzouk Adel, Ahmed M. A. El Naggar, Adel A. El-Zahhar, Mohamed H. Taha
Summary: In this research, a new composite structure was developed and used as an absorbent for purifying wastewater from dye contaminants. The composite showed promising results in removal of methylene blue dye, thanks to its high adsorption capacity and stability.
DALTON TRANSACTIONS
(2023)