Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1230, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2020.129649
Keywords
Quinolone; N-substituted-2-quinolonylacetohydrazides; Nmr; Remdesivir; Molecular docking
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Funding
- Deanship of Scientific Research at Prince Sattam Bin Abdulaziz University [No10302/1/2019]
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A new series of synthesized N-substituted-2-quinolonylacetohydrazides were evaluated for their activity towards SARS-CoV-2, with their structures confirmed by NMR, mass, IR spectra, and elemental analysis. Molecular docking calculations showed that most of the compounds had good binding affinity to the SARS-CoV-2 main protease (M-pro) comparable to Remdesivir.
We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M-pro) comparable to Remdesivir. (C) 2020 Elsevier B.V. All rights reserved.
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