Article
Cell Biology
Huijuan Dai, Xiaonan Sheng, Yaohui Wang, Liheng Zhou, Yanping Lin, Yueyao Du, Fan Yang, Rui Sha, Jing Peng, Linli Yao, Wenjin Yin, Jinsong Lu
Summary: The study revealed that high HIF1a expression leads to lower pathological complete response and worse prognosis in breast cancer patients receiving taxane-based neoadjuvant therapy. HIF1a participates in interleukin 17 signaling pathway, affecting the sensitivity of paclitaxel to cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Mark S. Filla, Kristy K. Meyer, Jennifer A. Faralli, Donna M. Peters
Summary: Studies indicate that activation of αvβ3 integrin signaling may significantly impact TM cell function and POAG pathogenesis; overexpression of CA-αvβ3 integrin leads to significant differential gene expression involving multiple signaling pathways.
Article
Cell Biology
Sayako Katada, Jun Takouda, Takumi Nakagawa, Mizuki Honda, Katsuhide Igarashi, Takuya Imamura, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, Kinichi Nakashima
Summary: This study reveals a sophisticated regulation of NPC fate change during cortical development, where the interplay between cell-extrinsic cues and -intrinsic epigenetic programs plays a critical role. Smads, downstream transcription factors from BMP signaling, target different genomic regions in neurogenic and gliogenic NPCs, highlighting the importance of their role in regulating NPC properties.
GENES & DEVELOPMENT
(2021)
Review
Immunology
Jinguo Zhang, Shuaikang Pan, Chen Jian, Li Hao, Jie Dong, Qingqing Sun, Hongwei Jin, Xinghua Han
Summary: Breast cancer is the most common malignancy among females, and chemotherapy drugs have been the mainstay of treatment. The advent of immunotherapy has provided new hope for breast cancer treatment. Chemotherapy drugs have shown to stimulate the immune system in multiple ways, including inducing immunogenic cell death and activating immune effector cells while depleting immunosuppressive cells. This review summarizes recent clinical trials on the combination of chemotherapy and immunotherapy in breast cancer and discusses the molecular mechanisms of the immunostimulatory properties of chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Plant Sciences
Kevin Daniel, Sjon Hartman
Summary: Plant submergence is a major abiotic stress that can be mitigated by changes in root growth behavior and adaptation to low oxygen conditions. Ethylene and hypoxia signaling play important roles in regulating these adaptive root growth responses. Future research should focus on more natural experimental designs to better understand how plants respond to and survive waterlogging.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Microbiology
Kshitij Tandon, Yu-Jing Chiou, Sheng-Ping Yu, Hernyi Justin Hsieh, Chih-Ying Lu, Ming-Tsung Hsu, Pei-Wen Chiang, Hsing-Ju Chen, Naohisa Wada, Sen-Lin Tang
Summary: This study aims to investigate the differential ability of different Endozoicomonas species to respond to environmental changes. Using a combination of metabarcoding, genomics, and comparative genomics approaches, the study found that different dominant Endozoicomonas species existed in coral colonies separated by a small distance, including a newly discovered species. Furthermore, these dominant Endozoicomonas species exhibited different potentials to scavenge reactive oxygen species, indicating differences in their response to the environment.
Article
Neurosciences
Kevin Bayingana, Danielle Ireland, Elizabeth Rosenthal, Christina Rabeler, Eva-Maria S. Collins
Summary: There is a lack of data on the effects of chronic exposure to common drugs and stimulants on the developing nervous system. Freshwater planarians provide a useful invertebrate model for studying the effects of these compounds. In this study, ten common drugs and stimulants were tested on planarians, with fluoxetine and sertraline showing the most potent lethality. These results highlight the need for better evaluation of the safety of these drugs on the developing nervous system.
NEUROTOXICOLOGY AND TERATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sina Sender, Anett Sekora, Simon Villa Perez, Oleksandra Chabanovska, Annegret Becker, Anaclet Ngezahayo, Christian Junghanss, Hugo Murua Escobar
Summary: In this study, the SYK inhibitor entospletinib was evaluated in pre- and pro-B-ALL cell lines, showing significant anti-proliferative and pro-apoptotic effects in the inhibitor-sensitive cell lines and modulation of vital downstream effector proteins. The research suggests that SYK could be a potential target structure in a subset of pro-B-ALLs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Juanjuan Li, Chunai Gong, Xinlu Chen, Huanhuan Guo, Zongguang Tai, Nan Ding, Shen Gao, Yuan Gao
Summary: The multifunctional biomimetic nanodelivery system showed antitumor efficacy in vivo and in vitro, suggesting its potential for the treatment of breast cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Zuen Ren, Huizhi Liang, Phillip M. Galbo, Malindrie Dharmaratne, Ameya S. Kulkarni, Atefeh Taherian Fard, Marie Louise Aoun, Nuria Martinez-Lopez, Kimita Suyama, Outhiriaradjou Benard, Wei Zheng, Yang Liu, Joseph Albanese, Deyou Zheng, Jessica C. Mar, Rajat Singh, Michael B. Prystowsky, Larry Norton, Rachel B. Hazan
Summary: In breast cancer, the loss of GPx2 leads to redox imbalance, promoting malignant progression and correlating with key processes such as tumor angiogenesis and metabolic modulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Vincenzo Nassisi, Aurora Mazzei, Gianmarco Del Vecchio, Antonio Calisi, Luciano Velardi, Pietro Alifano, Tiziano Verri
Summary: In this experiment, groups of zebrafish embryos were exposed to radiations of different frequencies and intensities using new prototype devices. The radiations included static, extremely low-frequency, low-frequency, very-high-frequency, and ultra-high-frequency fields. The exposure led to alterations in body pigmentation of the zebrafish embryos and larvae. These findings contribute to understanding the effects of magnetic radiation on living organisms.
APPLIED SCIENCES-BASEL
(2023)
Article
Neurosciences
Cesar Adolfo Sanchez Trivino, Maria Paula Landinez, Sara Duran, Maria del Pilar Gomez, Enrico Nasi
Summary: This study investigated the effects of acute lithium exposure on cellular calcium mobilization and phospholipase C (PLC)-dependent membrane conductance. The results showed that lithium enhanced calcium mobilization and upregulated muscarinic membrane currents in cellular responses. Furthermore, the site of action for lithium effects was identified as the interaction between G protein and PLC-beta.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Melissa Newton, Savannah L. Cookson, Mark D'Esposito, Andrew S. Kayser
Summary: The study indicates that subregions within the intraparietal sulcus (IPS) exhibit activity responsive to abstract decision-making, and it suggests that IPS may be organized into frontoparietal subnetworks that support hierarchical cognitive control.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yunfeng Yan, Xiaofei Huang, Yao Zhou, Jingyi Li, Feiyun Liu, Xueying Li, Xiaotao Hu, Jing Wang, Lingyan Guo, Renning Liu, Naoki Takaya, Shengmin Zhou
Summary: In Aspergillus nidulans, the peroxiredoxin (PrxA) plays a crucial role in protecting dormant conidia against high levels of H2O2, while catalase (CatB) becomes the main antioxidant during the mature hyphae stage. CatB needs to be secreted to function, and this process is limited to the mature hyphae stage.
