A positive feedback loop involving the Wnt/β-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subpopulation in ALK-positive anaplastic large cell lymphoma

Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling

(2015) Vincenzo Giambra et al.   BLOOD

Wnt/ -Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells

(2015) G.-B. Jang et al.   CANCER RESEARCH

Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway

(2015) Yi Zhang et al.   Molecular Cancer

C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells

(2015) Kelvin Y. Kwan et al.   Stem Cell Reports

Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors

(2015) Zhenhua Yang et al.   PLoS One

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5

(2015) Huabo Wang et al.   Oncotarget

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Essential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma

(2014) Andre Weilemann et al.   BLOOD

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism

(2014) H. Akita et al.   CANCER RESEARCH

Diminished WNT ->  -catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors

(2014) J. Juan et al.   GENES & DEVELOPMENT

Anaplastic large cell lymphoma-propagating cells are detectable by side population analysis and possess an expression profile reflective of a primitive origin

(2014) N Moti et al.   ONCOGENE

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

(2014) R Santini et al.   ONCOGENE

VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2

(2014) D Zhao et al.   ONCOGENE

Inhibition of c-Myc Overcomes Cytotoxic Drug Resistance in Acute Myeloid Leukemia Cells by Promoting Differentiation

(2014) Xiao-Na Pan et al.   PLoS One

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network

(2013) Xuefei Li et al.   CANCER LETTERS

Sox2 promotes tamoxifen resistance in breast cancer cells

(2013) Marco Piva et al.   EMBO Molecular Medicine

Myc is required for β-catenin-mediated mammary stem cell amplification and tumorigenesis

(2013) Mejdi Moumen et al.   Molecular Cancer

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Roles for MYC in the Establishment and Maintenance of Pluripotency

(2013) J. Chappell et al.   Cold Spring Harbor Perspectives in Medicine

Wnt/β-Catenin Signaling Pathway Upregulates c-Myc Expression to Promote Cell Proliferation of P19 Teratocarcinoma Cells

(2012) Shuai Zhang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

SOX2 Gene Regulates the Transcriptional Network of Oncogenes and Affects Tumorigenesis of Human Lung Cancer Cells

(2012) Si Chen et al.   PLoS One

Aberrant expression and biological significance of Sox2, an embryonic stem cell transcriptional factor, in ALK-positive anaplastic large cell lymphoma

(2012) P Gelebart et al.   Blood Cancer Journal

NPM-ALK signals through glycogen synthase kinase 3β to promote oncogenesis

(2011) S R P McDonnell et al.   ONCOGENE

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

CD133 Positive Embryonal Rhabdomyosarcoma Stem-Like Cell Population Is Enriched in Rhabdospheres

(2011) Dagmar Walter et al.   PLoS One

Molecular characterisation of side population cells with cancer stem cell-like characteristics in small-cell lung cancer

(2010) C D Salcido et al.   BRITISH JOURNAL OF CANCER

 -catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

(2010) M. Anand et al.   HAEMATOLOGICA

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma

(2008) P. Gelebart et al.   BLOOD

The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer

(2008) Yupeng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells

(2008) Jialiang Wang et al.   PLoS One