miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas

(2016) Saya H. Ebbesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-424(322) reverses chemoresistance via T-cell immune response activation by blocking the PD-L1 immune checkpoint

(2016) Shaohua Xu et al.   Nature Communications

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

(2014) Helen King et al.   CANCER TREATMENT REVIEWS

X chromosome inactivation: recent advances and a look forward

(2014) Sharon F Briggs et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland

(2014) D. Llobet-Navas et al.   GENES & DEVELOPMENT

The MicroRNA 424/503 Cluster Reduces CDC25A Expression during Cell Cycle Arrest Imposed by Transforming Growth Factor   in Mammary Epithelial Cells

(2014) D. Llobet-Navas et al.   MOLECULAR AND CELLULAR BIOLOGY

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization

(2014) Timothy J. Sargeant et al.   NATURE CELL BIOLOGY

MicroRNA-503 Acts as a Tumor Suppressor in Osteosarcoma by Targeting L1CAM

(2014) Yang Chong et al.   PLoS One

Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer

(2013) François Vaillant et al.   CANCER CELL

Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice

(2013) J. Usary et al.   CLINICAL CANCER RESEARCH

Targeted Approaches to Triple-Negative Breast Cancer: Current Practice and Future Directions

(2013) A. Brunello et al.   CURRENT MEDICINAL CHEMISTRY

Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response

(2013) Lára Hannesdóttir et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNA-503 suppresses proliferation and cell-cycle progression of endometrioid endometrial cancer by negatively regulating cyclin D1

(2013) Yan-Ying Xu et al.   FEBS Journal

IGF-1R as an anti-cancer target--trials and tribulations

(2013) Helen X. Chen et al.   Chinese Journal of Cancer

Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages

(2012) A. P. Hutchins et al.   BLOOD

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

(2012)   LANCET ONCOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer

(2012) J Xu et al.   ONCOGENE

BCL-2 Family of Proteins and Mammary Cellular Fate

(2012) M. Colitti   ANATOMIA HISTOLOGIA EMBRYOLOGIA

Mammary gland development

(2012) Hector Macias et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Trastuzumab: Updated Mechanisms of Action and Resistance in Breast Cancer

(2012) Thuy Vu et al.   Frontiers in Oncology

Dual IGF-1R/InsR Inhibitor BMS-754807 Synergizes with Hormonal Agents in Treatment of Estrogen-Dependent Breast Cancer

(2011) X. Hou et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution

(2011) J. O'Brien et al.   DEVELOPMENT

Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review

(2011) Naval Bajwa et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

(2011) Andrew W. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes

(2011) Olivia S. Rissland et al.   MOLECULAR CELL

Stat3 controls lysosomal-mediated cell death in vivo

(2011) Peter A. Kreuzaler et al.   NATURE CELL BIOLOGY

BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

(2010) S-J Dawson et al.   BRITISH JOURNAL OF CANCER

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax

(2010) Edmund B. Rucker et al.   GENESIS

Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-α isoforms and promotes angiogenesis

(2010) Goutam Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases

(2010) John R. Finnerty et al.   JOURNAL OF MOLECULAR BIOLOGY

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy

(2010) Taiji Nakashima et al.   PLoS One

Triple-negative breast cancer--current status and future directions

(2009) O. Gluz et al.   ANNALS OF ONCOLOGY

miR-15a and miR-16-1 in cancer: discovery, function and future perspectives

(2009) R I Aqeilan et al.   CELL DEATH AND DIFFERENTIATION

Mammary Involution and Breast Cancer Risk: Transgenic Models and Clinical Studies

(2009) Derek C. Radisky et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Resistance to chemotherapy: new treatments and novel insights into an old problem

(2008) S Raguz et al.   BRITISH JOURNAL OF CANCER

TGF-β promotes cell death and suppresses lactation during the second stage of mammary involution

(2008) Brian Bierie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Dual Role for Oncostatin M Signaling in the Differentiation and Death of Mammary Epithelial Cellsin Vivo

(2008) Paul G. Tiffen et al.   MOLECULAR ENDOCRINOLOGY

miR-16 family induces cell cycle arrest by regulating multiple cell cycle genes

(2008) Q. Liu et al.   NUCLEIC ACIDS RESEARCH