Article
Biochemistry & Molecular Biology
Ines Moniz, Joao Ramalho-Santos, Ana F. Branco
Summary: This study demonstrates that different oxygen tensions have distinct effects on umbilical cord-mesenchymal stem cells (UC-MSCs), including changes in proliferation and metabolism. The use of CoCl2 as a substitute for hypoxic chambers yields different metabolic effects compared to gas-based strategies. Severe hypoxia modulates survival-related mechanisms through different mTOR complexes. This research provides valuable insights into the establishment of a hypoxia model for UC-MSCs and how different strategies for modulating hypoxia may impact experimental outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Jiyang Yu, Jose Silva, Andrea Califano
Article
Cell Biology
Ruth Rodriguez-Barrueco, Jiyang Yu, Laura P. Saucedo-Cuevas, Mireia Olivan, David Llobet-Navas, Preeti Putcha, Veronica Castro, Eva M. Murga-Penas, Ana Collazo-Lorduy, Mireia Castillo-Martin, Mariano Alvarez, Carlos Cordon-Cardo, Kevin Kalinsky, Matthew Maurer, Andrea Califano, Jose M. Silva
GENES & DEVELOPMENT
(2015)
Article
Oncology
V. Tosello, F. Bordin, J. Yu, V. Agnusdei, S. Indraccolo, G. Basso, A. Amadori, E. Piovan
Article
Oncology
Mai Sato, Ruth Rodriguez-Barrueco, Jiyang Yu, Catherine Do, Jose M. Silva, Jean Gautier
Article
Biotechnology & Applied Microbiology
Jiyang Yu, Preeti Putcha, Jose M. Silva
BIOMED RESEARCH INTERNATIONAL
(2015)
Meeting Abstract
Oncology
J. Silva, R. Rodriguez-Barrueco, J. Yu, K. Kalinsky, M. Maurer, A. Califano
Article
Oncology
Valeria Tosello, Valentina Saccomani, Jiyang Yu, Fulvio Bordin, Alberto Amadori, Erich Piovan
Article
Cell Biology
Ruth Rodriguez-Barrueco, Erin A. Nekritz, Francois Bertucci, Jiyang Yu, Felix Sanchez-Garcia, Tizita Z. Zeleke, Andrej Gorbatenko, Daniel Birnbaum, Elena Ezhkova, Carlos Cordon-Cardo, Pascal Finetti, David Llobet-Navas, Jose M. Silva
GENES & DEVELOPMENT
(2017)
Article
Oncology
Presha Rajbhandari, Gonzalo Lopez, Claudia Capdevila, Beatrice Salvatori, Jiyang Yu, Ruth Rodriguez-Barrueco, Daniel Martinez, Mark Yarmarkovich, Nina Weichert-Leahey, Brian J. Abraham, Mariano J. Alvarez, Archana Iyer, Jo Lynne Harenza, Derek Oldridge, Katleen De Preter, Jan Koster, Shahab Asgharzadeh, Robert C. Seeger, Jun S. Wei, Javed Khan, Jo Vandesompele, Pieter Mestdagh, Rogier Versteeg, A. Thomas Look, Richard A. Young, Antonio Iavarone, Anna Lasorella, Jose M. Silva, John M. Maris, Andrea Califano
Article
Oncology
Erich Piovan, Jiyang Yu, Valeria Tosello, Daniel Herranz, Alberto Ambesi-Impiombato, Ana Carolina Da Silva, Marta Sanchez-Martin, Arianne Perez-Garcia, Isaura Rigo, Mireia Castillo, Stefano Indraccolo, Justin R. Cross, Elisa de Stanchina, Elisabeth Paietta, Janis Racevskis, Jacob M. Rowe, Martin S. Tallman, Giuseppe Basso, Jules P. Meijerink, Carlos Cordon-Cardo, Andrea Califano, Adolfo A. Ferrando
Article
Multidisciplinary Sciences
Xingrong Du, Jing Wen, Yanyan Wang, Peer W. F. Karmaus, Alireza Khatamian, Haiyan Tan, Yuxin Li, Cliff Guy, Thanh-Long M. Nguyen, Yogesh Dhungana, Geoffrey Neale, Junmin Peng, Jiyang Yu, Hongbo Chi
Correction
Oncology
Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, Francois Bertucci, Mary L. Alpaugh, Andrea Califano, Jose Silva
BREAST CANCER RESEARCH
(2017)
Meeting Abstract
Hematology
V. Tosello, V. Saccomani, J. Yu, F. Bordin, A. Amadori, E. Piovan
Article
Oncology
Preeti Putcha, Jiyang Yu, Ruth Rodriguez-Barrueco, Laura Saucedo-Cuevas, Patricia Villagrasa, Eva Murga-Penas, Steven N. Quayle, Min Yang, Veronica Castro, David Llobet-Navas, Daniel Birnbaum, Pascal Finetti, Wendy A. Woodward, Franois Bertucci, Mary L. Alpaugh, Andrea Califano, Jose Silva
BREAST CANCER RESEARCH
(2015)