Modulating the Siah2-PHD3-HIF1α axis and/or autophagy potentially retard colon cancer proliferation possibly, due to the damping of colon cancer stem cells

An overview on the chemistry, pharmacology and anticancer properties of tetrandrine and fangchinoline (alkaloids) from Stephania tetrandra roots

(2021) Eric Wei Chiang Chan et al.   Journal of Integrative Medicine-JIM

Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells

(2021) Ahmad Besaratinia et al.   DNA REPAIR

Crosstalk between autophagy and metabolic regulation of cancer stem cells

(2020) Mouradi El Hout et al.   Molecular Cancer

Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5

(2020) Xing Feng et al.   Autophagy

A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

(2020) Herbert J. Zeh et al.   CLINICAL CANCER RESEARCH

Biochemical Markers of Colorectal Cancer – Present and Future

(2020) Wojciech Jelski et al.   Cancer Management and Research

Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells

(2019) Chandra Kishore et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

(2019) Komal Qureshi-Baig et al.   Autophagy

Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells

(2019) Farnaz Hajizadeh et al.   LIFE SCIENCES

Selective Regulation of B-Raf Dependent K-Ras/Mitogen-Activated Protein by Natural Occurring Multi-kinase Inhibitors in Cancer Cells

(2019) Ahmed I. Abd El Maksoud et al.   Frontiers in Oncology

The biology and role of CD44 in cancer progression: therapeutic implications

(2018) Chen Chen et al.   Journal of Hematology & Oncology

Inhibition of Siah2 Ubiquitin Ligase by Vitamin K3 Attenuates Chronic Myeloid Leukemia Chemo-Resistance in Hypoxic Microenvironment

(2018) Jixian Huang et al.   MEDICAL SCIENCE MONITOR

Therapeutic role of calcium and vitamin K3 in chemically induced hepatocarcinogenesis – new tools for cancer treatment

(2018) Firoz Anwar et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

The hypoxic tumour microenvironment

(2018) Varvara Petrova et al.   Oncogenesis

Role of HIF-1 in Cancer Progression: Novel Insights. A Review

(2018) Aldo Pezzuto et al.   CURRENT MOLECULAR MEDICINE

Chloroquine and hydroxychloroquine inhibit bladder cancer cell growth by targeting basal autophagy and enhancing apoptosis

(2017) Yi-Chia Lin et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Hypoxia inducible factor-1α regulates autophagy via the p27-E2F1 signaling pathway

(2017) Pan Wang et al.   Molecular Medicine Reports

Vitamin K and its analogs: Potential avenues for prostate cancer management

(2017) Subramanyam Dasari et al.   Oncotarget

CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells

(2016) Soo Young Lee et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Chloroquine Exerts Anti-metastatic Activities Under Hypoxic Conditions in Cholangiocarcinoma Cells

(2015) Suyanee Thongchot et al.   Asian Pacific Journal of Cancer Prevention

SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status

(2015) M Gordian Adam et al.   CELL CYCLE

Role of autophagy in the maintenance and function of cancer stem cells

(2015) Ilio Vitale et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Novel therapy for locally advanced triple-negative breast cancer

(2015) ATSUKO YAMADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting Hypoxia-Inducible Factor 1 to Stimulate Tissue Vascularization

(2015) Gregg L. Semenza   JOURNAL OF INVESTIGATIVE MEDICINE

Cancer stem cells in progression of colorectal cancer

(2015) Yujuan Zhou et al.   Oncotarget

Menadione (Vitamin K3) Induces Apoptosis of Human Oral Cancer Cells and Reduces their Metastatic Potential by Modulating the Expression of Epithelial to Mesenchymal Transition Markers and Inhibiting Migration

(2014) Shruthy Suresh et al.   Asian Pacific Journal of Cancer Prevention

Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice

(2014) Vandana Megaraj et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Hydroxychloroquine Improves Endothelial Dysfunction and Protects Kidney in a Mouse Model of Systemic Lupus Erythematosus

(2014) Manuel Gómez-Guzmán et al.   HYPERTENSION

Aged garlic extract inhibits 1,2-dimethylhydrazine-induced colon tumor development by suppressing cell proliferation

(2014) HIROSHI JIKIHARA et al.   ONCOLOGY REPORTS

Hydroxychloroquine facilitates autophagosome formation but not degradation to suppress the proliferation of cervical cancer SiHa cells

(2014) QINGSONG LIU et al.   Oncology Letters

Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells

(2013) Shaobin Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

(2013) Haitao Zhu et al.   Cancer Cell International

Siah: A Promising Anticancer Target

(2013) C. S. F. Wong et al.   CANCER RESEARCH

Plumbagin, a Vitamin K3 Analogue, abrogates Lipopolysaccharide-Induced Oxidative Stress, Inflammation and Endotoxic Shock via NF-κB Suppression

(2013) Rahul Checker et al.   INFLAMMATION

Hypoxia-Induced Reactive Oxygen Species Cause Chromosomal Abnormalities in Endothelial Cells in the Tumor Microenvironment

(2013) Miyako Kondoh et al.   PLoS One

CD133 Affects the Invasive Ability of HCT116 Cells by Regulating TIMP-2

(2012) Min Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of hypoxia and HIFs on cancer metabolism

(2012) Vera Mucaj et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

(2011) Bruno Bernardes de Jesus et al.   AGING CELL

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis

(2011) M N Khan et al.   BRITISH JOURNAL OF CANCER

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Antitumor and antimetastatic activities of chloroquine diphosphate in a murine model of breast cancer

(2010) Pei-Du Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors

(2010) Jianfei Qi et al.   CANCER CELL

Morphological and Molecular Alterations in 1,2 Dimethylhydrazine and Azoxymethane Induced Colon Carcinogenesis in Rats

(2010) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells

(2009) Rayhana Rahim et al.   ANTI-CANCER DRUGS

The Ubiquitin Ligase Siah2 and the Hypoxia Response

(2009) K. Nakayama et al.   MOLECULAR CANCER RESEARCH

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

(2009) Meera Shah et al.   Pigment Cell & Melanoma Research

Mouse models for the study of colon carcinogenesis

(2008) D. W. Rosenberg et al.   CARCINOGENESIS