Flavone-1,2,3-triazole derivatives as potential α-glucosidase inhibitors: Synthesis, enzyme inhibition, kinetic analysis and molecular docking study

A review on synthesis, mechanism of action, and structure-activity relationships of 1,2,3-triazole-based α-glucosidase inhibitors as promising anti-diabetic agents

(2022) Zari Fallah et al.   JOURNAL OF MOLECULAR STRUCTURE

Coumarin-1,2,3-triazole Hybrid Molecules: An Emerging Scaffold for Combating Drug Resistance

(2021) Harish C. Upadhyay   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synthesis, in vitro and computational studies of novel glycosyl-1, 2, 3-1H-triazolyl methyl benzamide derivatives as potential α-glucosidase inhibitory activity

(2021) Akhilesh Kumar Shukla et al.   BIOORGANIC CHEMISTRY

2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors

(2021) Ya-Sheng Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications

(2021) Anand K. Agrahari et al.   CHEMICAL REVIEWS

Recent progress on 1H-1,2,3-triazoles as potential antifungal agents

(2021) Nisha Poonia et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Progress in the Synthesis of Fused 1,2,3‐Triazoles

(2021) Hariom Kumar et al.   ChemistrySelect

Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-d-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase

(2021) Jaggaiah N. Gorantla et al.   ACS Omega

Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes

(2020) Tania Luthra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular docking, α-glucosidase inhibition, and antioxidant activity studies of novel benzimidazole derivatives

(2020) Gagandeep Singh et al.   MEDICINAL CHEMISTRY RESEARCH

1,2,3‐Triazole hybrids with anti‐HIV‐1 activity

(2020) Lian‐Shun Feng et al.   ARCHIV DER PHARMAZIE

Synthesis, characterization, α-glucosidase inhibition and molecular modeling studies of some pyrazoline-1H-1,2,3-triazole hybrids

(2020) Lokesh Kumar et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis, in vitro and in silico studies of naphto-1,3-oxazin-3(2H)-one derivatives as promising inhibitors of cholinesterase and α-glucosidase

(2020) Khawla Boudebbous et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview

(2019) Manoj Dhameja et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biscoumarin-1,2,3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studies

(2019) Mohammad Sadegh Asgari et al.   BIOORGANIC CHEMISTRY

Heterocycles in Medicinal Chemistry

(2019) Josef Jampilek   MOLECULES

Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries

(2019) Lanlan Jing et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of benzotriazoles derivatives and their dual potential as α-amylase and α-glucosidase inhibitors in vitro: Structure-activity relationship, molecular docking, and kinetic studies

(2019) Shehryar Hameed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Advancements in 1,4-Disubstituted 1H-1,2,3-Triazoles as Potential Anticancer Agents

(2018) Kashmiri Lal et al.   Anti-Cancer Agents in Medicinal Chemistry

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

(2018) N.H. Cho et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Current anti-diabetic agents and their molecular targets: A review

(2018) Nagaraju Kerru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and enzyme inhibitory kinetics of some novel 3-(substituted benzoyl)-2-thioxoimidazolidin-4-one derivatives as α-glucosidase/α-amylase inhibitors

(2018) Rabia Qamar et al.   MEDICINAL CHEMISTRY RESEARCH

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

(2018) Clementina M.M. Santos et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

α-Glucosidase inhibition activity and in silico study of 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one, a synthetic derivative of flavone

(2018) Surya N. Meena et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 3-acyloxyxanthone derivatives as α-glucosidase inhibitors: A further insight into the 3-substituents’ effect

(2016) Gai-Li Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 2,4,5-triarylimidazole–1,2,3-triazole derivatives via click chemistry as α-glucosidase inhibitors

(2016) Guangcheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cu-Catalyzed Click Reaction in Carbohydrate Chemistry

(2016) Vinod K. Tiwari et al.   CHEMICAL REVIEWS

Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors

(2016) Mina Saeedi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα

(2016) Garima Priyadarshani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multicomponent Synthesis and Evaluation of New 1,2,3-Triazole Derivatives of Dihydropyrimidinones as Acidic Corrosion Inhibitors for Steel

(2016) Rodrigo González-Olvera et al.   MOLECULES

Synthesis,In vitroand Docking Studies of New Flavone Ethers asα-Glucosidase Inhibitors

(2015) Syahrul Imran et al.   Chemical Biology & Drug Design

Antioxidant activity and inhibition of α-glucosidase by hydroxyl-functionalized 2-arylbenzo[b]furans

(2015) Jung-Feng Hsieh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel flavone hydrazones: In-vitro evaluation of α-glucosidase inhibition, QSAR analysis and docking studies

(2015) Syahrul Imran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

(2015) Usman Ghani   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Flavones: An important scaffold for medicinal chemistry

(2014) Manjinder Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome

(2013) Ronald Goldenberg et al.   Canadian Journal of Diabetes

Chemistry of biologically important flavones

(2012) Alok K. Verma et al.   TETRAHEDRON

Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose

(2010) Keizo Yamamoto et al.   FEBS Journal

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Type 2 Diabetes and Oral Antihyperglycemic Drugs

(2008) Mitchell Avery et al.   CURRENT MEDICINAL CHEMISTRY