Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

(2011) W. Patrick Walters et al.   JOURNAL OF MEDICINAL CHEMISTRY

Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

(2011) Eric Marsault et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

(2011) Alexander Alex et al.   MedChemComm

N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies

(2010) Pierre L. Beaulieu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase

(2010) Frank Narjes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ruthenium-Based Heterocyclic Carbene-Coordinated Olefin Metathesis Catalysts†

(2009) Georgios C. Vougioukalakis et al.   CHEMICAL REVIEWS

Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase

(2008) Jörg Habermann et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase

(2008) Ian Stansfield et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolic activation of carboxylic acids

(2008) Christian Skonberg et al.   Expert Opinion on Drug Metabolism & Toxicology

Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease

(2008) Nigel J. Liverton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY